Results 1 to 10 of about 4,774 (217)

Malassezia globosa lipidome: The dynamics of uptake and secreted lipids [PDF]

Virulence
Malassezia globosa plays a crucial role as part of the human skin’s mycobiome. However, this yeast has been detected in other niches, such as the gut.
Catherine Eliana Cabrera Díaz, Mónica P. Cala, Elizabeth Jiménez-Díaz, Adriana Marcela Celis Ramírez   +3 more
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The lipidome of the kidney tubules of ob/ob mice is affected at the infralesional level [PDF]

Cell Death Discovery
Whether changes in tubular lipidomic composition precede the onset of observable kidney damage in obesity is unknown. We manually isolated the proximal convoluted tubule (PCT), the cortical thick ascending limb of Henle’s loop (cTAL) and the cortical ...
Lydie Cheval, Julio L. Sampaio, Virginie Poindessous, Gilles Crambert, Nicolas Pallet   +4 more
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Cardiolipin acyl chain composition tailors the conformation of mammalian ATP synthase dimers [PDF]

Communications Chemistry
The interplay between ATP synthase dimers and the four-tailed lipid cardiolipin (CL) shapes mitochondrial cristae structure and function. In the mitochondrial disorder Barth syndrome (BTHS), cristae membranes accumulate a less unsaturated, three-tailed ...
M. Makowski, V. G. Almendro-Vedia, I. López-Montero   +2 more
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Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study [PDF]

Biomolecules
Endometriosis is a prevalent chronic inflammatory disease characterized by a considerable delay between initial symptoms and diagnosis through surgery.
Natalia Starodubtseva, Vitaliy Chagovets, Alisa Tokareva, Madina Dumanovskaya, Eugenii Kukaev, Anastasia Novoselova, Vladimir Frankevich, Stanislav V. Pavlovich, Gennady Sukhikh   +8 more
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Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation

Research, 2022
Precise metabolic rewiring during heart organogenesis underlies normal cardiac development. Herein, we utilized high-coverage, quantitative lipidomic approaches to construct lipidomic atlases of whole hearts (861 lipids; 31 classes) and mitochondria (587
Huan Miao, Bowen Li, Zehua Wang, Jinming Mu, Yanlin Tian, Binhua Jiang, Shaohua Zhang, Xia Gong, Guanghou Shui, Sin Man Lam   +9 more
doaj   +1 more source

Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant

Redox Biology, 2023
The aim of this study was to examine, in biochemical detail, the functional role of the Arg152 residue in the selenoprotein Glutathione Peroxidase 4 (GPX4), whose mutation to His is involved in Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD).
Antonella Roveri, Flavio Di Giacinto, Monica Rossetto, Giorgio Cozza, Qing Cheng, Giovanni Miotto, Lucio Zennaro, Maria Luisa Di Paolo, Elias S.J. Arnér, Marco De Spirito, Matilde Maiorino, Fulvio Ursini   +11 more
doaj   +1 more source

Role of cardiolipins, mitochondria, and autophagy in the differentiation process activated by all-trans retinoic acid in acute promyelocytic leukemia

Cell Death and Disease, 2022
The role played by lipids in the process of granulocytic differentiation activated by all-trans retinoic acid (ATRA) in Acute-Promyelocytic-Leukemia (APL) blasts is unknown.
Maurizio Gianni’, Laura Goracci, Anna Schlaefli, Alessandra Di Veroli, Mami Kurosaki, Luca Guarrera, Marco Bolis, Marika Foglia, Monica Lupi, Mario P. Tschan, Gabriele Cruciani, Mineko Terao, Enrico Garattini   +12 more
doaj   +1 more source

Different Lipid Signature in Fibroblasts of Long-Chain Fatty Acid Oxidation Disorders

Cells, 2021
Long-chain fatty acid oxidation disorders (lc-FAOD) are a group of diseases affecting the degradation of long-chain fatty acids. In order to investigate the disease specific alterations of the cellular lipidome, we performed undirected lipidomics in ...
Khaled I. Alatibi, Judith Hagenbuchner, Zeinab Wehbe, Daniela Karall, Michael J. Ausserlechner, Jerry Vockley, Ute Spiekerkoetter, Sarah C. Grünert, Sara Tucci   +8 more
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Mitochondrial Lipid Signaling and Adaptive Thermogenesis

Metabolites, 2021
Thermogenesis is an energy demanding process by which endotherms produce heat to maintain their body temperature in response to cold exposure. Mitochondria in the brown and beige adipocytes play a key role in thermogenesis, as the site for uncoupling ...
Helaina Von Bank, Mae Hurtado-Thiele, Nanami Oshimura, Judith Simcox   +3 more
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Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Biology of Sex Differences, 2021
Highlights AMPK is a metabolic sensor of cellular energy which regulates energy homeostasis. We generated a cardiac-specific inducible deletion of Ampkα2 and demonstrated that this deletion induces mild cardiac dysfunction in male only.
Lucile Grimbert, Maria-Nieves Sanz, Mélanie Gressette, Catherine Rucker-Martin, Marta Novotova, Audrey Solgadi, Ahmed Karoui, Susana Gomez, Kaveen Bedouet, Eric Jacquet, Christophe Lemaire, Vladimir Veksler, Mathias Mericskay, Renée Ventura-Clapier, Jérôme Piquereau, Anne Garnier   +15 more
doaj   +1 more source