The lipidome of the kidney tubules of ob/ob mice is affected at the infralesional level [PDF]
Cell Death DiscoveryWhether changes in tubular lipidomic composition precede the onset of observable kidney damage in obesity is unknown. We manually isolated the proximal convoluted tubule (PCT), the cortical thick ascending limb of Henle’s loop (cTAL) and the cortical ...
Lydie Cheval +4 more
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Cardiolipin acyl chain composition tailors the conformation of mammalian ATP synthase dimers [PDF]
Communications ChemistryThe interplay between ATP synthase dimers and the four-tailed lipid cardiolipin (CL) shapes mitochondrial cristae structure and function. In the mitochondrial disorder Barth syndrome (BTHS), cristae membranes accumulate a less unsaturated, three-tailed ...
M. Makowski +2 more
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Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study [PDF]
BiomoleculesEndometriosis is a prevalent chronic inflammatory disease characterized by a considerable delay between initial symptoms and diagnosis through surgery.
Natalia Starodubtseva +8 more
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An optimized plasmalogen modulating dietary supplement provides greater protection in a male than female mouse model of dilated cardiomyopathy [PDF]
Journal of Molecular and Cellular Cardiology PlusWe previously reported that plasmalogens, a class of phospholipids, were decreased in a setting of dilated cardiomyopathy (DCM). Plasmalogen levels can be modulated via a dietary supplement called alkylglycerols (AG) which has demonstrated benefits in ...
Teleah G. Belkin +17 more
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Mono- to tetra-alkyl ether cardiolipins in a mesophilic, sulfate-reducing bacterium identified by UHPLC-HRMSn: a novel class of membrane lipids [PDF]
Frontiers in MicrobiologyThe composition of membrane lipids varies in a number of ways as adjustment to growth conditions. Variations in head group composition and carbon skeleton and degree of unsaturation of glycerol-bound acyl or alkyl chains results in a high structural ...
Ellen C. Hopmans +6 more
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Research, 2022 Precise metabolic rewiring during heart organogenesis underlies normal cardiac development. Herein, we utilized high-coverage, quantitative lipidomic approaches to construct lipidomic atlases of whole hearts (861 lipids; 31 classes) and mitochondria (587
Huan Miao +9 more
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Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant
Redox Biology, 2023 The aim of this study was to examine, in biochemical detail, the functional role of the Arg152 residue in the selenoprotein Glutathione Peroxidase 4 (GPX4), whose mutation to His is involved in Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD).
Antonella Roveri +11 more
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Cell Death and Disease, 2022 The role played by lipids in the process of granulocytic differentiation activated by all-trans retinoic acid (ATRA) in Acute-Promyelocytic-Leukemia (APL) blasts is unknown.
Maurizio Gianni’ +12 more
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Different Lipid Signature in Fibroblasts of Long-Chain Fatty Acid Oxidation Disorders
Cells, 2021 Long-chain fatty acid oxidation disorders (lc-FAOD) are a group of diseases affecting the degradation of long-chain fatty acids. In order to investigate the disease specific alterations of the cellular lipidome, we performed undirected lipidomics in ...
Khaled I. Alatibi +8 more
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Mitochondrial Lipid Signaling and Adaptive Thermogenesis
Metabolites, 2021 Thermogenesis is an energy demanding process by which endotherms produce heat to maintain their body temperature in response to cold exposure. Mitochondria in the brown and beige adipocytes play a key role in thermogenesis, as the site for uncoupling ...
Helaina Von Bank +3 more
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