Results 1 to 10 of about 24,063,172 (241)

Caspase-1 activates gasdermin A in non-mammals [PDF]

eLife, 2023
Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E.
Zachary Paul Billman, Stephen Bela Kovacs, Bo Wei, Kidong Kang, Ousmane H Cissé, Edward A Miao   +5 more
doaj   +5 more sources

Adipose tissue IL‐18 production is independent of caspase‐1 and caspase‐11 [PDF]

Immunity, Inflammation and Disease
Background Inflammation in adipose tissue, resulting from imbalanced caloric intake and energy expenditure, contributes to the metabolic dysregulation observed in obesity.
Luis Román‐Domínguez, Jonathan Salazar‐León, Karla F. Meza‐Sosa, Leonor Pérez‐Martínez, Gustavo Pedraza‐Alva   +4 more
doaj   +2 more sources

Salmonella and Caspase-1: a complex interplay of detection and evasion [PDF]

Frontiers in Cellular and Infection Microbiology, 2011
Salmonellae are intracellular pathogens that replicate within epithelial cells and macrophages, and are a significant public health threat in both developed and developing countries.
Edward A Miao, Jayant V Rajan, Jayant V Rajan   +2 more
doaj   +4 more sources

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

Journal of Hematology & Oncology, 2017
Background It is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues indicated that caspase-1 can ...
Ya-feng Li, Gayani Nanayakkara, Yu Sun, Xinyuan Li, Luqiao Wang, Ramon Cueto, Ying Shao, Hangfei Fu, Candice Johnson, Jiali Cheng, Xiongwen Chen, Wenhui Hu, Jun Yu, Eric T. Choi, Hong Wang, Xiao-feng Yang   +15 more
doaj   +2 more sources

Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

Journal of Hematology & Oncology, 2016
Background Caspase-1 is present in the cytosol as an inactive zymogen and requires the protein complexes named “inflammasomes” for proteolytic activation.
Luqiao Wang, Hangfei Fu, Gayani Nanayakkara, Yafeng Li, Ying Shao, Candice Johnson, Jiali Cheng, William Y. Yang, Fan Yang, Muriel Lavallee, Yanjie Xu, Xiaoshu Cheng, Hang Xi, Jonathan Yi, Jun Yu, Eric T. Choi, Hong Wang, Xiaofeng Yang   +17 more
doaj   +2 more sources

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death

Nature Communications, 2016
Inflammatory caspases restrict microbial growth by inducing cytokine production and pyroptosis, but other caspase-induced mechanisms are thought to contribute.
Teresa L. M. Thurston, Sophie A. Matthews, Elliott Jennings, Eric Alix, Feng Shao, Avinash R. Shenoy, Mark A. Birrell, David W. Holden   +7 more
doaj   +2 more sources

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells

Cell Death Discovery, 2022
Histone deacetylase 11 (HDAC11), a sole member of the class IV HDAC subfamily, participates in various cardiovascular diseases. Recent evidence showed that pyroptosis was a form of inflammatory programmed cell death and is critical for atherosclerosis ...
Feng Yao, Zhen Jin, Zihan Zheng, Xiaohan Lv, Lingxuan Ren, Jianjun Yang, Danli Chen, Bo Wang, Wei Yang, Lifang Chen, Weirong Wang, Jianli Gu, R. Lin   +12 more
semanticscholar   +1 more source

Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death

Research, 2022
Inflammasomes are essential complexes of innate immune system, which form the first line of host defense against pathogens. Mounting evidence accumulates that inflammasome signaling is highly correlated with coronavirus disease 2019 (COVID-19).
Xiang Li, Peipei Zhang, Zhiyong Yin, Fei Xu, Zhang-Hua Yang, Jun Jin, Jing, Qu, Zhilong Liu, Hong Qi, Chen-Hui Yao, Jianwei Shuai   +11 more
semanticscholar   +1 more source

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer

International Journal on Biological Sciences, 2021
Cisplatin (DDP) was reported to improve pathological complete response (pCR) rates in triple-negative breast cancer (TNBC) patients, however, the molecular mechanism still remains largely unknown.
Honglin Yan, B. Luo, Xiaoyan Wu, F. Guan, Xinxin Yu, Lina Zhao, Xiaokang Ke, Juan Wu, Jingping Yuan   +8 more
semanticscholar   +1 more source

Caspase-1: The inflammasome and beyond [PDF]

Innate Immunity, 2013
Caspase-1 plays a fundamental role in innate immunity and in several important inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β and proIL-18. Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous and endogenous stressors. More recently, pyroptosis,
Sollberger, Gabriel, Strittmatter, Gerhard E, Garstkiewicz, Martha, Sand, Jennifer, Beer, Hans-Dietmar   +4 more
openaire   +4 more sources