Results 61 to 70 of about 200,296 (309)
Current Applications and Future Perspectives of CRISPR-Cas9 for the Treatment of Lung Cancer
Biologics: Targets & Therapy, 2021 Markeshaw Tiruneh G/Medhin,1 Endeshaw Chekol Abebe,2 Tekeba Sisay,3 Nega Berhane,3 Tesfahun Bekele Snr,1 Tadesse Asmamaw Dejenie1 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar ...
Tiruneh G/Medhin M +5 more
doaj
Cas9-mediated IGH-BCL6 translocations (der3) in human B cells.
, 2019 (A) Schematic depicting sgRNA target regions in IGH on human chromosome 14 and BCL6 on human chromosome 3. Primer binding sites are denoted by arrows and their sequences are presented in S1 Table.
Alberto Martin (12795) +1 more
core +1 more source
, 2020 CRISPR-Cas9 mediated gene editing in induced pluripotent stem cells became an efficient tool to investigate biological mechanisms underlying genetic-driven diseases while accounting for the respective genetic background.
Zoé Hanss (8267268) +4 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Development and testing of a versatile genome editing application reporter (V-GEAR) system
Molecular Therapy: Methods & Clinical DevelopmentCRISPR-Cas9 and novel cas fusion proteins leveraging specific DNA targeting ability combined with deaminases or reverse transcriptases have revolutionized genome editing.
Evan W. Kleinboehl +7 more
doaj +1 more source
Gene disruption rate mediated by using eleven different tRNA promoters in ANEp8-Cas9-gRNA plasmid.
, 2018 Gene disruption rate mediated by using eleven different tRNA promoters in ANEp8-Cas9-gRNA plasmid.
Jean-Paul Ouedraogo (3344108) +4 more
core +1 more source
, 2023 Recently, CRISPR-Cas9-based genome editing has been widely used for plant breeding. In our previous report, a tomato gene encoding hybrid proline-rich protein 1 (HyPRP1), a negative regulator of salt stress responses, has been edited using a CRISPR-Cas9 ...
Ki-Ho Son +29 more
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Genome Biology, 2022 Background Due to post-cleavage residence of the Cas9-sgRNA complex at its target, Cas9-induced DNA double-strand breaks (DSBs) have to be exposed to engage DSB repair pathways.
Si-Cheng Liu +16 more
doaj +1 more source