Results 41 to 50 of about 24,095,126 (372)

Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release [PDF]

, 2017
Aims: Calcium phosphate (CaP) particle deposits are found in several inflammatory diseases including atherosclerosis and osteoarthritis. CaP, and other forms of crystals and particles, can promote inflammasome formation in macrophages leading to caspase ...
Afonina, Alexander N. Kapustin, Alfaidi, Bailet, Baroja-Mazo, Bautista Nino, Bennett, Burton, Catherine M. Shanahan, Chen, Cilla, Coopman, Cossetti, Cullen, Cunningham, Dautova, Diane Proudfoot, Duewell, Ehara, Erlinge, Ewence, Feil, Fuerst, Furman, Gross, Hanneke Okkenhaug, Hendriks, Hilgendorf, Hutcheson, Irkle, Iyemere, Jin, Kalra, Kapustin, Kevin Pappert, Kistowska, Krisenko, Laliberte, LaRocca, Lau, Li, Liu, Liu, Luga, Maldonado, Martin, Martin D. Bootman, Matthias Epple, Mfunyi, Migita, Mocsai, Molloy, Morgan, Nadra, Nakahara, Narayan, Ng, Pazar, Piccioli, Pugliese, Qu, Ragnauth, Ridker, Ruiz, Scimeca, Shamaa, Simon J. Cook, Smith, Song, Swaan, Vengrenyuk, Vigano, Virmani, Wang, Webber, Yana Dautova, Young   +76 more
core   +2 more sources

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]

, 2017
The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke, Demon, Dieter, Gonçalves, Amanda, Hochepied, Tino, Kanneganti, Thirumala-Devi, Krautwald, Stefan, Lamkanfi, Mohamed, Matusiak, Magdalena, Moraes de Vasconcelos, Nathalia, Van Gorp, Hanne, Van Hauwermeiren, Filip, Van Opdenbosch, Nina, Vande Walle, Lieselotte, Verdonckt, Maarten, Viana Saavedra, Pedro Henrique   +14 more
core   +2 more sources

Pseudomonas aeruginosa pilin activates the inflammasome [PDF]

, 2011
IL-1 beta is produced from inactive pro-IL-1 beta by activation of caspase-1 brought about by a multi-subunit protein platform called the inflammasome. Many bacteria can trigger inflammasome activity through flagellin activation of the host protein NLRC4.
Agostini, Andersen-Nissen, Arora, Auron, Bergsbaken, Bird, Bitter, Case, Choi, Cornelis, Craig, Dinarello, Evans, Franchi, Franchi, Franchi, Hahn, Hazes, Hsu, Johnson, Kanneganti, Kus, Lightfield, Lindestam Arlehamn, Liu, Marathe, Mariathasan, Mariathasan, Martinon, Martinon, Mattick, Miao, Miao, Miao, Murray, Muruve, Neyt, O'Neill, Perkins, Pier, Proft, Sato, Sato, Sawa, Schroeder, Semmler, Smedley, Sutterwala, Sutterwala, Thornberry, Ting, Vallis, von Götz, Ye, Yu   +54 more
core   +1 more source

Caspase-1 inflammasomes in infection and inflammation [PDF]

Journal of Leukocyte Biology, 2007
AbstractNucleotide-binding and oligomerization domain-like receptors (NLRs) constitute a family of germline-encoded pattern-recognition receptors, which allow the host to respond rapidly to a wide variety of pathogenic microorganisms. Here, we discuss recent advances in the study of a subset of NLRs, which control the activation of caspase-1 through ...
Lamkanfi, Mohamed, Kanneganti, Thirumala‐devi, Franchi, Luigi, Núñez, Gabriel   +3 more
openaire   +4 more sources

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent [PDF]

