Results 251 to 260 of about 335,290 (304)

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors. [PDF]

Bone Res
Krishnacoumar B, Stenzel M, Garibagaoglu H, Omata Y, Sworn RL, Hofmann T, Ipseiz N, Czubala MA, Steffen U, Maccataio A, Stoll C, Böhm C, Herrmann M, Uderhardt S, Jenkins RH, Taylor PR, Grüneboom A, Zaiss MM, Schett G, Krönke G, Scholtysek C.   +20 more
europepmc   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Targeting caspase-8/c-FLIP_L heterodimer in complex II promotes DL-mediated cell death. [PDF]

Front Cell Dev Biol
Hillert-Richter LK, König C, Ivanisenko NV, Reinhold D, Lavrik IN.   +4 more
europepmc   +1 more source

c-FLIP facilitates ZIKV infection by mediating caspase-8/3-dependent apoptosis. [PDF]

PLoS Pathog
Zhang S, Li N, Wu S, Xie T, Chen Q, Wu J, Zeng S, Zhu L, Bai S, Zha H, Tian W, Wu N, Zou X, Fang S, Luo C, Shi M, Sun C, Shu Y, Luo H.   +18 more
europepmc   +1 more source

Caspase-8-and Gasdermin D (GSDMD)-Dependent PANoptosis Participate in the Seasonal Atrophy of Scented Glands in Male Muskrats. [PDF]

Animals (Basel)
Tong X, Zhao X, Ma Y, Li H, Zhang J, Zhang Z, Hua S, Li B, Zhang W, Zhang Y, Bai S.   +10 more
europepmc   +1 more source

Helicobacter Pylori-induced BRD2 m⁶A modification sensitizes gastric cancer cells to chemotherapy by breaking FLIP/Caspase-8 homeostasis. [PDF]

Int J Biol Sci
Wang S, Xuan Z, Chen Z, Xu P, Fang L, Li Z, Zhang Y, Liu H, Wang L, Zhang D, Xu H, Yang L, Xu Z.   +12 more
europepmc   +1 more source

Genetically predicted Caspase 8 levels mediates the causal association between CD4+ T cell and breast cancer. [PDF]

Front Immunol
Chen Y, Zheng Z, Wang J, Huang X, Xie L.
europepmc   +1 more source

A CRISPR-HITI strategy approach to improve CHO cell viability by modifying the 3'UTR of Caspase 8 Associated Protein 2. [PDF]

Mol Biol Res Commun
Sorourian S, Behzad-Behbahani A, Forouzanfar M, Jafarinia M, Safari F.   +4 more
europepmc   +1 more source

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Caspase-8 for Outer Harmony

Science Signaling, 2009
Ablation of caspase-8 in keratinocytes activates proliferative and inflammatory responses in the epidermis.
Sollberger, Gabriel, Beer, Hans-Dietmar
openaire   +3 more sources