Results 41 to 50 of about 4,015,701 (290)
Endosymbiotic RNA virus inhibits Leishmania-induced caspase-11 activation [PDF]
iScience, 2021 New World species of the intracellular protozoan parasites of the Leishmania genus can cause mucocutaneous leishmaniases. The presence of an endosymbiotic Leishmania RNA virus (LRV) in Leishmania guyanensis (L.g.) promotes disease exacerbation and the development of mucocutaneous disease.
Renan V.H. de Carvalho +3 more
openaire +3 more sources
Cells, 2022 The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and ...
Christophe Paget +3 more
doaj +1 more source
Revisiting Caspase-11 Function in Host Defense [PDF]
Cell Host & Microbe, 2013 Proinflammatory caspases play important roles in innate immunity. Much attention has focused on caspase-1, which acts to eliminate pathogens by obliterating their replicative niches as well as alerting the host to their presence. Now, emerging data have shed light on the lesser-studied proinflammatory caspase-11 in the combat between host and pathogens.
Ng, Tessie M., Monack, Denise M.
openaire +2 more sources
Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium
Cell Reports, 2020 Summary: Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis, eliminating intracellular replication niches. We previously showed that macrophages detect Burkholderia thailandensis via NLRC4, triggering the release of interleukin (IL)
Stephen B. Kovacs +6 more
doaj +1 more source
Shigella OspC3 suppresses murine cytosolic LPS sensing
iScience, 2021 Summary: Shigella flexneri, a cytosol-invasive gram-negative pathogen, deploys an array of type III-secreted effector proteins to evade host cell defenses.
Changhoon Oh +4 more
doaj +1 more source
Caspase-11: The Noncanonical Guardian of Cytosolic Sanctity [PDF]
Cell Host & Microbe, 2013 Caspase-11 controls a noncanonical inflammasome that responds to Gram-negative bacteria and certain pore-forming toxins. Aachoui et al. (2013) and Case et al. (2013) identify a role for caspase-11 in rapid responses to bacterial pathogens that access the cytosol via vacuolar membrane disruption or the activity of specialized secretion systems.
Shin, Sunny, Brodsky, Igor E.
openaire +2 more sources
Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties.
Immunity, 2021 Heparin, a mammalian polysaccharide, is a widely used anticoagulant medicine to treat thrombotic disorders. It is also known to improve outcomes in sepsis, a leading cause of mortality resulted from infection-induced immune dysfunction.
Yiting Tang +16 more
semanticscholar +1 more source
Current Molecular Pharmacology, 2023 AIM In the present study, we aimed to investigate the effects of Fenbufen treatment on the SAP model induced by caerulein and lipopolysaccharide. BACKGROUND Severe acute pancreatitis (SAP) is an extremely dangerous disease with high mortality, which is
Rong Wan +11 more
semanticscholar +1 more source
Journal of investigative surgery, 2023 Background: Acute kidney injury (AKI) is a common complication in patients with severe acute pancreatitis (SAP). Caspase-11-mediated pyroptosis is essential for the progression of multiple diseases, but its role in SAP-induced AKI remains unknown.
Yang Shao +6 more
semanticscholar +1 more source
Pyroptosis: Caspase-11 Unlocks the Gates of Death [PDF]
Immunity, 2015 How inflammatory caspases trigger pyroptotic cell death is mostly unexplained. In this issue of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-dependent pyroptosis.
de Gassart, Aude, Martinon, Fabio
openaire +2 more sources