The Effects of Crocin on Bone and Cartilage Diseases. [PDF]
Front Pharmacol, 2021 Vafaei S +3 more
europepmc +1 more source
Age-related changes to lumbosacral spinal cord motoneurons that modulate bladder and bowel functions in male C57BL/6 mice [PDF]
, 2013 Incontinence and sexual dysfunction are often increased in the aged human population. In rats and mice the pattern of micturition and faecal clearance also changes with ageing and is suggestive of bladder and bowel ...
Black, G. +4 more
core
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone
Advanced Science, EarlyView.In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman +15 more
wiley +1 more source
Blockade of ZMIZ1‐GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage
Advanced ScienceSusceptibility to cartilage degeneration increases in an age‐dependent manner and older cartilage exhibits increased catabolic factor expression leading to osteoarthritis (OA). While inhibition of cellular senescence can prevent age‐related diseases, the
Jiho Nam +8 more
doaj +1 more source
Association of organs-crosstalk with the pathogenesis of osteoarthritis: cartilage as a key player
Frontiers in EndocrinologyDegeneration of articular cartilage is the hallmark pathologic change in osteoarthritis (OA). Cartilage not only serves as a shock-absorbing structure for movement but is also regulated by organs other than bone, while chondrocytes secrete cytokines that
Yingda Qin +4 more
doaj +1 more source
Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES
Advanced Science, EarlyView.In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu +5 more
wiley +1 more source
The Markers Of Bone Metabolism And System Inflammation In Patients With Osteoarthritis Depending On Body Mass, The Influence Of Symptomatic Slow Acting Drugs [PDF]
, 2016 Aim. To assess the levels of markers of the bone synthesis and system inflammation in patients with osteoarthritis (OA) in combination with obesity and their dynamic under the influence of basic treatment.Materials and methods.
Cherkasova, A. (Anna) +1 more
core
Hydrogel-Based 3D Bioprinting Technology for Articular Cartilage Regenerative Engineering
GelsArticular cartilage is an avascular tissue with very limited capacity of self-regeneration. Trauma or injury-related defects, inflammation, or aging in articular cartilage can induce progressive degenerative joint diseases such as osteoarthritis.
Hongji Zhang +3 more
doaj +1 more source
Millimeter‐Scale Dual‐Opposing RNA‐Gradient Hydrogel for Interfacial Gene Silencing
Advanced Science, EarlyView.A branched microfluidic platform enables the fabrication of millimeter‐scale hydrogels with dual‐opposing RNA‐gradients for precise spatial control of cell gene expression. This device allows for the generation of multiple constructs at once, offering potential for future engineering of complex tissue interfaces with improved physiological relevance ...
Tyler Hoffman +11 more
wiley +1 more source