Stearoyl Lysophosphatidylcholine Inhibits Endotoxin-Induced Caspase-11 Activation [PDF]
Shock, 2018 Stearoyl lysophosphatidylcholine (LPC) exerts protective effect during endotoxemia and in experimental sepsis, but the underlying mechanism is unclear. Here, we demonstrated that stearoyl LPC could block caspase-11-mediated macrophage pyroptosis.
Wenbo, Li +9 more
openaire +2 more sources
Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney
Frontiers in Surgery, 2021 Brain death (BD) induces an organ-level inflammatory response. However, the underlying mechanisms have not been fully elucidated. Here, we investigated the role of caspase-1-mediated pyroptosis in BD-induced kidney injury in rats.
Weifeng Liu +21 more
doaj +1 more source
Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection [PDF]
, 2014 Enteropathogenic and enterohemorrhagic bacterial infections in humans are a severe cause of morbidity and mortality. Although NOD-like receptors (NLRs) NOD2 and NLRP3 have important roles in the generation of protective immune responses to enteric ...
Anand, Paras K +6 more
core +3 more sources
Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]
, 2017 International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu +10 more
core +4 more sources
Frontiers in Cellular and Infection Microbiology, 2022 Sepsis is a significant cause of mortality in critically ill patients. Acute lung injury (ALI) is a leading cause of death in these patients. Endothelial cells exposed to the bacterial endotoxin lipopolysaccharide (LPS) can progress into pyroptosis, a ...
Rui Yang, Xiaojuan Zhang
semanticscholar +1 more source
Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María +3 more
core +1 more source
The involvement of caspase‐11 in TPEN‐induced apoptosis [PDF]
FEBS Letters, 2008 The depletion of intracellular zinc with N,N,N′,N′‐tetrakis(2‐pyridylmethyl)ethylenediamine (TPEN) induces protein synthesis‐dependent apoptosis. Here we examined the involvement of caspase induction in apoptosis. Among the examined caspases, only caspase‐11 was increased by TPEN.
Lee, Jong-Min +6 more
openaire +2 more sources
Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer : diagnostic and therapeutic potential [PDF]
, 2015 Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis.
Caiazza, F +12 more
core +2 more sources
Pyroptotic and non-pyroptotic effector functions of caspase-11. [PDF]
Immunol Rev, 2020 AbstractInnate immune cells, epithelial cells, and many other cell types are capable of detecting infection or tissue injury, thus mounting regulated immune response. Inflammasomes are highly sophisticated and effective orchestrators of innate immunity.
Abu Khweek A, Amer AO.
europepmc +4 more sources
Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response [PDF]
, 2015 We recently demonstrated that the secreted aspartyl proteinases (Saps), Sap2 and Sap6, of Candida albicans have the potential to induce the canonical activation of NLRP3-inflammasome leading to the secretion of IL-1β and IL-18 via caspase-1 activation ...
Gabrielli E +8 more
core +1 more source