Results 101 to 110 of about 31,146 (236)

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder, Anna‐Maria Pfützenreuter, Lea Maria Funke, Maria Johanna Baier, Daniel Tarnowski, Laura Stengel, Lars Siegfried Maier, Can Martin Sag   +7 more
wiley   +1 more source

Perioperative Cardioprotection: Clinical Implications

, 2020
Perioperative cardioprotection aims to minimize the consequences of myocardial ischemia-reperfusion injury. In isolated tissue and animal experiments, several treatments have been identified providing cardioprotection.
Hollmann, Markus W., Huhn, Ragnar, Preckel, Benedikt, Torregroza, Carolin, Roth, Sebastian   +4 more
core   +1 more source

Heart failure medication to prevent cancer therapy–related cardiac dysfunction: A narrative review

British Journal of Pharmacology, EarlyView.
Advances in oncological therapies have improved cancer survival but also have increased the clinical incidence of cancer therapy–related cardiac dysfunction (CTRCD), a spectrum of conditions ranging from subclinical biomarker or strain abnormalities to progressive heart failure and cardiogenic shock.
Fabian Voß, Paul Goerke, Malte Kelm, Amin Polzin   +3 more
wiley   +1 more source

Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations [PDF]

, 2010
Ischemic heart disease (IHD) is the leading cause of death worldwide. Novel cardioprotective strategies are therefore required to improve clinical outcomes in patients with IHD.
Bøtker, Hans Erik, Kitakaze, Masafumi, Walker, Malcolm, Michel Ovize, Gail Walkinshaw, Hausenloy, Derek J., Gerd Heusch, Mentzer, Robert, Shannon, Richard, Heusch, Gerd, Davidson, Sean M., Gary Baxter, Richard Shannon, Robert Bell, Rainer Schulz, Ovize, Michel, Mihaela M. Mocanu, James Downey, Walkinshaw, Gail, Derek J. Hausenloy, Malcolm Walker, Yellon, Derek M., Bell, Robert, Schulz, Rainer, Mocanu, Mihaela M., Derek M. Yellon, Sean M. Davidson, Masafumi Kitakaze, Downey, James, Sandrine Lecour, Hans Erik Bøtker, Lecour, Sandrine, Robert Mentzer, Baxter, Gary Francis   +33 more
core   +1 more source

Cirbp suppression compromises DHODH-mediated ferroptosis defense and attenuates hypothermic cardioprotection in an aged donor transplantation model

The Journal of Clinical Investigation
Hypothermia is commonly used to protect donor hearts during transplantation. However, patients transplanted with aged donor hearts still have severe myocardial injury and decreased survival rates, but the underlying mechanism remains unknown.
Yifan Zhu, Chenyu Jiang, Jian He, Chen He, Xingliang Zhou, Xu Huang, Yi Shen, Liwei Wu, Yongnan Li, Bei Feng, Yi Yan, Jun Li, Hao Zhang, Yiwei Liu   +13 more
doaj   +1 more source

Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights

British Journal of Pharmacology, EarlyView.
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra, Francesco Niro, Marco Mergiotti, Giovanni Gavatorta, Emilio Hirsch, Alessandra Ghigo   +5 more
wiley   +1 more source

Association of Exercise Preconditioning With Immediate Cardioprotection: A Review. [PDF]

, 2018
Importance: Exercise reduces the risk of cardiovascular events, including through an underrecognized, clinically useful form of acute cardioprotection accessible after a single episode of exercise, which is called cardiovascular preconditioning ...
Redington, A., Keith P. George, Maria T. E. Hopman, Jones, H., Redington, A, George, K.P., Hopman, MTE, Andrew Redington, George, KP, Thijssen, D.H.J., Hopman, M.T.E., Thijssen, DHJ, Jones, H, Dick H. J. Thijssen, Helen Jones   +14 more
core   +1 more source

Restoration of adaptive cardioprotection impaired by metabolic syndrome in rats by the PPARα activation

Acta Biomedica Scientifica
Background. It is known that the protective effect of adaptation and conditioning influence is weakened in animals with metabolic syndrome. Metabolic syndrome may be the basis for the failure of cardioprotection in clinical settings.The aim of the study.
N. V. Naryzhnaya, I. A. Derkachev, B. K. Kurbatov, M. A. Sirotina, M. Kilin, L. N. Maslov   +5 more
doaj   +1 more source

Glucagon-Like Peptide-1

JACC: Basic to Translational Science, 2016
Glucagon-like peptide-1-(7-36) amide (GLP-1) is a human incretin hormone responsible for the release of insulin in response to food. Pre-clinical and human physiological studies have demonstrated cardioprotection from ischemia-reperfusion injury.
Joel P. Giblett, BM, BSc, Sophie J. Clarke, BSc, David P. Dutka, MD, Stephen P. Hoole, MA, DM   +3 more
doaj   +1 more source

Dietary melatonin and its benefits on cardiovascular disease

British Journal of Pharmacology, EarlyView.
Cardiovascular disease remains the leading cause of mortality globally, with a disproportionate burden in low‐ and middle‐income countries. Melatonin, a hormone primarily produced by the pineal gland, exhibits notable antioxidant, anti‐inflammatory and immunomodulatory properties that may confer cardiovascular benefits.
Karabo Tisane, Carmelita Abrahams, Sandrine Lecour   +2 more
wiley   +1 more source