Results 131 to 140 of about 628,785 (360)
Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Epilepsy affects > 50 million people worldwide and is associated with a disproportionate burden of cognitive impairment. Emerging evidence suggests that neurodegenerative proteinopathies, particularly hyperphosphorylated tau (p‐tau) and amyloid‐β (Aβ), may contribute to cognitive dysfunction in people with epilepsy (PWE), even in the absence ...
Syeda Amrah Hashmi +7 more
wiley +1 more source
Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor [PDF]
, 2011 Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information ...
Tianhui Hu +8 more
core +1 more source
Open ChemistryBreast cancer (BC) continues to be a primary worldwide health concern despite the tremendous efforts made to deploy novel chemotherapeutic techniques for the treatment of BC. It is, therefore, essential to elucidate better plant-based compounds targeting
Pandey Pratibha +6 more
doaj +1 more source
Cell Death and Disease, 2019 Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients receiving high-dose propofol. High-dose propofol treatment with a prolonged duration can damage the immune system.
Lingbin Sun +7 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.An interstitium‐mimicking membrane combines three‐dimensional alveolar geometry, high pore interconnectivity, and mechanical compliance to overcome transport limitations of conventional lung‐on‐chip barriers. The resulting platform supports physiologic aerosol transport, quantitative analysis of cross‐barrier particle movement, and reveals divergent ...
Jae‐Won Choi +11 more
wiley +1 more source
Caspase-3/7 activity assay for the validation of NSC207895, vorinostat and belinostat. [PDF]
(A) Representative images of caspase-3/7 activity after NSC207895 treatment in RD cells. (B) Quantification of the percentage of apoptotic cells per field of view.
Eunmi Jang (17854725) +6 more
core +1 more source
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
Journal of Biological Chemistry, 1997 There is compelling evidence that members of the caspase (interleukin-1β converting enzyme/CED-3) family of cysteine proteases and the cytotoxic lymphocyte-derived serine protease granzyme B play essential roles in mammalian apoptosis.
N. Thornberry +11 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.A biomimetic aerogel conduit was engineered from a nanofiber of gelatin/poly(l‐lactic acid) doped with polypyrrole nanoparticles, integrated with tannic acid and Mg2+. This “electro‐ionic‐immune” strategy mimicked spinal cord properties, reduced calcium overload, inflammation, oxidative damage, promoted neural stem cell differentiation, suppressed ...
Qingxiang Liu +9 more
wiley +1 more source
Molecules, 2012 Apoptotic resistance is the main obstacle for treating cancer patients with chemotherapeutic drugs. Multidrug resistance (MDR) is often characterized by the expression of P-glycoprotein (P-gp), a 170-KD ATP-dependent drug efflux protein.
Li-Wu Fu +6 more
doaj +1 more source
Nature Immunology, 2009 The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18, as well as 'pyroptosis', a form of cell death induced by bacterial pathogens.
L. Franchi +3 more
semanticscholar +1 more source