Results 1 to 10 of about 8,226 (286)
The lipidome of the kidney tubules of ob/ob mice is affected at the infralesional level [PDF]
Cell Death DiscoveryWhether changes in tubular lipidomic composition precede the onset of observable kidney damage in obesity is unknown. We manually isolated the proximal convoluted tubule (PCT), the cortical thick ascending limb of Henle’s loop (cTAL) and the cortical ...
Lydie Cheval +4 more
doaj +2 more sources
Cardiolipin acyl chain composition tailors the conformation of mammalian ATP synthase dimers [PDF]
Communications ChemistryThe interplay between ATP synthase dimers and the four-tailed lipid cardiolipin (CL) shapes mitochondrial cristae structure and function. In the mitochondrial disorder Barth syndrome (BTHS), cristae membranes accumulate a less unsaturated, three-tailed ...
M. Makowski +2 more
doaj +2 more sources
Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study [PDF]
BiomoleculesEndometriosis is a prevalent chronic inflammatory disease characterized by a considerable delay between initial symptoms and diagnosis through surgery.
Natalia Starodubtseva +8 more
doaj +2 more sources
Ionization constants pKa of cardiolipin. [PDF]
PLoS ONE, 2013 Cardiolipin is a phospholipid found in the inner mitochondrial membrane and in bacteria, and it is associated with many physiological functions. Cardiolipin has a dimeric structure consisting of two phosphatidyl residues connected by a glycerol bridge ...
Gerd Olofsson, Emma Sparr
doaj +4 more sources
Influence of diet-induced obesity and voluntary exercise training on cardiac lipids and mitochondrial function in mice [PDF]
Journal of Sport and Health ScienceBackground: Obesity is a risk factor for developing cardiometabolic disease. Exercise training is pivotal in the treatment of obesity and is associated with reduced cardiovascular mortality.
Nimna Perera +13 more
doaj +2 more sources
Research, 2022 Precise metabolic rewiring during heart organogenesis underlies normal cardiac development. Herein, we utilized high-coverage, quantitative lipidomic approaches to construct lipidomic atlases of whole hearts (861 lipids; 31 classes) and mitochondria (587
Huan Miao +9 more
doaj +1 more source
Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant
Redox Biology, 2023 The aim of this study was to examine, in biochemical detail, the functional role of the Arg152 residue in the selenoprotein Glutathione Peroxidase 4 (GPX4), whose mutation to His is involved in Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD).
Antonella Roveri +11 more
doaj +1 more source
Cell Death and Disease, 2022 The role played by lipids in the process of granulocytic differentiation activated by all-trans retinoic acid (ATRA) in Acute-Promyelocytic-Leukemia (APL) blasts is unknown.
Maurizio Gianni’ +12 more
doaj +1 more source
Different Lipid Signature in Fibroblasts of Long-Chain Fatty Acid Oxidation Disorders
Cells, 2021 Long-chain fatty acid oxidation disorders (lc-FAOD) are a group of diseases affecting the degradation of long-chain fatty acids. In order to investigate the disease specific alterations of the cellular lipidome, we performed undirected lipidomics in ...
Khaled I. Alatibi +8 more
doaj +1 more source
Mitochondrial Lipid Signaling and Adaptive Thermogenesis
Metabolites, 2021 Thermogenesis is an energy demanding process by which endotherms produce heat to maintain their body temperature in response to cold exposure. Mitochondria in the brown and beige adipocytes play a key role in thermogenesis, as the site for uncoupling ...
Helaina Von Bank +3 more
doaj +1 more source