Results 61 to 70 of about 341,145 (337)

Role of caspase-1 in regulation of triglyceride metabolism [PDF]

Proceedings of the National Academy of Sciences, 2013
Caspase-1 is a cysteine protease that can be activated by both endogenous and exogenous inflammatory stimuli and has been shown to have important functions in processes as diverse as proteolytic activation of cytokines, cell death, and membrane repair. Caspase-1–dependent production of the inflammatory cytokines IL-1 and IL-18 has also been implicated ...
Ruslan Medzhitov, Gerald I. Shulman, Michael J. Jurczak, Maya E. Kotas, Charles Annicelli, Matthew P. Gillum, Gary W. Cline   +6 more
openaire   +3 more sources

IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]

, 2014
The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S, Bulek, Katarzyna, Dubyak, George, Fitzgerald, Katherine A, Franchi, Luigi, Gulen, Muhammet F, Herjan, Tomasz, Hu, Yinling, Karin, Michael, Klinman, Dennis, Li, Xiaoxia, Martin, Bradley N, Narla, Goutham, Nuñez, Gabriel, Sato, Takashi, Thomas, James, Wang, Chenhui, Willette-Brown, Jami, Zhong, Xiao-Ping, Zhou, Hao   +19 more
core   +1 more source

A Signal for the Caspase-1 Inflammasome Free of TLR [PDF]

Immunity, 2007
Secretion of the proinflammatory cytokine IL-1beta requires caspase-1 and Toll-like receptor (TLR) signaling. However, Kanneganti et al. (2007) find that bacteria can use pore-forming mechanisms to activate caspase-1 for the production of IL-1beta precursor independently of TLRs.
openaire   +3 more sources

Salmonella and Caspase-1: A complex Interplay of Detection and Evasion [PDF]

Frontiers in Microbiology, 2011
Salmonellae are intracellular pathogens that replicate within epithelial cells and macrophages, and are a significant public health threat in both developed and developing countries. The innate immune system detects microbes through pattern recognition receptors, which are compartmentalized on the subcellular level to detect either extracellular (e.g.,
Edward A. Miao, Jayant V. Rajan, Jayant V. Rajan   +2 more
openaire   +4 more sources

The Role of Non-canonical and Canonical Inflammasomes in Inflammaging

Frontiers in Molecular Neuroscience, 2022
Neurodegenerative diseases currently affect millions of people worldwide and continues to increase in the expanding elderly population. Neurodegenerative diseases usually involve cognitive decline and are among the top causes of death.
Brianna Cyr, Roey Hadad, Robert W. Keane, Robert W. Keane, Juan Pablo de Rivero Vaccari, Juan Pablo de Rivero Vaccari   +5 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Novack, Deborah V, Qu, Chao, Ricci, Biancamaria, Wang, Chun, Xiao, Jianqiu, Zou, Wei   +9 more
core   +2 more sources

Adipose tissue IL‐18 production is independent of caspase‐1 and caspase‐11

Immunity, Inflammation and Disease
Background Inflammation in adipose tissue, resulting from imbalanced caloric intake and energy expenditure, contributes to the metabolic dysregulation observed in obesity.
Luis Román‐Domínguez, Jonathan Salazar‐León, Karla F. Meza‐Sosa, Leonor Pérez‐Martínez, Gustavo Pedraza‐Alva   +4 more
doaj   +1 more source

SARS-CoV-2 induces “cytokine storm” hyperinflammatory responses in RA patients through pyroptosis

Frontiers in Immunology, 2022
BackgroundThe coronavirus disease (COVID-19) is a pandemic disease that threatens worldwide public health, and rheumatoid arthritis (RA) is the most common autoimmune disease.
Qingcong Zheng, Rongjie Lin, Yuchao Chen, Qi Lv, Jin Zhang, Jingbo Zhai, Weihong Xu, Wanming Wang   +7 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source