Results 11 to 20 of about 509,167 (309)

Reversine and herbal Xiang–Sha–Liu–Jun–Zi decoction ameliorate thioacetamide-induced hepatic injury by regulating the RelA/NF-κB/caspase signaling pathway

Open Life Sciences, 2020
This study investigated the anti-fibrotic effects of reversine and Chinese medicine Xiang–Sha–Liu–Jun–Zi decoction (XSLJZD) on thioacetamide (TAA)-induced hepatic injury.
Mai Zhen-Hao, Huang Yu, Huang Di, Huang Zi-Sheng, He Zhi-Xiang, Li Pei-Lin, Zhang Shuai, Weng Jie-Feng, Gu Wei-Li   +8 more
doaj   +1 more source

Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury

eLife, 2023
Potassium efflux via the two-pore K+ channel TWIK2 is a requisite step for the activation of NLRP3 inflammasome, however, it remains unclear how K+ efflux is activated in response to select cues.
Long Shuang Huang, Mohammad Anas, Jingsong Xu, Bisheng Zhou, Peter T Toth, Yamuna Krishnan, Anke Di, Asrar B Malik   +7 more
doaj   +1 more source

Caspase-8 Potentiates Triglyceride (TG)-Induced Cell Death of THP-1 Macrophages via a Positive Feedback Loop

Korean Journal of Clinical Laboratory Science, 2021
Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis.
Byung Chul Jung, Jaewon Lim, Sung Hoon Kim, Yoon Suk Kim   +3 more
doaj   +1 more source

Defusing inflammasomes. [PDF]

, 2018
In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation.
Sandstrom, Andrew, VANCE, Russell E.
core   +1 more source

Metalloporphyrins inactivate caspase-3 and -8 [PDF]

, 2005
Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in ...
Blumenthal, Signe B., Brandt, Birte, Höltje, Hans-Dieter, Höltje, Monika, Kiemer, Alexandra K., Seyfried, Stefan, Tiegs, Gisa, Vollmar, Angelika M., Zahler, Stefan   +8 more
core   +1 more source

Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]

, 2009
The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele, De Martino, Luisa, Di Stefano, Carla, Fiorito, Filomena, Indelicato, Manuela, Marfe, Gabriella, Pucci, Bruna, Russo, Matteo A., Tafani, Marco   +8 more
core   +1 more source

Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria

Frontiers in Immunology, 2022
Inflammatory caspases detect cytosol-invasive Gram-negative bacteria by monitoring for the presence of LPS in the cytosol. This should provide defense against the cytosol-invasive Burkholderia and Shigella species by lysing the infected cell via ...
Carissa K. Harvest, Carissa K. Harvest, Carissa K. Harvest, Carissa K. Harvest, Edward A. Miao, Edward A. Miao, Edward A. Miao   +6 more
doaj   +1 more source

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]

, 2017
The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke, Demon, Dieter, Gonçalves, Amanda, Hochepied, Tino, Kanneganti, Thirumala-Devi, Krautwald, Stefan, Lamkanfi, Mohamed, Matusiak, Magdalena, Moraes de Vasconcelos, Nathalia, Van Gorp, Hanne, Van Hauwermeiren, Filip, Van Opdenbosch, Nina, Vande Walle, Lieselotte, Verdonckt, Maarten, Viana Saavedra, Pedro Henrique   +14 more
core   +2 more sources

Peroxynitrite/PKR Axis Modulates the NLRP3 Inflammasome of Cardiac Fibroblasts

Frontiers in Immunology, 2020
Sepsis/endotoxemia activates the NLRP3 inflammasome of macrophages leading to the maturation and release of IL-1β, an important mediator of the inflammatory response. Reactive oxygen species have been implicated in NLRP3 inflammasome activation. Further,
Ting Lan, Ting Lan, Ting Lan, Aibin Tao, Aibin Tao, Xuemei Xu, Xuemei Xu, Peter Kvietys, Tao Rui, Tao Rui, Tao Rui, Tao Rui   +11 more
doaj   +1 more source

Increased expression of caspase 1 during active phase of connective tissue disease [PDF]

PeerJ, 2019
Key factors of pyroptosis play an important role in the inflammatory response to connective tissue disease (CTD). However, information on active and stable stages of CTD is scarce.
Rentian Cai, Qiongqiong Wang, Gongmin Zhu, Liying Zhu, Zhen Tao   +4 more
doaj   +2 more sources