Results 11 to 20 of about 182,384 (307)

Cardiac Fibroblasts: Helping or Hurting. [PDF]

Genes (Basel)
Cardiac fibroblasts (CFs) are the essential cell type for heart morphogenesis and homeostasis. In addition to maintaining the structural integrity of the heart tissue, muscle fibroblasts are involved in complex signaling cascades that regulate cardiomyocyte proliferation, migration, and maturation. While CFs serve as the primary source of extracellular
Shameem M, Olson SL, Marron Fernandez de Velasco E, Kumar A, Singh BN.   +4 more
europepmc   +3 more sources

Cardiac Fibroblasts and Myocardial Regeneration [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
The billions of cardiomyocytes lost to acute myocardial infarction (MI) cannot be replaced by the limited regenerative capacity of adult mammalian hearts, and despite decades of research, there are still no clinically effective therapies for remuscularizing and restoring damaged myocardial tissue.
Wangping Chen, Wangping Chen, Weihua Bian, Yang Zhou, Jianyi Zhang   +4 more
openaire   +3 more sources

Cardiac Fibroblast [PDF]

Circulation Research, 2009
The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes, endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated that there are undulating changes in cardiac cell populations during embryonic development, through neonatal development and into the adult.
Colby A, Souders, Stephanie L K, Bowers, Troy A, Baudino   +2 more
openaire   +2 more sources

Cardiac Fibrosis and Fibroblasts [PDF]

Cells, 2021
Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen. Myofibroblasts are major players in the production of collagen, and are differentiated primarily from resident fibroblasts. Collagen can compensate for the dead cells produced by injury.
openaire   +3 more sources

Conservation of miR combo based direct cardiac reprogramming

Biochemistry and Biophysics Reports, 2022
There is considerable interest in regenerating the injured heart by reprogramming resident fibroblasts into new functional cardiomyocytes. Cardiac reprogramming has been achieved via transcription factors or miRNAs.
Syeda Samara Baksh, Conrad P. Hodgkinson
doaj   +1 more source

Origins of Cardiac Fibroblasts [PDF]

Circulation Research, 2010
Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms.
Zeisberg, Elisabeth M., Kalluri, Raghu
openaire   +3 more sources

Origins of cardiac fibroblasts [PDF]

Journal of Molecular and Cellular Cardiology, 2016
Cardiac fibroblasts produce the extracellular matrix (ECM) scaffold within which the various cellular components of the heart are organized. As well as providing structural support, it is becoming evident that the quality and quantity of ECM is a key factor for determining cardiac cell behavior during development and in pathological contexts such as ...
Moore-Morris T., Cattaneo P., Puceat M., Evans S. M.   +3 more
openaire   +3 more sources

Direct Cardiac Reprogramming: Progress and Promise. [PDF]

, 2018
The human adult heart lacks a robust endogenous repair mechanism to fully restore cardiac function after insult; thus, the ability to regenerate and repair the injured myocardium remains a top priority in treating heart failure.
Ardehali, Reza, Engel, James L
core   +7 more sources

Cardiac fibroblasts: answering the call. [PDF]

Am J Physiol Heart Circ Physiol
Cardiac fibroblasts play a pivotal role in maintaining heart homeostasis by depositing extracellular matrix (ECM) to provide structural support for the myocardium, vasculature, and neuronal network and by contributing to essential physiological processes.
Kleinbongard P, Senyo SE, Lindsey ML, Garvin AM, Simpson JA, de Castro Braz LE.   +5 more
europepmc   +3 more sources

Cardiac fibroblasts [PDF]

Herzschrittmachertherapie + Elektrophysiologie, 2018
Fibrotic areas in cardiac muscle-be it in ventricular or atrial tissue-are considered as obstacles for conduction of the excitatory wave and can therefore facilitate re-entry, which may contribute to the sustenance of cardiac arrhythmias. Persistence of one of the most frequent arrhythmias, atrial fibrillation (AF), is accompanied by enhanced atrial ...
Klesen, Alexander, Jakob, Dorothee Ruth, Emig, Ramona, Kohl, Peter, Ravens, Ursula, Peyronnet, Remi   +5 more
openaire   +3 more sources