Results 31 to 40 of about 24,095,126 (372)

Caspase-1 interdomain linker cleavage is required for pyroptosis

Life Science Alliance, 2020
The related human NLRP1 and CARD8 form ASC-dependent and ASC-independent inflammasomes, respectively, both of which require pro-caspase-1 interdomain linker processing for the induction of pyroptosis. Pathogen-related signals induce a number of cytosolic
D. Ball, Cornelius Y. Taabazuing, A. R. Griswold, E. L. Orth, Sahana D. Rao, Ilana B. Kotliar, Lauren E Vostal, Darren C. Johnson, D. Bachovchin   +8 more
semanticscholar   +1 more source

Expression of caspase-3, caspase-9, GDF-9 and IGF-1 genes in ovine oocytes cultured with optimum and elevated doses of Amphiregulin, Neuregulin-1 and Tumour necrosis factor-α in-vitro

Indian Journal of Animal Sciences, 2022
The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY, NANDI SUMANTA, GIRISH KUMAR VENKATESH   +2 more
doaj   +1 more source

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Life Science Alliance, 2020
Caspase-1 activation in GSDMD-deficient cells induces a rapid form of caspase-3–dependent secondary necrosis that is licenced by caspase-1–induced Bid cleavage and the release of mitochondrial SMAC.
Rosalie Heilig, Marisa Dilucca, D. Boucher, Kaiwen W. Chen, Dóra Hancz, B. Demarco, K. Shkarina, P. Brož   +7 more
semanticscholar   +1 more source

Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases

Cells, 2022
The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and ...
Christophe Paget, Emilie Doz-Deblauwe, Nathalie Winter, Benoit Briard   +3 more
doaj   +1 more source

AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC

Nature, 2009
The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like receptor members TLR3, TLR7 and TLR8, or by the RNA helicases RIG-I (also known as DDX58) and MDA-5 (IFIH1). Little is known about
V. Hornung, A. Ablasser, M. Charrel-Dennis, F. Bauernfeind, Gabor L Horvath, Daniel R. Caffrey, E. Latz, K. Fitzgerald   +7 more
semanticscholar   +1 more source

Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases

Journal of Inflammation Research, 2020
Caspase-1 is the first and extensively studied inflammatory caspase that is activated through inflammasome assembly. Inflammasome is a cytosolic formation of multiprotein complex that aimed to start inflammatory response against infections or cellular ...
M. Molla, Yonas Akalu, Z. Geto, Baye Dagnew, B. Ayelign, Tewodros Shibabaw   +5 more
semanticscholar   +1 more source

Probiotics Improve Cognitive Impairment by Decreasing Bacteria-Related Pattern Recognition Receptor-Mediated Inflammation in the Gut-Brain Axis of Mice

Journal of Integrative Neuroscience, 2023
Introduction: Some studies have found that probiotics can improve cognitive impairment in Alzheimer’s disease, although the specific molecular mechanism by which this occurs has not been reported.
Xue-Qin Yang, Yang Zhao, Li Xue, Hui-Shan Wang, Jia Zeng, Jun-Rong Du, Zhe Xu   +6 more
doaj   +1 more source

Caspase‐1‐induced pyroptotic cell death [PDF]

Immunological Reviews, 2011
Summary:  Programmed cell death is a necessary part of development and tissue homeostasis enabling the removal of unwanted cells. In the setting of infectious disease, cells that have been commandeered by microbial pathogens become detrimental to the host. When macrophages and dendritic cells are compromised in this way, they can be lysed by pyroptosis,
Edward A. Miao, Jayant V. Rajan, Jayant V. Rajan, Alan Aderem   +3 more
openaire   +2 more sources

Defusing inflammasomes. [PDF]

, 2018
In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation.
Sandstrom, Andrew, VANCE, Russell E.
core   +1 more source

Caspase‐1 is not involved in experimental hepatitis in mouse [PDF]

FEBS Letters, 1999
Experimental hepatitis induced by tumor necrosis factor in d‐(+)‐galactosamine‐sensitized mice or by an agonistic anti‐Fas antibody in normal mice is accompanied by dramatic apoptosis of hepatocytes. Apoptosis is the final result of activation of a cascade of caspases.
Peter Brouckaert, Claude Libert, Wim Van Molle   +2 more
openaire   +3 more sources