Results 51 to 60 of about 24,095,126 (372)
Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation [PDF]
, 2016 Inflammasome activation, with subsequent release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, has recently been implicated in atherosclerosis-associated inflammation. This study aims to assess in acute coronary syndrome (ACS) patients (
Christina Bursill +8 more
core +1 more source
Alpha 1-antitrypsin does not inhibit human monocyte caspase-1. [PDF]
PLoS ONE, 2015 BACKGROUND:Alpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also been reported to have immune ...
Mohd Akhlakur Rahman +3 more
doaj +1 more source
NALP3: a key player in caspase-1 activation [PDF]
Journal of Endotoxin Research, 2006 The NLR (NACHT-LRR) family of proteins have been implicated in the regulation of immune responses and cell death pathways. Some NLR family members can form multiprotein complexes, called inflammasomes, involved in the activation of pro-inflammatory caspases.
Yasunori Ogura +4 more
openaire +3 more sources
Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes. [PDF]
, 2017 Inflammasomes regulate microglial caspase-1 activation and subsequent neuroinflammatory processes in brain pathology. In the present study, we have identified inflammasomes causing caspase-1 activation following stimulation of microglia with ...
Eder, C, Scholz, H
core +1 more source
IL-1R and inflammasomes mediate early pulmonary protective mechanisms in respiratory brucella abortus infection [PDF]
, 2016 Brucella spp. infection is frequently acquired through contaminated aerosols. The role of interleukin-1 beta (IL-1β) in the early pulmonary response to respiratory Brucella infection is unknown.
Alonso Paiva, Iván Mathias +9 more
core +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance The pore-forming protein gasdermin D (GSDMD) was recently identified as the principal executioner of pyroptosis (“fiery death”), a type of proinflammatory programmed cell death driven by inflammasomes.
Brienne A. McKenzie +8 more
semanticscholar +1 more source
Role of Caspase 1 in Neurologic Disease [PDF]
Archives of Neurology, 2000 In recent years substantial advances have taken place in understanding the mechanistic pathways mediating neuronal cell death in a variety of neurologic diseases. Since the central nervous system (CNS) has little, if any, power of functional neuronal regeneration, prevention of neuronal cell death is an important target of modern neurotherapeutics.
openaire +3 more sources
Investigation of caspase-1 activity and interleukin-1β production in murine macrophage cell lines infected with Leishmania major [PDF]
, 2014 ObjectiveTo investigate the caspase-1 dependent inflammatory pathway activity and interleukin-1β (IL-1β) secretion in murine macrophage cell lines J774G8 infected with Leishmania major (L.
Aghamollaei, Hossein +5 more
core +1 more source
Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney
Frontiers in Surgery, 2021 Brain death (BD) induces an organ-level inflammatory response. However, the underlying mechanisms have not been fully elucidated. Here, we investigated the role of caspase-1-mediated pyroptosis in BD-induced kidney injury in rats.
Weifeng Liu +21 more
doaj +1 more source
Cell Death and Disease, 2019 Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients receiving high-dose propofol. High-dose propofol treatment with a prolonged duration can damage the immune system.
Lingbin Sun +7 more
semanticscholar +1 more source