Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window [PDF]
Frontiers in Neural Circuits, 2023 Phrenic Motor Column (PMC) neurons are a specialized subset of motor neurons (MNs) that provide the only motor innervation to the diaphragm muscle and are therefore essential for survival.
Alicia N. Vagnozzi +6 more
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LY6/PLAUR domain containing 3 (LYPD3) maintains melanoma cell stemness and mediates an immunosuppressive microenvironment [PDF]
Biology Direct, 2023 Background Malignant melanoma is a highly heterogeneous skin cancer with the highest mortality rate among dermatological cancers. Catenins form functional networks in the nucleus to regulate gene expression and determine cell fate.
Yi-dou Hu +7 more
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p120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron development in vitro [PDF]
Frontiers in Cellular Neuroscience, 2023 Dendritic arborization is essential for proper neuronal connectivity and function. Conversely, abnormal dendrite morphology is associated with several neurological pathologies like Alzheimer’s disease and schizophrenia.
Maxsam S. Donta +9 more
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Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment [PDF]
Frontiers in Cell and Developmental Biology, 2023 Cadherin-catenin complexes are integral components of the adherens junctions crucial for cell-cell adhesion and tissue homeostasis. Dysregulation of these complexes is linked to cancer development via alteration of cell-autonomous oncogenic signaling ...
Wan-Hsin Lin +2 more
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Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity [PDF]
Journal of Lipid Research, 2015 Sphingolipids (SLs) are relevant lipid components of eukaryotic cells. Besides regulating various cellular processes, SLs provide the structural framework for plasma membrane organization.
Nicolás Octavio Favale +4 more
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Actin-dependent α-catenin oligomerization contributes to adherens junction assembly [PDF]
Nature CommunicationsClassic cadherins, specifically E-cadherin in most epithelial cells, are transmembrane adhesion receptors, whose intracellular region interacts with proteins, termed catenins, forming the cadherin-catenin complex (CCC).
Regina B. Troyanovsky +2 more
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A transphyletic study of metazoan β-catenin protein complexes [PDF]
Zoological LettersBeta-catenin is essential for diverse biological processes, such as body axis determination and cell differentiation, during metazoan embryonic development.
Ivan Mbogo +9 more
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Computational modeling of the interplay between cadherin-mediated cell adhesion and Wnt signaling pathway. [PDF]
PLoS ONE, 2014 Wnt signaling and cadherin-mediated adhesion have been implicated in both processes of embryonic development and the progression of carcinomas. Recent experimental studies revealed that Wnt signaling and cadherin-mediated cell adhesion have close ...
Jiawen Chen, Zhong-Ru Xie, Yinghao Wu
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Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases
Frontiers in Cell and Developmental Biology, 2022 The function and structure of the mammalian epithelial cell layer is maintained by distinct intercellular adhesion complexes including adherens junctions (AJs), tight junctions, and desmosomes.
Lindyann R. Lessey +3 more
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Exchange of catenins in cadherin–catenin complex [PDF]
Oncogene, 2003 beta-Catenin is an intracellular multifunctional protein. In complex with the transmembrane adhesive receptor E-cadherin, it becomes plasma membrane-associated and mediates intercellular adhesion. A cytosolic pool of beta-catenin interacts with DNA-binding proteins and participates in signal transduction. To reveal the possible cross-talk between these
Klingelhöfer, Jörg +3 more
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