Results 11 to 20 of about 31,824 (209)

Cardiotoxicity of Plants in Iran: a Review [PDF]

The Iranian Journal of Veterinary Science and Technology, 2018
In this review an attempt has been made to review the cardiotoxic effects of poisonous plants which are found in Iran. Among various plant species growing in different regions of Iran, a large number of plants contain chemical compounds which are ...
Mohammad R. Aslani
doaj   +2 more sources

Cardiac Glycosides and Cardiomyopathy [PDF]

Hypertension, 2006
Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering’s seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body ...
MANUNTA , PAOLO, FERRANDI M.
openaire   +3 more sources

Live cell screening identifies glycosides as enhancers of cardiomyocyte cell cycle activity

Frontiers in Cardiovascular Medicine, 2022
Promoting cardiomyocyte proliferation is a promising strategy to regenerate the heart. Yet, so far, it is poorly understood how cardiomyocyte proliferation is regulated, and no factor identified to promote mammalian cardiomyocyte proliferation has been ...
Ajit Magadum, Ajit Magadum, Ajit Magadum, Harsha V. Renikunta, Harsha V. Renikunta, Neha Singh, Conchi Estaras, Raj Kishore, Raj Kishore, Felix B. Engel, Felix B. Engel, Felix B. Engel   +11 more
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The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction. [PDF]

PLoS ONE, 2017
Cardiac glycosides such as digoxin are Na+/K+-ATPase inhibitors that are widely used for the treatment of chronic heart failure and cardiac arrhythmias; however, recent epidemiological studies have suggested a relationship between digoxin treatment and ...
Motoi Kobayashi, Fumitake Usui-Kawanishi, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Nathan Mise, Fujio Kayama, Tadashi Kasahara, Naoyuki Hasebe, Masafumi Takahashi   +9 more
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Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis. [PDF]

PLoS ONE, 2009
BACKGROUND:Cardiac glycosides are Na(+)/K(+)-pump inhibitors widely used to treat heart failure. They are also highly cytotoxic, and studies have suggested specific anti-tumor activity leading to current clinical trials in cancer patients.
Andrea Perne, Markus K Muellner, Magdalena Steinrueck, Nils Craig-Mueller, Julia Mayerhofer, Ilse Schwarzinger, Mathew Sloane, Iris Z Uras, Gregor Hoermann, Sebastian M B Nijman, Matthias Mayerhofer   +10 more
doaj   +1 more source

Identification of key genes involved in secondary metabolite biosynthesis in Digitalis purpurea

PLoS ONE, 2023
The medicinal plant Digitalis purpurea produces cardiac glycosides that are useful in the pharmaceutical industry. These bioactive compounds are in high demand due to ethnobotany’s application to therapeutic procedures.
Fatemeh Amiri, Ali Moghadam, Ahmad Tahmasebi, Ali Niazi   +3 more
doaj   +2 more sources

Pharmacological aspects of acute treatment glycoside intoxication

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021
Despite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases.
M. I. Sperling, E. G. Kruchinin, A. S. Gogolevsky   +2 more
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Cardiac glycosides and breast cancer risk: A systematic review and meta-analysis of observational studies [PDF]

, 2017
Cardiac glycosides are phytoestrogens and have been linked to the risk of estrogen sensitive cancers such as uterus cancer. However, the association between use of cardiac glycosides and risk of breast cancer remains unclear.
Ahern, Ahern, Aromaa, Beral, Biggar, Biggar, Biggar, Braunstein, Collaborative Group on Hormonal Factors in Breast Cancer, Couraud, Cuzick, Danielson, DerSimonian, Dickey, Friedman, Hartz, Haux, Higgins, International Agency for Research on Cancer, Joint Formulary Committee, Kirkwood, Rifka, Rifka, Rossouw, Schneeweiss, Stenkvist, Stenkvist   +26 more
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The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]

, 2011
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra, Cahill, Catherine M., Castelvetri, Ippolita Cantuti, Greig, Nigel H., Huang, Xudong, Lahiri, Debomoy K., Maccecchini, Maria L., Mikkilineni, Sohan, Rogers, Jack T., Smith, Deborah H.   +9 more
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Estimation of Tannin, Saponin, Oxalate, Cyanogenic and Cardiac Glycosides in Garsinia Kola

Journal of Applied Sciences and Environmental Management, 2004
The presence of some secondary plant metabolites — tannin, saponin, oxalate, cyanogenic and cardiac glycosides were done in Garsinia Cola. The tannin, saponin and oxalate content were 0.69 ± 0.01, 15.79 ± 0.28 and 1.707 ± 0.13mg/100g of dry sample ...
C.C. MONAGO, V. AKHIDUE
doaj   +1 more source