The Casein Kinase I Family: Roles in Morphogenesis
Developmental Biology, 2001 Wnt signals play important roles in development and oncogenesis and are transduced through at least two pathways: a canonical beta-catenin-dependent and a beta-catenin-independent cascade. Casein kinase I (CKI) is required in both invertebrates and vertebrates to transduce canonical Wnt signals. However, its role in the beta-catenin-independent pathway
McKay, Renée M. +2 more
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Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal. [PDF]
FEBS Lett, 2021 The self-renewal efficiency of mouse embryonic stem cells (ESCs) is determined by the concentration of the transcription factor NANOG. While NANOG binds thousands of sites in chromatin, the regulatory systems that control DNA binding are poorly ...
Mullin NP +5 more
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Mut9p-LIKE KINASE Family Members: New Roles of the Plant-Specific Casein Kinase I in Plant Growth and Development. [PDF]
Int J Mol Sci, 2020 Casein kinase I (CK1), a ubiquitous serine/threonine (Ser/Thr) protein kinase in eukaryotes, plays pivotal roles in a wide spectrum of cellular functions including metabolism, cell cycle progression, developmental control and stress response.
Kang J, Wang Z.
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Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells [PDF]
EMBO Molecular Medicine, 2012 Epithelial ovarian cancer is the leading cause of death among gynaecologic cancers in Western countries. Our studies have shown that casein kinase I‐epsilon (CKIε), a Wnt pathway protein, is significantly overexpressed in ovarian cancer tissues and is ...
Noah Rodriguez +12 more
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Casein Kinase I Isoform Hrr25 Is a Negative Regulator of Haa1 in the Weak Acid Stress Response Pathway in Saccharomyces cerevisiae. [PDF]
Appl Environ Microbiol, 2017 Haa1 is a transcription factor that adapts Saccharomyces cerevisiae cells to weak organic acid stresses by activating the expression of various genes. Many of these genes encode membrane proteins, such as TPO2
Collins ME, Black JJ, Liu Z.
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Casein Kinase I Protein Hrr25 Is Required for Pin4 Phosphorylation and Mediates Cell Wall Integrity Signaling in Saccharomyces cerevisiae. [PDF]
Genes (Basel)Background: Casein kinase I protein Hrr25 plays important roles in many cellular processes, including autophagy, vesicular trafficking, ribosome biogenesis, mitochondrial biogenesis, and the DNA damage response in Saccharomyces cerevisiae.
Bhattarai A, Bhondeley M, Liu Z.
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Identification of <i>Solanum lycopersicum</i> L. Casein Kinase I-like Gene Family and Analysis of Abiotic Stress Response. [PDF]
Genes (Basel)Background: Casein kinase I-like (CKL) protein is a member of the serine/threonine kinase CKI family and plays a pivotal regulatory role in various eukaryotic cellular processes, including stress responses.
Jia M, Xie X, Wang Q, Wang X, Zhang Y.
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Journal of Fungi, 2022 Like many hemibiotrophic plant pathogens, the root-infecting vascular wilt fungus Fusarium oxysporum induces an increase in the pH of the surrounding host tissue.
Melani Mariscal +4 more
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