Results 11 to 20 of about 24,258,002 (357)
Differential roles of caspase-1 and caspase-11 in infection and inflammation [PDF]
Scientific Reports, 2017 Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis.
Si Ming Man +6 more
semanticscholar +5 more sources
Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy. [PDF]
Journal of the American Society of Nephrology, 2016 Glomerular apoptosis may contribute to diabetic nephropathy (dNP), but the pathophysiologic relevance of this process remains obscure. Here, we administered two partially disjunct polycaspase inhibitors in 8-week-old diabetic (db/db) mice: M-920 ...
K. Shahzad +11 more
semanticscholar +3 more sources
Adipose tissue IL‐18 production is independent of caspase‐1 and caspase‐11
Immunity, Inflammation and DiseaseBackground Inflammation in adipose tissue, resulting from imbalanced caloric intake and energy expenditure, contributes to the metabolic dysregulation observed in obesity.
Luis Román‐Domínguez +4 more
doaj +3 more sources
Isoflavone Attenuates the Caspase-1 and Caspase-3 Level in Cell Model of Parkinsonism [PDF]
Behavioural Neurology, 2015 The study has investigated the effect of isoflavone attenuates the caspase-1 and caspase-3 level in cell model of Parkinsonism. The subjects were PC12 cells.
Jian-xin Xu +6 more
doaj +3 more sources
Caspase-1: The inflammasome and beyond [PDF]
Innate Immunity, 2013 Caspase-1 plays a fundamental role in innate immunity and in several important inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β and proIL-18. Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous and endogenous stressors. More recently, pyroptosis,
Sollberger, Gabriel +4 more
openaire +4 more sources
A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages
Cells, 2023 Inflammation and mitochondrial-dependent oxidative stress are interrelated processes implicated in multiple neuroinflammatory disorders, including Alzheimer’s disease (AD) and depression.
Simmie L. Foster +8 more
doaj +1 more source
An Allosteric Circuit in Caspase-1 [PDF]
Journal of Molecular Biology, 2008 Structural studies of caspase-1 reveal that the dimeric thiol protease can exist in two states: in an on-state, when the active site is occupied, or in an off-state, when the active site is empty or when the enzyme is bound by a synthetic allosteric ligand at the dimer interface approximately 15 A from the active site.
Debajyoti Datta +3 more
openaire +3 more sources
Pathogens, 2020 Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI.
Alexander M. Fagenson +13 more
doaj +1 more source
Journal of Integrative Agriculture, 2023 Oomycete, particularly Phytophthora species, causes the most devastating crop diseases, such as potato late blight, and threatens the sustainable crop production worldwide. Our previous studies identified Resistance to Phytophthora parasitica 1 (RTP1) as
Xian-xian GAO +6 more
doaj +1 more source
Caspase-1 and Caspase-8 Cleave and Inactivate Cellular Parkin [PDF]
Journal of Biological Chemistry, 2003 Lesions in the parkin gene cause early onset Parkinson's disease by a loss of dopaminergic neurons, thus demonstrating a vital role for parkin in the survival of these neurons. Parkin is inactivated by caspase cleavage, and the major cleavage site is after Asp126.
Kahns, Søren +5 more
openaire +5 more sources