Results 1 to 10 of about 24,258,002 (357)

Apoptosis in prostate carcinoma tissue: The role of caspase-3, caspase-1, and alkaline DNase activity [PDF]

Journal of Medical Biochemistry
Background: Prostate glandular tissue maintains a delicate balance between cellular proliferation and programmed cell death (apoptosis), ensuring the preservation of normal glandular architecture in healthy individuals.
Veljkovic Andrej, Hadzi-Djokic Jovan, Kocic Gordana, Li Xiaobo, Roumeliotis Stefanos, Sokolović Dušan, Klisic Aleksandra   +6 more
doaj   +2 more sources

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

Journal of Hematology & Oncology, 2017
Background It is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues indicated that caspase-1 can ...
Ya-feng Li, Gayani Nanayakkara, Yu Sun, Xinyuan Li, Luqiao Wang, Ramon Cueto, Ying Shao, Hangfei Fu, Candice Johnson, Jiali Cheng, Xiongwen Chen, Wenhui Hu, Jun Yu, Eric T. Choi, Hong Wang, Xiao-feng Yang   +15 more
doaj   +2 more sources

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

Nature Immunology, 2009
L. Franchi, T. Eigenbrod, Raúl Muñoz-Planillo, G. Núñez   +3 more
exaly   +2 more sources

Pyroptosis- What We Know and the Road Ahead! [PDF]

Journal of Clinical and Diagnostic Research, 2022
Pyroptosis, a type of cell death, initiated by proinflammatory signals, is classically associated with inflammation. It was thought to occur mainly in macrophages and leukocytes during inflammatory conditions and involves the activation of caspase 1 ...
Anitha Krishnan Pandarathodiyil, Srinivas Prasad Vijayan, Roopa S Rao, Anil Sukumaran   +3 more
doaj   +1 more source

Comparison of Transcriptome Responses between Sogatella furcifera Females That Acquired Southern Rice Black-Streaked Dwarf Virus and Not

Insects, 2022
The southern rice black-streaked dwarf virus (SRBSDV) is transmitted horizontally by Sogatella furcifera in a persistent, propagative manner. Exposure of S.
Dandan Liu, Zhengxi Li, Maolin Hou
doaj   +1 more source

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells

Cell Death Discovery, 2022
Histone deacetylase 11 (HDAC11), a sole member of the class IV HDAC subfamily, participates in various cardiovascular diseases. Recent evidence showed that pyroptosis was a form of inflammatory programmed cell death and is critical for atherosclerosis ...
Feng Yao, Zhen Jin, Zihan Zheng, Xiaohan Lv, Lingxuan Ren, Jianjun Yang, Danli Chen, Bo Wang, Wei Yang, Lifang Chen, Weirong Wang, Jianli Gu, R. Lin   +12 more
semanticscholar   +1 more source

Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death

Research, 2022
Inflammasomes are essential complexes of innate immune system, which form the first line of host defense against pathogens. Mounting evidence accumulates that inflammasome signaling is highly correlated with coronavirus disease 2019 (COVID-19).
Xiang Li, Peipei Zhang, Zhiyong Yin, Fei Xu, Zhang-Hua Yang, Jun Jin, Jing, Qu, Zhilong Liu, Hong Qi, Chen-Hui Yao, Jianwei Shuai   +11 more
semanticscholar   +1 more source

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer

International Journal on Biological Sciences, 2021
Cisplatin (DDP) was reported to improve pathological complete response (pCR) rates in triple-negative breast cancer (TNBC) patients, however, the molecular mechanism still remains largely unknown.
Honglin Yan, B. Luo, Xiaoyan Wu, F. Guan, Xinxin Yu, Lina Zhao, Xiaokang Ke, Juan Wu, Jingping Yuan   +8 more
semanticscholar   +1 more source

Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury

eLife, 2023
Potassium efflux via the two-pore K+ channel TWIK2 is a requisite step for the activation of NLRP3 inflammasome, however, it remains unclear how K+ efflux is activated in response to select cues.
Long Shuang Huang, Mohammad Anas, Jingsong Xu, Bisheng Zhou, Peter T Toth, Yamuna Krishnan, Anke Di, Asrar B Malik   +7 more
doaj   +1 more source

Inflammasome, the Constitutive Heterochromatin Machinery, and Replication of an Oncogenic Herpesvirus

Viruses, 2021
The success of long-term host–virus partnerships is predicated on the ability of the host to limit the destructive potential of the virus and the virus’s skill in manipulating its host to persist undetected yet replicate efficiently when needed.
Sumita Bhaduri-McIntosh, Michael T. McIntosh   +1 more
doaj   +1 more source