Results 81 to 90 of about 160,266 (354)

TRAIL Activates a Caspase 9/7-Dependent Pathway in Caspase 8/10-Defective SK-N-SH Neuroblastoma Cells with Two Functional End Points: Induction of Apoptosis and PGE2 Release

open access: yesNeoplasia: An International Journal for Oncology Research, 2003
Most neuroblastoma cell lines do not express apical caspases 8 and 10, which play a key role in mediating tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity in a variety of malignant cell types.
Giorgio Zauli   +6 more
doaj   +1 more source

Novel Apoptotic Mediators Identified by Conservation of Vertebrate Caspase Targets

open access: yesBiomolecules, 2020
Caspases are proteases conserved throughout Metazoans and responsible for initiating and executing the apoptotic program. Currently, there are over 1800 known apoptotic caspase substrates, many of them known regulators of cell proliferation and death ...
Nina Gubina   +3 more
doaj   +1 more source

In Vitro Assessment of the Synergistic Effect of Aspirin and 5-Fluorouracil in Colorectal Adenocarcinoma Cells

open access: yesCurrent Oncology, 2023
Although remarkable progress has been made, colorectal cancer remains a significant global health issue. One of the most challenging aspects of cancer treatment is the resistance of tumor cells to classical chemotherapy.
Monica Susan   +6 more
doaj   +1 more source

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 [PDF]

open access: yes, 2014
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ‘accidental cell death’ (ACD).
A Ciechanover   +438 more
core   +15 more sources

Caspase substrates [PDF]

open access: yesCell Death & Differentiation, 2006
The relatively common occurrence of sequences within proteins that match the consensus substrate specificity of caspases in intracellular proteins suggests a multitude of substrates in vivo - somewhere in the order of several hundred in humans alone. Indeed, the list of proteins that are reported to be cleaved by caspases in vitro proliferates rapidly.
J C, Timmer, G S, Salvesen
openaire   +2 more sources

Immunohistochemical Aspects of Cell Death in Diabetic Nephropathy

open access: yesRomanian Journal of Internal Medicine, 2016
Introduction. Diabetes Mellitus causes ultrastructural changes triggered by partially clarified cellular mechanisms. Since cell death is an important mechanism in the appearance and progression of diabetic nephropathy, we studied alteration of several ...
Bălăşescu Elena   +5 more
doaj   +1 more source

Microglia: Agents of the CNS Pro-Inflammatory Response

open access: yesCells, 2020
The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. Though the research of microglia spans over a century, the last two decades have increased our understanding ...
José A. Rodríguez-Gómez   +9 more
doaj   +1 more source

Steady state and (bi-) stability evaluation of simple protease signalling networks [PDF]

open access: yes, 2007
Signal transduction networks are complex, as are their mathematical models. Gaining a deeper understanding requires a system analysis. Important aspects are the number, location and stability of steady states.
Allgöwer, F.   +4 more
core   +2 more sources

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

open access: yesFEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang   +5 more
wiley   +1 more source

Anticancer and Antibacterial Activity Studies of Gold(I)-Alkynyl Chromones

open access: yesMolecules, 2015
Three gold(I) complexes of alkynyl chromones were synthesized and characterized. The single-crystal X-ray structure analysis of a dinuclear compound and of a flavone derivative exhibit a typical d10 gold(I)-alkynyl linear arrangement.
Paweł Hikisz   +8 more
doaj   +1 more source

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