Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells [PDF]
International Journal of Nanomedicine, 2015 Kunwoo Lee,1,2 Pengzhi Yu,3 Nithya Lingampalli,1 Hyun Jin Kim,1 Richard Tang,1 Niren Murthy1,2 1Department of Bioengineering, University of California, Berkeley, CA, USA; 2UC Berkeley and UCSF Joint Graduate Program in Bioengineering, Berkeley/San ...
Lee K +5 more
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Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens [PDF]
Nature CommunicationsCardiac fibrosis is mediated by the persistent activity of myofibroblasts, which differentiates from resident cardiac fibroblasts in response to tissue damage and stress signals.
Laura Pilar Aguado-Alvaro +25 more
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Cell autonomous TLR4 signaling modulates TGF-β induced activation of human cardiac fibroblasts [PDF]
HeliyonFibrosis is one of the major outcomes following injury in the heart. Immune response in the injury niche modulates fibrosis, yet little is known about how cell-autonomous immune signaling in adult cardiac fibroblasts regulates fibrosis.
Gayathri Vijayakumar +6 more
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Unique patterns of cardiogenic and fibrotic gene expression in rat cardiac fibroblasts [PDF]
Veterinary World, 2020 Background and Aim: Cardiac fibroblasts are important for both normal and pathological states of the heart, but the knowledge in cell physiology and genomics is still poorly understood.
Kittipong Tachampa, Tuempong Wongtawan
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Induction of Senescence by Loss of Gata4 in Cardiac Fibroblasts
Cells, 2023 Cardiac fibroblasts are a major source of cardiac fibrosis during heart repair processes in various heart diseases. Although it has been shown that cardiac fibroblasts become senescent in response to heart injury, it is unknown how the senescence of ...
Zhentao Zhang +6 more
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Isolation and Culture of Primary Fibroblasts from Neonatal Murine Hearts to Study Cardiac Fibrosis
Bio-Protocol, 2023 Cardiac fibroblasts are one of the major constituents of a healthy heart. Cultured cardiac fibroblasts are a crucial resource for conducting studies on cardiac fibrosis. The existing methods for culturing cardiac fibroblasts involve complicated steps and
Shweta Kumar +4 more
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Frontiers in Molecular Neuroscience, 2022 The peripheral nervous system has remarkable regenerative capabilities. Schwann cells and fibroblasts are known to play crucial roles in these processes.
Yan Li +7 more
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REV-ERB is essential in cardiac fibroblasts homeostasis
Frontiers in Pharmacology, 2022 REV-ERB agonists have shown antifibrotic effects in the heart and other organs. The function of REV-ERB in the cardiac fibroblasts remains unstudied. Here, we characterize the functional difference of REV-ERB in mouse embryonic fibroblasts and cardiac ...
Xiaokang Luo +11 more
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Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons
Neural Regeneration Research, 2022 Peripheral nerve fibroblasts play a critical role in nerve development and regeneration. Our previous study found that peripheral nerve fibroblasts have different sensory and motor phenotypes.
Qian-Ru He +6 more
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Cells, 2021 In response to stretch, cardiac tissue produces natriuretic peptides, which have been suggested to have beneficial effects in heart failure patients.
Meike C. Ploeg +5 more
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