Results 81 to 90 of about 31,146 (236)

PKCε and cardioprotection : an exploration of putative mechanisms [PDF]

, 2006
Includes bibliographical references.Recent studies have investigated the underlying regulatory mechanisms that may explain the cardioprotective role of PKCε.
McCarthy, Joy
core   +1 more source

Trimetazidine and Cardioprotection

Angiology, 2014
Trimetazidine (TMZ) is a metabolic agent used in cardiology for more than 40 years. Several studies assessed the cardioprotective effects of TMZ in patients with chronic coronary heart disease (CHD) as well as in patients with heart failure (HF). In light of the inclusion of TMZ in the current guidelines on the management of stable CHD, we reviewed the
Tsioufis, K., Andrikopoulos, G., Manolis, A.   +2 more
openaire   +3 more sources

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

Perioperative cardioprotection as a measure to reduce the risk of posthospital cardiovascular complications (cohort study)

Вестник анестезиологии и реаниматологии
The objective was to study the incidence of the late cardiovascular complications depending on the use of perioperative cardioprotection in patients with high cardiac risk.Materials and methods.
D. A. Sokolov, I. A. Kozlov
doaj   +1 more source

mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection. [PDF]

PLoS ONE, 2014
Hydrogen sulfide (H2S) is known to have cardiac protective effects through Akt activation. Akt acts as a 'central sensor' for myocyte survival or death; its activity is regulated by multiple kinases including PI3K, mTORC2, PDK1 and phosphatases including
Yue Zhou, Daying Wang, Xiufang Gao, Karsheng Lew, Arthur Mark Richards, Peipei Wang   +5 more
doaj   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

Advances in cardioprotective strategies: Bridging traditional pharmacotherapy and regenerative medicine [PDF]

Scripta Medica
Cardiovascular diseases (CVDs) remain the leading global cause of death and disability, underscoring the need for improved therapies. Key emerging strategies include pharmacological cardioprotection, cell-based therapies and the use of exosomes as ...
Hladkykh Fedir V., Matvieienko Mariia M., Liadova Tetiana I, Karafulidi Olha V., Komorovsky Roman R.   +4 more
doaj   +1 more source

Redox balance and cardioprotection [PDF]

Basic Research in Cardiology, 2013
Coronary artery disease is a major cause of morbidity and mortality in the Western countries. Acute myocardial infarction is a serious and often lethal consequence of coronary artery disease, resulting in contractile dysfunction and cell death. It is well known that unbalanced and high steady state levels of reactive oxygen and nitrogen species (ROS ...
Francesca, Tullio, Carmelina, Angotti, Maria-Giulia, Perrelli, Claudia, Penna, Pasquale, Pagliaro   +4 more
openaire   +2 more sources

Vaccarin Improves Myocardial Ischemia–Reperfusion Injury by Attenuating Oxidative Stress and Ferroptosis Through Reducing NOX4‐Modulated JAK2/STAT3 Pathway Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Vaccarin is a naturally occurring flavonoid glycoside with cardioprotective properties; however, its involvement in myocardial ischemia–reperfusion (MI/R) injury remains poorly defined. We herein investigated whether vaccarin protects cardiomyocytes from MI/R‐induced dysfunction in vivo and in vitro and examined the associated molecular ...
Han Yang, Mi Zhou, Feng‐Cai Zhang
wiley   +1 more source

Coffee for Cardioprotection and Longevity [PDF]

Progress in Cardiovascular Diseases, 2018
Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recently, a plethora of studies have been published focusing on health outcomes associated with coffee intake. An inverse association between coffee consumption and all-cause mortality has been seen consistently in large ...
O'Keefe, James H., DiNicolantonio, James J., Lavie, Carl J.   +2 more
openaire   +5 more sources