Caspase-11 signaling enhances graft-versus-host disease [PDF]
Nature Communications, 2019 An increasing number of inflammatory pathologies is associated with IL-1 production downstream of caspases 1 and 11. Here the authors show that graft-versus-host-disease (GvHD) is diminished in mice with genetic or pharmacological ablation of caspase-11,
Yanyan Lu +15 more
doaj +3 more sources
Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense
Cell Reports, 2021 Summary: Caspase-11 sensing of intracellular lipopolysaccharide (LPS) plays critical roles during infections and sepsis. However, the key cell types that sense intracellular LPS and their contributions to the host responses at the organismal level are ...
Puja Kumari +4 more
doaj +2 more sources
Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells. [PDF]
Cell Mol Gastroenterol Hepatol, 2023 Zhang Q +8 more
europepmc +2 more sources
cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis [PDF]
Science Advances, 2019 Targeting immunometabolism is a strategy to prevent infection-mediated septic death. The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11–dependent nonclassical inflammasome is intricately controlled to avoid excessive inflammatory ...
Ruochan Chen +10 more
semanticscholar +3 more sources
Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11 [PDF]
Nature, 2021 Mouse caspase-11 and human caspase-4 and caspase-5 recognize cytosolic lipopolysaccharide (LPS) to induce pyroptosis by cleaving the pore-forming protein GSDMD1-5. This non-canonical inflammasome defends against Gram-negative bacteria6,7. Shigella flexneri, which causes bacillary dysentery, lives freely within the host cytosol where these caspases ...
Zilin Li +12 more
semanticscholar +3 more sources
Crystal structure of caspase-11 CARD provides insights into caspase-11 activation. [PDF]
Cell Discov, 2020 AbstractMurine caspase-11 is the centerpiece of the non-canonical inflammasome pathway that can respond to intracellular LPS and induce pyroptosis. Caspase-11 contains two components, an N-terminal caspase recruitment domain (CARD) and a C-terminal catalytic domain.
Liu M +14 more
europepmc +4 more sources
AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis [PDF]
Frontiers in Immunology, 2019 Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and ...
Ruochan Chen +9 more
doaj +3 more sources
Cell Reports, 2021 Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly ...
Zsofi Digby +13 more
doaj +1 more source
Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria
Frontiers in Immunology, 2022 Inflammatory caspases detect cytosol-invasive Gram-negative bacteria by monitoring for the presence of LPS in the cytosol. This should provide defense against the cytosol-invasive Burkholderia and Shigella species by lysing the infected cell via ...
Carissa K. Harvest +6 more
doaj +1 more source
GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages
Frontiers in Cellular and Infection Microbiology, 2023 Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not ...
Ping Jiang +10 more
doaj +1 more source