Results 31 to 40 of about 34,988 (231)
Micafungin-Induced Suicidal Erythrocyte Death
Cellular Physiology and Biochemistry, 2016 Background/Aims: The antifungal drug Micafungin is used for the treatment of diverse fungal infections including candidiasis and aspergillosis. Side effects of Micafungin treatment include microangiopathic hemolytic anemia and thrombocytopenia with ...
Thomas Peter +4 more
doaj +1 more source
Casein Kinase I and Casein Kinase II Differentially Regulate Axin Function in Wnt and JNK Pathways [PDF]
Journal of Biological Chemistry, 2002 Axin uses different combinations of functional domains in down-regulation of the Wnt pathway and activation of the MEKK1/JNK pathway. We are interested in the elucidation of the functional switch of Axin. In the present study, we show that the Wnt activator CKIepsilon, but not CKIIalpha, Frat1, LRP5, or LRP6, inhibited Axin-mediated JNK activation.
Zhang, Y. +5 more
openaire +3 more sources
Enhanced Eryptosis Following Exposure to Dolutegravir
Cellular Physiology and Biochemistry, 2016 Background/Aims: The viral integrase enzyme inhibitor dolutegravir is utilized for the treatment of immunodeficiency virus (HIV) infection. Knowledge on cytotoxicity of dolutegravir is limited.
Abdulla Al Mamun Bhuyan +3 more
doaj +1 more source
Cells, 2022 DNA polymerase β plays a fundamental role in the life cycle of Trypanosoma cruzi since it participates in the kinetoplast DNA repair and replication. This enzyme can be found in two forms in cell extracts of T. cruzi epimastigotes form.
Edio Maldonado +5 more
doaj +1 more source
Purification and characterization of casein kinase I from broccoli [PDF]
Biochemical Journal, 1993 Casein kinase I from broccoli was purified approximately 65,000-fold by chromatography on phosphocellulose, phenyl-Sepharose, CM-Sephacel, and affinity chromatography on N-(2-aminoethyl)-5-chloroisoquinolone-8-sulphonamide (CKI-7)-Sepharose. The catalytic subunit of casein kinase I was identified as a 36-38 kDa polypeptide doublet by using the ...
L J, Klimczak, A R, Cashmore
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Anticancer Alkaloid Lamellarins Inhibit Protein Kinases
Marine Drugs, 2008 Lamellarins, a family of hexacyclic pyrrole alkaloids originally isolated from marine invertebrates, display promising anti-tumor activity. They induce apoptotic cell death through multi-target mechanisms, including inhibition of topoisomerase I ...
Laurent Meijer +8 more
doaj +1 more source
Casein Kinase I in the Mammalian Circadian Clock [PDF]
, 2005 The circadian clock is characterized by daily fluctuations in gene expression, protein abundance, and posttranslational modification of regulatory proteins. The Drosophila PERIOD (dPER) protein is phosphorylated by the serine?threonine protein kinase, DOUBLETIME (DBT). Similarly, the murine PERIOD proteins, mPER1 and mPER2, are phosphorylated by casein
Erik J, Eide +4 more
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A Casein Kinase I Activity Is Constitutively Associated with Nck [PDF]
Journal of Biological Chemistry, 1997 Nck is a 47-kDa cytosolic protein devoid of intrinsic catalytic activity and consisting of Src homology 2 and 3 (SH2 and SH3) domains organized as follows: SH3-SH3-SH3-SH2. Nck is believed to act as an adaptor protein mediating signal transduction initiated by receptor tyrosine kinases (RTKs).
G, Lussier, L, Larose
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eLife, 2022 The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures.
Marina Gonçalves Antunes +5 more
doaj +1 more source
The Casein Kinase I Family in Wnt Signaling
Developmental Biology, 2001 The canonical Wnt-signaling pathway is critical for many aspects of development, and mutations in components of the Wnt pathway are carcinogenic. Recently, sufficiency tests identified casein kinase Iepsilon (CKIepsilon) as a positive component of the canonical Wnt/beta-catenin pathway, and necessity tests showed that CKIepsilon is required in ...
McKay, Renée M. +2 more
openaire +2 more sources