Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival [PDF]
Apoptosis, 2016 Impaired apoptosis is one of the hallmarks of cancer. Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis.
X. Pu +6 more
semanticscholar +8 more sources
Metalloporphyrins inactivate caspase-3 and -8 [PDF]
The FASEB Journal, 2005 Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in ...
Blumenthal, Signe B. +8 more
core +6 more sources
Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy. [PDF]
Journal of the American Society of Nephrology, 2016 Glomerular apoptosis may contribute to diabetic nephropathy (dNP), but the pathophysiologic relevance of this process remains obscure. Here, we administered two partially disjunct polycaspase inhibitors in 8-week-old diabetic (db/db) mice: M-920 ...
K. Shahzad +11 more
semanticscholar +3 more sources
Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013 Cleavage of Rho associated Coiled Coil kinase I (ROCK I) by caspase-3 contributes to membrane blebbing. Whether caspase-3 and ROCK I also play a role in the release of membrane vesicles is unknown.
Afink, G.B. +8 more
core +4 more sources
Emerging roles of caspase-3 in apoptosis [PDF]
Cell Death & Differentiation, 1999 Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death protease, catalyzing the specific cleavage of many key cellular proteins. However, the specific requirements of this (or any other) caspase in apoptosis have remained largely unknown until now. Pathways to caspase-3 activation have
A. Porter, R. Jänicke
semanticscholar +4 more sources
The prodomain of caspase-3 regulates its own removal and caspase activation [PDF]
Cell Death Discovery, 2019 Caspase-3 is a cysteine–aspartic acid protease that cleaves cellular targets and executes cell death. Our current understanding is caspase-3 is activated by the cleavage of the interdomain linker and then subsequent cleavage of the N-terminal prodomain ...
Katelyn G. Ponder, L. Boise
semanticscholar +4 more sources
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death [PDF]
Nature Communications, 2017 Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Corey Rogers +5 more
semanticscholar +3 more sources
Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis [PDF]
Cell Death and Differentiation, 2016 Programmed cell death (PCD) is used by plants for development and survival to biotic and abiotic stresses. The role of caspases in PCD is well established in animal cells.
Yuan Ge +10 more
semanticscholar +7 more sources
Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8. [PDF]
Journal of Molecular Biology, 2018 Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical ...
V. Sagulenko +4 more
semanticscholar +5 more sources
Caspase-3 Colorimetric Assay [PDF]
BioTechniques, 2002 Lizhi Zeng, Larry D. Smith
doaj +3 more sources