Results 231 to 240 of about 170,565 (294)

CASVM: web server for SVM-based prediction of caspase substrates cleavage sites

, 2007
Lawrence JK Wee, Tin Wee Tan, Shoba Ranganathan   +2 more
openalex   +2 more sources

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Silibinin Triggers Mitochondrial Apoptosis and Declines Clonogenic Potential in Detroit 562 Human Pharyngeal Carcinoma Cells. [PDF]

Medicina (Kaunas)
Talpos S, Chioran D, Alexandru GC, Dinu Ș, Coricovac ED, Smeu A, Ali DH, Szuhanek C, Popa M.   +8 more
europepmc   +1 more source

Distinct optical and kinetic responses from E/Z isomers of caspase probes with aggregation-induced emission characteristics

, 2014
Jing Liang, Haibin Shi, Ryan T. K. Kwok, Meng Gao, Youyong Yuan, Wen‐Hua Zhang, Ben Zhong Tang, Bin Liu   +7 more
openalex   +2 more sources

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Proteomics analysis reveals progesterone receptor induced mitochondria-mediated apoptosis in breast cancer cells. [PDF]

Sci Rep
Woo QY, Lau PK, Lee BTK, Bajalovic N, Lee SH, Leong KS, Pow KY, Hanan S, Meng W, Lai SK, Lin VC.   +10 more
europepmc   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Glycochenodeoxycholate-Induced Apoptosis Is Not Reduced by Augmenter of Liver Regeneration in the Human Hepatoma Cell Line HuH-7 [PDF]

, 2010
Denk, Gerald Ulrich, Pusl, Thomas, Rust, Christian, Thasler, Wolfgang H., Vennegeerts, Timo, Wimmer, Ralf   +5 more
core   +1 more source

Decision letter: CasExpress reveals widespread and diverse patterns of cell survival of caspase-3 activation during development in vivo

, 2015

openalex   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source