Results 51 to 60 of about 341,145 (337)

Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis

Kidney & Blood Pressure Research, 2016
Background/Aims: Caspases, an evolutionary conserved family of aspartate-specific cystein proteases, play pivotal roles in apoptotic and inflammatory signaling.
You Ke, Hui Tang, Chen Ye, Chun-Tao Lei, Yu-Mei Wang, Hua Su, Chun Zhang, Hua-Jun Jiang   +7 more
doaj   +1 more source

Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1. [PDF]

PLoS ONE, 2015
Mononuclear phagocytes utilize caspase-1 activation as a means to respond to danger signals. Although caspase-1 was discovered using highly concentrated cell extracts that spontaneously activate caspase-1, it is now clear that in live cell models caspase-
Obada R Shamaa, Srabani Mitra, Mikhail A Gavrilin, Mark D Wewers   +3 more
doaj   +1 more source

Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney

Frontiers in Surgery, 2021
Brain death (BD) induces an organ-level inflammatory response. However, the underlying mechanisms have not been fully elucidated. Here, we investigated the role of caspase-1-mediated pyroptosis in BD-induced kidney injury in rats.
Weifeng Liu, Weifeng Liu, Weifeng Liu, Weifeng Liu, Dongjing Yang, Dongjing Yang, Dongjing Yang, Jihua Shi, Jihua Shi, Jihua Shi, Peihao Wen, Jiakai Zhang, Zhihui Wang, Bowen Hu, Xiaoyi Shi, Shengli Cao, Wenzhi Guo, Wenzhi Guo, Wenzhi Guo, Shuijun Zhang, Shuijun Zhang, Shuijun Zhang   +21 more
doaj   +1 more source

New exit: caspase-1 for secretion [PDF]

The Journal of Cell Biology, 2008
Acaspase activates secretion of many inflammatory response proteins without signal sequences, say Martin Keller, Hans-Dietmar Beer, and colleagues (Swiss Federal Institute of Technology, Zurich, Switzerland), revealing a new pathway for secretion.
openaire   +2 more sources

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]

, 2015
Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky, Demon, Dieter, Janssens, Sophie, Lamkanfi, Mohamed, Lornet, Guillaume, Timmerman, Vincent, Ydens, Elke   +6 more
core   +2 more sources

Oligomerized CARD16 promotes caspase‐1 assembly and IL‐1β processing

FEBS Open Bio, 2015
Increasing evidence indicates that caspase recruitment domain (CARD)‐mediated caspase‐1 (CASP1) assembly is an essential process for its activation and subsequent interleukin (IL)‐1β release, leading to the initiation of inflammation.
Tadayoshi Karasawa, Akira Kawashima, Fumitake Usui, Hiroaki Kimura, Koumei Shirasuna, Yoshiyuki Inoue, Takanori Komada, Motoi Kobayashi, Yoshiko Mizushina, Junji Sagara, Masafumi Takahashi   +10 more
doaj   +1 more source

Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis

Cell & Bioscience, 2019
Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical ...
Xiaoli Huang, Yang Feng, Guanqing Xiong, Shona Whyte, Jing Duan, Yucen Yang, Kaiyu Wang, Shiyong Yang, Yi Geng, Yangping Ou, Defang Chen   +10 more
doaj   +1 more source

Inflammatory caspase substrate specificities

mBio
Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes such as programmed cell death and inflammation.
Patrick M. Exconde, Christopher M. Bourne, Madhura Kulkarni, Bohdana M. Discher, Cornelius Y. Taabazuing   +4 more
doaj   +1 more source

TLR4 and NLRP3 Caspase 1- IL-1β- Axis are not Involved in Colon Ascendens Stent Peritonitis (Casp)-Associated Heart Disease [PDF]

, 2018
Hemodynamic collapse and myocardial dysfunction are among the major causes ofdeath in severe sepsis. The purpose of this study was to assess the role played by TLR4and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after ...
Branda, Hugo Justino, Carvalho, Adriana Bastos, Fernandez Ruocco, Maria Julieta, Ferreira, Fabiano, López Alarcón, Maria Micaela, Medei, Emiliano, Neto Paiva, Claudia, Paula Neto, Heitor A., Peroba Ramos, Isalira, Sepúlveda, Marisa Noemí, Vila Petroff, Martin Gerarde   +10 more
core   +2 more sources

Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases

Journal of Neuroinflammation, 2022
Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and pro-inflammatory mediators (cytokines), including IL‐1β and IL‐18.
Meini Chen, Rong Rong, Xiaobo Xia
doaj   +1 more source