Results 241 to 250 of about 332,821 (272)

Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome

Nature, 2023
The canonical (caspase-1) and noncanonical (comprising caspases 4, 5 and 11; hereafter, caspase-4/5/11) inflammasomes both cleave gasdermin D (GSDMD) to induce pyroptosis1,2. Whereas caspase-1 processes IL-1β and IL-18 for maturation3-6, no cytokine target has been firmly established for lipopolysaccharide-activated caspase-4/5/117-9. Here we show that
Xuyan Shi, Qichao Sun, Yanjie Hou, Huan Zeng, Yong Cao, Mengqiu Dong, Jingjin Ding, Feng Shao   +7 more
openaire   +2 more sources

Caspase-4 Activation and Recruitment to Intracellular Gram-Negative Bacteria

2023
The non-canonical inflammasome pathway functions as the primary cytosolic innate immune detection mechanism for Gram-negative bacterial lipopolysaccharide (LPS) in human and mouse cells and controls the proteolytic activation of the cell death executor gasdermin D (GSDMD). The main effectors of this pathways are the inflammatory proteases caspase-11 in
Marisa, Dilucca, Petr, Broz
openaire   +2 more sources

Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases [PDF]

Cell Death and Differentiation, 1997
Proteases of the caspase family are implicated in mammalian apoptosis and constitute a protease cascade. We characterized caspase-4 (TX/ICH-2/ICErelII) and caspase-5 (ICErelIII/TY), which are most closely related to caspase-1 (ICE) among the caspase family.
Shinji Kamada, Yoshihide Tsujimoto, Yoshihide Tsujimoto   +2 more
exaly   +3 more sources

Both dimerization and interdomain processing are essential for caspase-4 activation

Biochemical and Biophysical Research Communications, 2007
A subgroup of caspase family of inflammatory caspases (-1, -4, -5, -11, and -12) play important role during cytokine maturation and inflammation but their regulation is not well understood as much as the initiator and effector caspases. Here, the biochemical mechanism of caspase-4 activation is elucidated.
Pratap, Karki, Giri Raj, Dahal, Il-Seon, Park   +2 more
openaire   +2 more sources

Phillyrin ameliorates sepsis via targeting microRNA-203a-mediated caspase-4/caspase-11/caspase-B downregulation to suppress endothelial pyroptosis

Phytomedicine
Sepsis, driven by dysregulated host inflammation, remains a leading cause of global mortality and lacks sufficiently effective therapies. Phillyrin (PHN), a lignan glycoside from Forsythia suspensa (Thunb.) Vahl (Oleaceae), exhibits anti-inflammatory and antimicrobial properties.
Xiangjun Zhou, Guangli Yang, Weifu Tan, Hongyan Ding, Wujuan Zheng, Yong Liu, Liyi Zou, Xiaohua Su, Linzhong Yu, Wei Li, Liling Yang   +10 more
openaire   +2 more sources

Citrus-caspase-4–serotonin axis: Aurantii Fructus rapidly reverses chronic-stress-induced despair via suppression of hippocampal caspase-4

Journal of Ethnopharmacology
The citrus-derived flavonoid-rich fraction Aurantii Fructus (AF) has been traditionally used in East Asian folk medicine to relieve mood-related complaints, yet its antidepressant profile and mechanism remain ill-defined.To evaluate the antidepressant-like activity of AF in a chronic unpredictable mild stress (CUMS) mouse model and to identify the ...
Chao, Lu, Ziwei, Gao, Zixuan, Wei, Yaping, Zhu, Mengqi, Shao, Yiran, Jiang, Lei, Wu   +6 more
openaire   +2 more sources

Arsenic Trioxide Induces Apoptosis in Molt-4 Cell Lines: Caspase 8-Dependent and Caspase 3-Independent.

Blood, 2004
Abstract Arsenic Trioxide (As2O3) has been used successfully in the treatment of patients with relapsed or refractory acute promyelocytic leukemia (APL) without severe marrow suppression. Currently, the action of As2O3 on many other hematopoietic malignancies is under investigation.
Wenbin Qian, Wanmao Ni, Junqing Liu
openaire   +1 more source

[Apoptosis and expression of Caspase 3 and Caspase 4 in neurocytes of refractory human temporal lobe epilepsy].

Zhonghua yi xue za zhi, 2017
To study apoptosis and expression of Caspase 3 and Caspase 4 in temporal lobe neurocytes of refractory human temporal lobe epilepsy (TLE).The temporal tissue samples were obtained from 30 cases of refractory TLE (TLE group) and 10 cases of brain trauma (contrast group) between January 1993 and May 2008.
R T, Lin, R R, Cai, P F, Zhang, Y X, Lin
openaire   +1 more source

Caspase-4 and Caspase-5

2013
Junjun Gao, James A. Wells
openaire   +1 more source

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

Cell, 2020
Min Zheng, Rajendra Karki
exaly