Results 11 to 20 of about 24,421,742 (361)

Pyroptosis- What We Know and the Road Ahead! [PDF]

Journal of Clinical and Diagnostic Research, 2022
Pyroptosis, a type of cell death, initiated by proinflammatory signals, is classically associated with inflammation. It was thought to occur mainly in macrophages and leukocytes during inflammatory conditions and involves the activation of caspase 1 ...
Anitha Krishnan Pandarathodiyil, Srinivas Prasad Vijayan, Roopa S Rao, Anil Sukumaran   +3 more
doaj   +1 more source

Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death

Research, 2022
Inflammasomes are essential complexes of innate immune system, which form the first line of host defense against pathogens. Mounting evidence accumulates that inflammasome signaling is highly correlated with coronavirus disease 2019 (COVID-19).
Xiang Li, Peipei Zhang, Zhiyong Yin, Fei Xu, Zhang-Hua Yang, Jun Jin, Jing, Qu, Zhilong Liu, Hong Qi, Chen-Hui Yao, Jianwei Shuai   +11 more
semanticscholar   +1 more source

A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages

Cells, 2023
Inflammation and mitochondrial-dependent oxidative stress are interrelated processes implicated in multiple neuroinflammatory disorders, including Alzheimer’s disease (AD) and depression.
Simmie L. Foster, Abigail J. Dutton, Adina Yerzhan, Lindsay B. March, Katherine Barry, Corey R. Seehus, Xudong Huang, Sebastien Talbot, Clifford J. Woolf   +8 more
doaj   +1 more source

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer

International Journal on Biological Sciences, 2021
Cisplatin (DDP) was reported to improve pathological complete response (pCR) rates in triple-negative breast cancer (TNBC) patients, however, the molecular mechanism still remains largely unknown.
Honglin Yan, B. Luo, Xiaoyan Wu, F. Guan, Xinxin Yu, Lina Zhao, Xiaokang Ke, Juan Wu, Jingping Yuan   +8 more
semanticscholar   +1 more source

Comparison of Transcriptome Responses between Sogatella furcifera Females That Acquired Southern Rice Black-Streaked Dwarf Virus and Not

Insects, 2022
The southern rice black-streaked dwarf virus (SRBSDV) is transmitted horizontally by Sogatella furcifera in a persistent, propagative manner. Exposure of S.
Dandan Liu, Zhengxi Li, Maolin Hou
doaj   +1 more source

Caspase-1: The inflammasome and beyond [PDF]

Innate Immunity, 2013
Caspase-1 plays a fundamental role in innate immunity and in several important inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β and proIL-18. Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous and endogenous stressors. More recently, pyroptosis,
Sollberger, Gabriel, Strittmatter, Gerhard E, Garstkiewicz, Martha, Sand, Jennifer, Beer, Hans-Dietmar   +4 more
openaire   +3 more sources

Acute Circadian Disruption Due to Constant Light Promotes Caspase 1 Activation in the Mouse Hippocampus

Cells, 2023
In mammals, the circadian system controls various physiological processes to maintain metabolism, behavior, and immune function during a daily 24 h cycle.
Pikria Ketelauri, Katerina Scharov, Charlotte von Gall, Sonja Johann   +3 more
doaj   +1 more source

An Allosteric Circuit in Caspase-1 [PDF]

Journal of Molecular Biology, 2008
Structural studies of caspase-1 reveal that the dimeric thiol protease can exist in two states: in an on-state, when the active site is occupied, or in an off-state, when the active site is empty or when the enzyme is bound by a synthetic allosteric ligand at the dimer interface approximately 15 A from the active site.
Debajyoti Datta, Justin Scheer, Michael J. Romanowski, James A. Wells   +3 more
openaire   +3 more sources

Caspase-1 and Caspase-8 Cleave and Inactivate Cellular Parkin [PDF]

Journal of Biological Chemistry, 2003
Lesions in the parkin gene cause early onset Parkinson's disease by a loss of dopaminergic neurons, thus demonstrating a vital role for parkin in the survival of these neurons. Parkin is inactivated by caspase cleavage, and the major cleavage site is after Asp126.
Kahns, Søren, Kalai, Michaël, Jakobsen, Lene Diness, Clark, Brian F. C., Vandenabeele, Peter, Jensen, Poul Henning   +5 more
openaire   +5 more sources

Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer

Cancers, 2020
Trillium tschonoskii Maxim (TTM), a traditional Chinese medicine, has been demonstrated to have a potent anti-tumor effect. Recently, polyphyllin VI (PPVI), a main saponin isolated from TTM, was reported by us to significantly suppress the proliferation ...
Jin-Feng Teng, Q. Mei, Xiaogang Zhou, Yong Tang, R. Xiong, Wenqiao Qiu, Rong Pan, B. Law, V. Wong, Chong-Lin Yu, Han-an Long, Xiu-Li Xiao, Feng Zhang, Jianming Wu, Da-Lian Qin, Anguo Wu   +15 more
semanticscholar   +1 more source