Results 21 to 30 of about 12,127,416 (284)

Caspase-4 disaggregates lipopolysaccharide micelles via LPS-CARD interaction [PDF]

Scientific Reports, 2019
AbstractLipopolysaccharides (LPS) are a major component of the outer membrane of Gram-negative bacteria and are pathogen-associated molecular patterns recognized by the TLR4/MD2 complex that induces an inflammatory response. Recently, the cytosolic receptors caspase-4/-5/-11 that bind LPS inside the cell and trigger inflammasome activation or ...
Jinsu An, Seong Ho Kim, Dohyeon Hwang, Kyung Eun Lee, Min Jung Kim, Eun Gyeong Yang, So Yeon Kim, Hak Suk Chung   +7 more
openaire   +3 more sources

Apaf-1/caspase-4 pyroptosome: a mediator of mitochondrial permeability transition-triggered pyroptosis. [PDF]

Signal Transduct Target Ther, 2021
In a recent paper in Cell Metabolism, Xu et al. provide new insights whether and how caspase-4/11 involves in pyroptotic cell death implicated in noninfective diseases. They discovered a novel mechanism of GSDME-dependent pyroptosis, which was induced by
Shao G, Wang L, Wang X, Fu C.
europepmc   +6 more sources

Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains [PDF]

Acta Neuropathologica, 2019
The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and other neurological disorders. However, most transgenic TDP-43 rodent models show predominant nuclear distribution of TDP-43 in the brain. By expressing mutant TDP-43 (M337V) in
Yin, Peng, Guo, Xiangyu, Yang, Weili, Yan, Sen, Yang, Su, Zhao, Ting, Sun, Qiang, Liu, Yunbo, Li, Shihua, Li, Xiao-Jiang   +9 more
openaire   +3 more sources

Interleukin-17F suppressed colon cancer by enhancing caspase 4 mediated pyroptosis of endothelial cells [PDF]

Scientific Reports
The combination of anti-angiogenic treatment and immunotherapy presents a promising strategy against colon cancer. Interleukin-17F (IL-17F) emerges as a critical immune cell cytokine expressed in colonic epithelial cells, demonstrating potential in ...
Ying Zhou, Mei Yang, Rishun Fu, Weihuang Liu, Zihan Cai, Hanyu Lin, Siheng Li, Chuanyu Zong, Yun Chen, Zan Tong   +9 more
doaj   +2 more sources

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease [PDF]

Alzheimer’s Research & Therapy
Alzheimer’s disease (AD) is the sixth leading cause of death in the USA. It is established that neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic decline of AD patients. Accumulating evidence suggests a critical role for
Kylene P. Daily, Asmaa Badr, Mostafa Eltobgy, Shady Estfanous, Owen Whitham, Michelle H. Tan, Cierra Carafice, Kathrin Krause, Andrew McNamara, Kaitlin Hamilton, Samuel Houle, Spandan Gupta, Gauruv A. Gupta, Shruthi Madhu, Julie Fitzgerald, Abbey A. Saadey, Brooke Laster, Pearlly Yan, Amy Webb, Xiaoli Zhang, Maciej Pietrzak, Olga N. Kokiko-Cochran, Hazem E. Ghoneim, Amal O. Amer   +23 more
doaj   +2 more sources

Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium [PDF]

Communications Biology
Intestinal epithelial-derived IL-18 is critical for homeostatic intestinal barrier function and is secreted through Gasdermin D (GSDMD) pores. Inflammasome activation is a prerequisite for both IL-18 maturation and GSDMD pore formation.
J. K. Bruce, L. Y. Li, Y. Tang, E. Forster, N. J. Winsor, P. Y. Bi, C. Krustev, S. Keely, J. E. Lee, J. R. Rohde, H. Y. Gaisano, D. J. Philpott, S. E. Girardin   +12 more
doaj   +2 more sources

Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages [PDF]

Cell Reports, 2019
Microbial infections can stimulate the assembly of inflammasomes, which activate caspase-1. The gastrointestinal pathogen enteropathogenic Escherichia coli (EPEC) causes localized actin polymerization in host cells. Actin polymerization requires the binding of the bacterial adhesin intimin to Tir, which is delivered to host cells via a type 3 secretion
Goddard, P, Sanchez Garrido, J, Slater, S, Kalyan, M, Ruano Gallego, D, Marchès, O, Fernández, LÁ, Frankel, G, Shenoy, A   +8 more
openaire   +6 more sources

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation [PDF]

Molecular & Cellular Proteomics, 2017
Gram-negative bacteria are associated with a wide spectrum of infectious diseases in humans. Inflammasomes are cytosolic protein complexes that are assembled when the cell encounters pathogens or other harmful agents.
Angus, Baker, Chakrabarti, Chen, Cypryk, Cypryk, Hagar, He, Hikita, Horiuchi, Hotamisligil, Kayagaki, Kaye, Lampinen, Lee, Lemaitre, Lietzén, Medzhitov, Meissner, Mohr, Mosoian, O'Connell, Ohman, Pirhonen, Poltorak, Pruenster, Qiu, Rabouille, Raposo, Rayamajhi, Romani, Saftig, Schroder, Shi, Storek, Szklarczyk, Vizcaíno, Vogl, Välimäki, Välimäki, Yang, Zanoni, Zhang, Zhu, Öhman   +44 more
core   +2 more sources

Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study

Journal of Indian Society of Periodontology
Background: Periodontitis and diabetes are chronic diseases where inflammation plays a central role, with each condition exacerbating the other. Pyroptosis, an inflammatory form of programmed cell death, is implicated in periodontitis and diabetes.
Lalitha Tanjore Arunachalam, Snophia Suresh, Vamsi Lavu, Shankarram Vedamanickam, John Ebinezer, Bhavishya Balachandran   +5 more
doaj   +2 more sources

Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

Nature Communications, 2018
Lipid A from some bacteria is sensed differently by humans and mice for the activation of the inflammasomes and inflammatory responses, but the mechanisms are not clear.
Brice Lagrange, Sacha Benaoudia, Pierre Wallet, Flora Magnotti, Angelina Provost, Fanny Michal, Amandine Martin, Flaviana Di Lorenzo, Bénédicte F. Py, Antonio Molinaro, Thomas Henry   +10 more
doaj   +2 more sources