, 2014
Infection of the mammary gland with live bacteria elicits a pathogen-specific host inflammatory response. To study these host-pathogen interactions wild type mice, NF-kappaB reporter mice as well as caspase-1 and IL-1beta knockout mice were ...
A Ito, B Brand, C Coeshott, C Kebaier, C Riollet, D Demon, D Demon, Dario S. Zamboni, DD Bannerman, Dieter Demon, DJ Hazuda, E Brouillette, E Gonen, EM Ibeagha-Awemu, Evelyne Meyer, F Li, H Carlsen, Harald Carlsen, HW Barkema, J Gunther, J Mehrzad, J Monks, K Demeyere, K Farhat, K Jensen, K Persson-Waller, Koen Breyne, Kristel Demeyere, KW Kim, L Connelly, L Lara-Zárate, M Lamkanfi, M Rinaldi, M Wittmann, MG Stevens, Niek N. Sanders, OC Kousidou, Peter Vandenabeele, RA Black, S Balasubramanian, S Bougarn, S Elazar, S Elazar, S Liu, S Mandard, S Notebaert, S Notebaert, S Notebaert, SK Cool, Steven K. Cool, TC Lin, Tom Vandenberghe, U Meyer-Hoffert, U Schonbeck, W Yang, Wim Van Den Broeck, X Li, YH Schukken   +57 more
core   +5 more sources

Caspase-1 initiates apoptosis in the absence of gasdermin D

Nature Communications, 2019
Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis, which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still susceptible to caspase-1-mediated cell death.
K. Tsuchiya, S. Nakajima, S. Hosojima, Dinh Thi Nguyen, T. Hattori, Thuong Manh Le, O. Hori, M. Mahib, Y. Yamaguchi, M. Miura, T. Kinoshita, Hiroko Kushiyama, Mayumi Sakurai, T. Shiroishi, T. Suda   +14 more
semanticscholar   +1 more source

Activation of Caspase-1 in the Nucleus Requires Nuclear Translocation of Pro-caspase-1 Mediated by Its Prodomain [PDF]

Journal of Biological Chemistry, 1998
The interleukin-1beta-converting enzyme-like protease precursor, pro-caspase-1, has an N-terminal prodomain that is removed during cleavage activation of the protease. Here we show that tumor necrosis factor treatment of HeLa cells induced apoptosis without detectable proteolytic activation of caspase-1 in the cytosol.
Mao, P.-L., Jiang, Y., Wee, B.Y., Porter, A.G.   +3 more
openaire   +3 more sources

Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections

Cell Reports, 2021
Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly ...
Zsofi Digby, Panagiotis Tourlomousis, James Rooney, Joseph P. Boyle, Betsaida Bibo-Verdugo, Robert J. Pickering, Steven J. Webster, Thomas P. Monie, Lee J. Hopkins, Nobuhiko Kayagaki, Guy S. Salvesen, Soren Warming, Lucy Weinert, Clare E. Bryant   +13 more
doaj  

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

Journal of Experimental Medicine, 2018
Host-protective caspase-1 activity must be tightly regulated to prevent pathology, but mechanisms controlling the duration of cellular caspase-1 activity are unknown.
D. Boucher, Mercedes Monteleone, Rebecca C. Coll, Kaiwen W. Chen, Connie M. Ross, Jessica L. Teo, Guillermo A. Gomez, Caroline L. Holley, Damien Bierschenk, K. Stacey, A. Yap, Jelena S. Bezbradica, K. Schroder   +12 more
semanticscholar   +1 more source

Caspase-1 Mediates Resistance in Murine Melioidosis [PDF]

Infection and Immunity, 2009
ABSTRACT The gram-negative rod Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease which is endemic in tropical and subtropical areas. The bacterium multiplies intracellularly within the cytosol, induces the formation of actin tails, and can spread directly from ...
Gladys Tan, Yunn-Hwen Gan, Kristin Eske, Yichun Liu, Jens Köhler, Patimaporn Wongprompitak, Patimaporn Wongprompitak, Guang Wen Sun, Ivo Steinmetz, Katrin Breitbach   +9 more
openaire   +3 more sources