The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion. [PDF]
PLoS Pathogens, 2022 A hallmark of Entamoeba histolytica (Eh) invasion in the gut is acute inflammation dominated by the secretion of pro-inflammatory cytokines TNF-α and IL-1β.
Shanshan Wang +2 more
doaj +3 more sources
Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis [PDF]
EMBO Molecular Medicine, 2019 Human caspase‐4 and its mouse homolog caspase‐11 are receptors for cytoplasmic lipopolysaccharide. Activation of the caspase‐4/11‐dependent NLRP3 inflammasome is required for innate defense and endotoxic shock, but how caspase‐4/11 is modulated remains ...
Jye‐Lin Hsu +9 more
doaj +6 more sources
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients [PDF]
Journal of Experimental & Clinical Cancer Research, 2020 Background Therapy/prognosis of Non-Small Cell Lung Cancer (NSCLC) patients are strongly related to gene alteration/s or protein expression. However, more than 50% of NSCLC patients are negative to key drugable biomarkers.
Michela Terlizzi +11 more
doaj +3 more sources
Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome [PDF]
The Journal of Immunology, 2020 Abstract Inflammasomes are multiprotein complexes of the innate immune system that orchestrate development of inflammation by activating the secretion of proinflammatory cytokines, IL-1β and IL-18. The LPS of Gram-negative bacteria have been shown to activate a novel, noncanonical inflammasome by directly binding in the cytosol to human ...
Sampsa Matikainen +2 more
semanticscholar +4 more sources
Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme. [PDF]
Life Sci Alliance, 2023 The noncanonical inflammasome is a signalling complex critical for cell defence against cytosolic Gram-negative bacteria. A key step in the human noncanonical inflammasome pathway involves unleashing the proteolytic activity of caspase-4 within this complex. Caspase-4 induces inflammatory responses by cleaving gasdermin-D (GSDMD) to initiate pyroptosis;
Chan AH +9 more
europepmc +4 more sources
Structural insights into cytokine cleavage by inflammatory caspase-4
Nature, 2023 Inflammatory caspases are key enzymes in mammalian innate immunity that control the processing and release of interleukin-1 (IL-1)-family cytokines1,2. Despite the biological importance, the structural basis for inflammatory caspase-mediated cytokine processing has remained unclear.
Pascal Devant +6 more
openaire +3 more sources
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. [PDF]
Nat Immunol, 2020 Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unknown. Here we show that in interferon-γ-stimulated cells guanylate-binding proteins (GBPs) assemble on the ...
Wandel MP +11 more
europepmc +7 more sources
GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity [PDF]
Journal of Molecular Cell Biology, 2018 Abstract Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death.
Qin, Chen +11 more
openaire +3 more sources
Caspase-4: A Therapeutic Target for Peptic Ulcer Disease [PDF]
ImmunoHorizons, 2020 Abstract Peptic ulcers are caused by the interaction between bacterial and host factors. This study demonstrates enhanced expression of caspase-4 in peptic ulcer patient biopsies, indicating that pyroptosis and noncanonical inflammasome activity may be processes involved in peptic ulcer disease.
Zbigniew Zaslona +9 more
openaire +3 more sources
Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells [PDF]
Mucosal Immunology, 2017 The human pathogen enteropathogenic Escherichia coli (EPEC), as well as the mouse pathogen Citrobacter rodentium, colonize the gut mucosa via attaching and effacing lesion formation and cause diarrheal diseases. EPEC and C.
Berger, C. N. +9 more
core +8 more sources