Results 1 to 10 of about 24,421,742 (361)

Adipose tissue IL‐18 production is independent of caspase‐1 and caspase‐11 [PDF]

Immunity, Inflammation and Disease
Background Inflammation in adipose tissue, resulting from imbalanced caloric intake and energy expenditure, contributes to the metabolic dysregulation observed in obesity.
Luis Román‐Domínguez, Jonathan Salazar‐León, Karla F. Meza‐Sosa, Leonor Pérez‐Martínez, Gustavo Pedraza‐Alva   +4 more
doaj   +4 more sources

Caspase-1 activates gasdermin A in non-mammals. [PDF]

Elife, 2023
Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E. Caspase and granzyme proteases cleave the linker regions of and activate GSDMB, C, D, and E, but no endogenous activation pathways are yet known for GSDMA ...
Billman ZP, Kovacs SB, Wei B, Kang K, Cissé OH, Miao EA.   +5 more
europepmc   +5 more sources

Differential roles of caspase-1 and caspase-11 in infection and inflammation [PDF]

Scientific Reports, 2017
Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis.
Si Ming Man, Rajendra Karki, B. Briard, A. Burton, S. Gingras, S. Pelletier, T. Kanneganti   +6 more
semanticscholar   +5 more sources

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy. [PDF]

Journal of the American Society of Nephrology, 2016
Glomerular apoptosis may contribute to diabetic nephropathy (dNP), but the pathophysiologic relevance of this process remains obscure. Here, we administered two partially disjunct polycaspase inhibitors in 8-week-old diabetic (db/db) mice: M-920 ...
K. Shahzad, F. Bock, M. M. Al-Dabet, I. Gadi, S. Kohli, Sumra Nazir, Sanchita P. Ghosh, S. Ranjan, Hongjie Wang, T. Madhusudhan, P. Nawroth, B. Isermann   +11 more
semanticscholar   +3 more sources

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8. [PDF]

Journal of Molecular Biology, 2018
Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical ...
V. Sagulenko, N. Vitak, P. Vajjhala, J. Vince, K. Stacey   +4 more
semanticscholar   +5 more sources

Shenfu Injection Mediated NLRP3/Caspase 1 Through (R)-Norcoclaurinee Alleviates Sepsis-Induced Cognitive Dysfunction [PDF]

Journal of Inflammation Research
Xinqiang Liu,1,* Hongguang Ding,2,* Miner Chen,1,* Xusheng Li,2 Yan Xiao,1 Yongli Han,1 Hongke Zeng1 1Department of Intensive Care Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical ...
Liu X, Ding H, Chen M, Li X, Xiao Y, Han Y, Zeng H   +6 more
doaj   +2 more sources

Isoflavone Attenuates the Caspase-1 and Caspase-3 Level in Cell Model of Parkinsonism [PDF]

Behavioural Neurology, 2015
The study has investigated the effect of isoflavone attenuates the caspase-1 and caspase-3 level in cell model of Parkinsonism. The subjects were PC12 cells.
Jian-xin Xu, Hai-ping Song, Qing-Xia Bu, De-Peng Feng, Xiao-Fan Xu, Qian-Ru Sun, Xue-Li Li   +6 more
doaj   +3 more sources

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

Journal of Hematology & Oncology, 2017
Background It is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues indicated that caspase-1 can ...
Ya-feng Li, Gayani Nanayakkara, Yu Sun, Xinyuan Li, Luqiao Wang, Ramon Cueto, Ying Shao, Hangfei Fu, Candice Johnson, Jiali Cheng, Xiongwen Chen, Wenhui Hu, Jun Yu, Eric T. Choi, Hong Wang, Xiao-feng Yang   +15 more
doaj   +2 more sources

Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

Journal of Hematology & Oncology, 2016
Background Caspase-1 is present in the cytosol as an inactive zymogen and requires the protein complexes named “inflammasomes” for proteolytic activation.
Luqiao Wang, Hangfei Fu, Gayani Nanayakkara, Yafeng Li, Ying Shao, Candice Johnson, Jiali Cheng, William Y. Yang, Fan Yang, Muriel Lavallee, Yanjie Xu, Xiaoshu Cheng, Hang Xi, Jonathan Yi, Jun Yu, Eric T. Choi, Hong Wang, Xiaofeng Yang   +17 more
doaj   +2 more sources

Caspase-1 Deficiency Modulates Adipogenesis through Atg7-Mediated Autophagy: An Inflammatory-Independent Mechanism [PDF]

Biomolecules
Obesity stands as a significant risk factor for type 2 diabetes, hyperlipidemia, and cardiovascular diseases, intertwining increased inflammation and decreased adipogenesis with metabolic disorders.
Yumeng Wang, Gaojun Chen, Min Xu, Yewei Cui, Weijiong He, Hongxiang Zeng, Ting Zeng, Rui Cheng, Xi Li   +8 more
doaj   +2 more sources