Results 61 to 70 of about 24,095,126 (372)
The mutualistic fungus Piriformospora indica colonizes Arabidopsis roots by inducing an endoplasmic reticulum stress-triggered caspase-dependent cell death [PDF]
, 2012 In Arabidopsis thaliana roots, the mutualistic fungus Piriformospora indica initially colonizes living cells, which die as the colonization proceeds. We aimed to clarify the molecular basis of this colonization-associated cell death.
Kogel, Karl-Heinz +4 more
core +2 more sources
Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis
Kidney & Blood Pressure Research, 2016 Background/Aims: Caspases, an evolutionary conserved family of aspartate-specific cystein proteases, play pivotal roles in apoptotic and inflammatory signaling.
You Ke +7 more
doaj +1 more source
Nature Communications, 2018 Alzheimer's disease (AD) is an intractable progressive neurodegenerative disease characterized by cognitive decline and dementia. An inflammatory neurodegenerative pathway, involving Caspase-1 activation, is associated with human age-dependent cognitive ...
Joseph Flores +5 more
semanticscholar +1 more source
Caspase-1 Modulates Incisional Sensitization and Inflammation [PDF]
Anesthesiology, 2010 Background Surgical injury induces production and release of inflammatory mediators in the vicinity of the wound. They in turn trigger nociceptive signaling to produce hyperalgesia and pain. Interleukin-1β plays a crucial role in this process.
David C. Yeomans +7 more
openaire +3 more sources
Oligomerized CARD16 promotes caspase‐1 assembly and IL‐1β processing
FEBS Open Bio, 2015 Increasing evidence indicates that caspase recruitment domain (CARD)‐mediated caspase‐1 (CASP1) assembly is an essential process for its activation and subsequent interleukin (IL)‐1β release, leading to the initiation of inflammation.
Tadayoshi Karasawa +10 more
doaj +1 more source
Cell & Bioscience, 2019 Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical ...
Xiaoli Huang +10 more
doaj +1 more source
Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases
Journal of Neuroinflammation, 2022 Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and pro-inflammatory mediators (cytokines), including IL‐1β and IL‐18.
Meini Chen, Rong Rong, Xiaobo Xia
doaj +1 more source
Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1‐caspase‐1 axis
EMBO Journal, 2018 Viral infection triggers host innate immune responses, which primarily include the activation of type I interferon (IFN) signaling and inflammasomes.
Yanyan Zheng +9 more
semanticscholar +1 more source
New exit: caspase-1 for secretion [PDF]
The Journal of Cell Biology, 2008 Acaspase activates secretion of many inflammatory response proteins without signal sequences, say Martin Keller, Hans-Dietmar Beer, and colleagues (Swiss Federal Institute of Technology, Zurich, Switzerland), revealing a new pathway for secretion.
openaire +2 more sources
Roles of caspase-1 in Listeria infection in mice [PDF]
International Immunology, 2004 Caspase-1 [IL-1beta-converting enzyme (ICE)] processes substrate precursor molecules to yield the biologically active form of IL-1beta and IL-18, both of which are considered to play important roles in the host defense by activation of both innate and adaptive immunity.
Ekihiro Seki +6 more
openaire +3 more sources