Results 91 to 100 of about 116,755 (297)

Numerical analysis of cartilage surfaces for osteoarthritis diagnosis using field and feature parameters

, 2011
Osteoarthritis (OA) is one of the most common degenerative wear diseases of knee joints worldwide. Within knee joint articular cartilage (AC), collagen structure losing integrity is a major symptom of OA.
Jiang, X., Wang, Jian, Tian, Y., Z. Peng, X. Jiang, J. Wang, Jiang, Xiang, Y. Tian, Wang, J., Peng, Z.   +9 more
core   +1 more source

A new approach to numerical characterisation of wear particle surfaces in three-dimensions for wear study [PDF]

, 2012
In the wear and tear process of synovial joints, wear particles generated and released from articular cartilage within the joints have surface topography and mechanical property which can be used to reveal wear conditions. Three-dimensional (3D) particle
Jiang, X., Wang, Jian, Tian, Y., Tian, Yuan, Jiang, Xiang, Wang, J., Peng, Zhongxiao, Peng, Z.   +7 more
core   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Human Cartilage‐Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration

Stem Cells Translational Medicine, 2016
Articular cartilage is not a physiologically self‐renewing tissue. Injury of cartilage often progresses from the articular surface to the subchondral bone, leading to pathogenesis of tissue degenerative diseases, such as osteoarthritis.
Yangzi Jiang, Youzhi Cai, Wei Zhang, Zi Yin, Changchang Hu, Tong Tong, Ping Lu, Shufang Zhang, Dante Neculai, Rocky S. Tuan, Hong Wei Ouyang   +10 more
doaj   +1 more source

A novel method of articular cartilage repair.

, 2007
Articular cartilage repair of post-traumatic articular cartilage defects and well-defined articular cartilage pathology is challenging in clinical practice and has been the focus of investigations for many years.
Reissis, N., Reissis, Nikolaos
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Longitudinal analysis of cartilage T2 relaxation times and joint degeneration in African American and Caucasian American women over an observation period of 6 years - data from the Osteoarthritis Initiative [PDF]

, 2016
Objectives: To investigate the change in cartilage T2 values and structural degeneration in knee joints over 72 months in women of African American (AA) vs Caucasian American (CA) ethnicity.
Solka, M, Yu, A, Solka, M., McCulloch, C. E., Joseph, GB, Kretzschmar, M., Joseph, G. B., Link, TM, McCulloch, CE, Link, T. M., Heilmeier, U, Nevitt, MC, Liu, F, Yu, A., Nevitt, M. C., Heilmeier, U., Liu, F., Kretzschmar, M   +17 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

An in-vitro medium term simulation of hip hemiarthroplasty [PDF]

, 2012
Hemiarthroplasty of the hip is a common procedure to treat fracture of the neck of femur, which commonly affects the elderly. The treatment involves replacing the femoral head with a metallic component, leaving it to articulate against the cartilage of ...
Taylor, Simon David
core