Results 21 to 30 of about 182,384 (307)

Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts. [PDF]

PLoS ONE, 2013
Differentiation of cardiac fibroblasts into myofibroblasts is a critical event in the progression of cardiac fibrosis that leads to pathological cardiac remodeling.
Jian Bai, Na Zhang, Ying Hua, Bingjian Wang, Lin Ling, Albert Ferro, Biao Xu   +6 more
doaj   +1 more source

Inhibition of Wdr5 Attenuates Ang-II-Induced Fibroblast-to-Myofibroblast Transition in Cardiac Fibrosis by Regulating Mdm2/P53/P21 Pathway

Biomolecules, 2022
Cardiac fibrosis is an important pathological process in many diseases. Wdr5 catalyzes the trimethylation of lysine K4 on histone H3. The effects of Wdr5 on the cardiac fibrosis phenotype and the activation or transformation of cardiac fibroblasts were ...
Jiali Yuan, Hong Peng, Binfeng Mo, Chengye Yin, Guojian Fang, Yingze Li, Yuepeng Wang, Renhua Chen, Qunshan Wang   +8 more
doaj   +1 more source

Emerging role of transient receptor potential (TRP) ion channels in cardiac fibroblast pathophysiology

Frontiers in Physiology, 2022
Cardiac fibroblasts make up a major proportion of non-excitable cells in the heart and contribute to the cardiac structural integrity and maintenance of the extracellular matrix.
Asfree Gwanyanya, Kanigula Mubagwa, Kanigula Mubagwa   +2 more
doaj   +1 more source

The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]

, 2017
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena, Dal Sasso, Eleonora, Forte, Maurizio, Frati, Giacomo, Gerosa, Gino, Iop, Laura, Palmerio, Silvia, Peruzzi, Mariangela, Schirone, Leonardo, Sciarretta, Sebastiano   +9 more
core   +4 more sources

Toll-like receptor 9 mediated responses in cardiac fibroblasts. [PDF]

PLoS ONE, 2014
Altered cardiac Toll-like receptor 9 (TLR9) signaling is important in several experimental cardiovascular disorders. These studies have predominantly focused on cardiac myocytes or the heart as a whole.
Ingrid Kristine Ohm, Katrine Alfsnes, Maria Belland Olsen, Trine Ranheim, Øystein Sandanger, Tuva Børresdatter Dahl, Pål Aukrust, Alexandra Vanessa Finsen, Arne Yndestad, Leif Erik Vinge   +9 more
doaj   +1 more source

Novel Techniques Targeting Fibroblasts after Ischemic Heart Injury

Cells, 2022
The great plasticity of cardiac fibroblasts allows them to respond quickly to myocardial injury and to contribute to the subsequent cardiac remodeling.
Sirin N. Cakir, Kaitlin M. Whitehead, Hanifah K. L. Hendricks, Lisandra E. de Castro Brás   +3 more
doaj   +1 more source

MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart [PDF]

, 2012
MicroRNAs (miRs) are small non- coding RNA molecules controlling a plethora of biological processes such as development, cellular survival and senescence.
Bauersachs, Johann, Fiedler, Jan, Galuppo, Paolo, Holzmann, Angelika, Jazbutyte, Virginija, Just, Annette, Kneitz, Susanne, Thum, Thomas   +7 more
core   +1 more source

Isolation and Primary Culture of Adult Mouse Cardiac Fibroblasts

Bio-Protocol, 2016
Fibroblasts are often used as a feeder layer for progenitor or stem cells in co-culture systems. In the heart fibroblasts are important for cardiac development, homeostasis, and remodelling.
Maria Zafeiriou, Claudia Noack, Laura Zelarayan   +2 more
doaj   +1 more source

Loss of Function in Dopamine D3 Receptor Attenuates Left Ventricular Cardiac Fibroblast Migration and Proliferation in vitro

Frontiers in Cardiovascular Medicine, 2021
Evidence suggests the existence of an intracardiac dopaminergic system that plays a pivotal role in regulating cardiac function and fibrosis through G-protein coupled receptors, particularly mediated by dopamine receptor 3 (D3R).
Andrew Kisling, Shannon Byrne, Rohan U. Parekh, Deepthy Melit-Thomas, Lisandra E. de Castro Brás, Lisandra E. de Castro Brás, Robert M. Lust, Stefan Clemens, Srinivas Sriramula, Laxmansa C. Katwa   +9 more
doaj   +1 more source

Heartbreak hotel: a convergence in cardiac regeneration [PDF]

, 2016
In February 2016, the Company of Biologists hosted an intimate gathering of leading international researchers at the forefront of experimental cardiovascular regeneration, with its emphasis on ‘Transdifferentiation and Tissue Plasticity in Cardiovascular
Schneider, MD
core   +1 more source