Results 31 to 40 of about 318,537 (297)

Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney

Frontiers in Surgery, 2021
Brain death (BD) induces an organ-level inflammatory response. However, the underlying mechanisms have not been fully elucidated. Here, we investigated the role of caspase-1-mediated pyroptosis in BD-induced kidney injury in rats.
Weifeng Liu, Weifeng Liu, Weifeng Liu, Weifeng Liu, Dongjing Yang, Dongjing Yang, Dongjing Yang, Jihua Shi, Jihua Shi, Jihua Shi, Peihao Wen, Jiakai Zhang, Zhihui Wang, Bowen Hu, Xiaoyi Shi, Shengli Cao, Wenzhi Guo, Wenzhi Guo, Wenzhi Guo, Shuijun Zhang, Shuijun Zhang, Shuijun Zhang   +21 more
doaj   +1 more source

Oligomerized CARD16 promotes caspase‐1 assembly and IL‐1β processing

FEBS Open Bio, 2015
Increasing evidence indicates that caspase recruitment domain (CARD)‐mediated caspase‐1 (CASP1) assembly is an essential process for its activation and subsequent interleukin (IL)‐1β release, leading to the initiation of inflammation.
Tadayoshi Karasawa, Akira Kawashima, Fumitake Usui, Hiroaki Kimura, Koumei Shirasuna, Yoshiyuki Inoue, Takanori Komada, Motoi Kobayashi, Yoshiko Mizushina, Junji Sagara, Masafumi Takahashi   +10 more
doaj   +1 more source

Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases

Journal of Neuroinflammation, 2022
Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and pro-inflammatory mediators (cytokines), including IL‐1β and IL‐18.
Meini Chen, Rong Rong, Xiaobo Xia
doaj   +1 more source

Inflammatory caspase substrate specificities

mBio
Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes such as programmed cell death and inflammation.
Patrick M. Exconde, Christopher M. Bourne, Madhura Kulkarni, Bohdana M. Discher, Cornelius Y. Taabazuing   +4 more
doaj   +1 more source

Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis

Cell & Bioscience, 2019
Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical ...
Xiaoli Huang, Yang Feng, Guanqing Xiong, Shona Whyte, Jing Duan, Yucen Yang, Kaiyu Wang, Shiyong Yang, Yi Geng, Yangping Ou, Defang Chen   +10 more
doaj   +1 more source

A Role for Caspase-1 in Heart Failure [PDF]

Circulation Research, 2007
Apoptosis of cardiomyocytes is increased in heart failure and has been implicated in disease progression. The activation of “proapoptotic” caspases represents a key step in cardiomyocyte apoptosis. In contrast, the role of “proinflammatory” caspases (caspases 1, 4, 5, 11, 12) is unclear. Here, we study the cardiac function of caspase-1.
Sabine, Merkle, Stefan, Frantz, Michael P, Schön, Johann, Bauersachs, Monika, Buitrago, Robert J A, Frost, Eva M, Schmitteckert, Martin J, Lohse, Stefan, Engelhardt   +8 more
openaire   +2 more sources

Characterizing caspase-1 involvement during esophageal disease progression [PDF]

Cancer Immunology, Immunotherapy, 2020
Barrett's esophagus (BE) is an inflammatory condition and a neoplastic precursor to esophageal adenocarcinoma (EAC). Inflammasome signaling, which contributes to acute and chronic inflammation, results in caspase-1 activation leading to the secretion of IL-1β and IL-18, and inflammatory cell death (pyroptosis).
Gillian Barber, Akanksha Anand, null Katarzyna Oficjalska, James J. Phelan, Aisling B. Heeran, Ewelina Flis, Niamh E. Clarke, Jenny A. Watson, Julia Strangmann, Brian Flood, Hazel O’Neill, Dermot O’Toole, Finbar MacCarthy, Narayanasamy Ravi, John V. Reynolds, Elaine W. Kay, Michael Quante, Jacintha O’Sullivan, Emma M. Creagh   +18 more
openaire   +4 more sources

Caspase-1 clipping causes complications for α-synuclein [PDF]

Proceedings of the National Academy of Sciences, 2016
The study of human neurodegeneration has increasingly focused on a clinically diverse group of diseases that share the common pathologic feature of insoluble aggregates of α-synuclein (αSyn) in various populations of neurons and glia. Scientists have begun identifying factors that may initiate or accelerate αSyn aggregation and how this process relates
Silke, Nuber, Dennis J, Selkoe
openaire   +2 more sources

Role of Caspase 1 in Neurologic Disease [PDF]

Archives of Neurology, 2000
In recent years substantial advances have taken place in understanding the mechanistic pathways mediating neuronal cell death in a variety of neurologic diseases. Since the central nervous system (CNS) has little, if any, power of functional neuronal regeneration, prevention of neuronal cell death is an important target of modern neurotherapeutics.
openaire   +2 more sources

The Role of Non-canonical and Canonical Inflammasomes in Inflammaging

Frontiers in Molecular Neuroscience, 2022
Neurodegenerative diseases currently affect millions of people worldwide and continues to increase in the expanding elderly population. Neurodegenerative diseases usually involve cognitive decline and are among the top causes of death.
Brianna Cyr, Roey Hadad, Robert W. Keane, Robert W. Keane, Juan Pablo de Rivero Vaccari, Juan Pablo de Rivero Vaccari   +5 more
doaj   +1 more source