Results 11 to 20 of about 24,233,392 (378)
Differential roles of caspase-1 and caspase-11 in infection and inflammation [PDF]
Scientific Reports, 2017 Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis.
Si Ming Man +6 more
semanticscholar +5 more sources
Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy. [PDF]
Journal of the American Society of Nephrology, 2016 Glomerular apoptosis may contribute to diabetic nephropathy (dNP), but the pathophysiologic relevance of this process remains obscure. Here, we administered two partially disjunct polycaspase inhibitors in 8-week-old diabetic (db/db) mice: M-920 ...
K. Shahzad +11 more
semanticscholar +3 more sources
Isoflavone Attenuates the Caspase-1 and Caspase-3 Level in Cell Model of Parkinsonism [PDF]
Behavioural Neurology, 2015 The study has investigated the effect of isoflavone attenuates the caspase-1 and caspase-3 level in cell model of Parkinsonism. The subjects were PC12 cells.
Jian-xin Xu +6 more
doaj +3 more sources
Research, 2022 Inflammasomes are essential complexes of innate immune system, which form the first line of host defense against pathogens. Mounting evidence accumulates that inflammasome signaling is highly correlated with coronavirus disease 2019 (COVID-19).
Xiang Li +11 more
semanticscholar +1 more source
International Journal on Biological Sciences, 2021 Cisplatin (DDP) was reported to improve pathological complete response (pCR) rates in triple-negative breast cancer (TNBC) patients, however, the molecular mechanism still remains largely unknown.
Honglin Yan +8 more
semanticscholar +1 more source
Caspase-1: The inflammasome and beyond [PDF]
Innate Immunity, 2013 Caspase-1 plays a fundamental role in innate immunity and in several important inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β and proIL-18. Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous and endogenous stressors. More recently, pyroptosis,
Sollberger, Gabriel +4 more
openaire +4 more sources
Insects, 2022 The southern rice black-streaked dwarf virus (SRBSDV) is transmitted horizontally by Sogatella furcifera in a persistent, propagative manner. Exposure of S.
Dandan Liu, Zhengxi Li, Maolin Hou
doaj +1 more source
An Allosteric Circuit in Caspase-1 [PDF]
Journal of Molecular Biology, 2008 Structural studies of caspase-1 reveal that the dimeric thiol protease can exist in two states: in an on-state, when the active site is occupied, or in an off-state, when the active site is empty or when the enzyme is bound by a synthetic allosteric ligand at the dimer interface approximately 15 A from the active site.
Debajyoti Datta +3 more
openaire +3 more sources
eLife, 2023 Potassium efflux via the two-pore K+ channel TWIK2 is a requisite step for the activation of NLRP3 inflammasome, however, it remains unclear how K+ efflux is activated in response to select cues.
Long Shuang Huang +7 more
doaj +1 more source
Viruses, 2021 The success of long-term host–virus partnerships is predicated on the ability of the host to limit the destructive potential of the virus and the virus’s skill in manipulating its host to persist undetected yet replicate efficiently when needed.
Sumita Bhaduri-McIntosh +1 more
doaj +1 more source