Results 21 to 30 of about 10,779 (272)
Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. [PDF]
, 2016 1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family ...
Bikle, Daniel D +4 more
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Folia Histochemica et Cytobiologica, 2010 The E-cadherin-catenin complex plays an important role in the process of cell adhesion. Its dysfunction is associated with a decrease in cell differentiation and with increased invasiveness and metastasis.
Marek Ustymowicz +4 more
doaj +1 more source
Journal of the American Society of Nephrology, 2012 Wnt/ β -catenin signaling plays a significant role during kidney development and maturation.[1][1][][2]–[3][3] β -Catenin, the canonical Wnt signal transducer, is involved in nephron induction[4][4],[5][5] and branching morphogenesis.[1][1],[6][6] Importantly, β -catenin modulation is ...
openaire +2 more sources
World Journal of Surgical Oncology, 2008 Background The E-cadherin catenin system acts as an invasion suppressor of epithelial malignancies. However, it is debatable whether expression of E-cadherin or catenins is a useful prognostic marker in invasive breast cancer.
Mansel Robert E +3 more
doaj +1 more source
Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin [PDF]
, 2010 Background: Despite the well-documented association between loss of E-cadherin and carcinogenesis, as well as the link between restoration of its expression and suppression of proliferation in carcinoma cells, the ability of E-cadherin to modulate growth-
Dawn C. Walker +4 more
core +4 more sources
Regulation of classical cadherin membrane expression and F-actin assembly by alpha-catenins, during Xenopus embryogenesis. [PDF]
PLoS ONE, 2012 Alpha (α)-E-catenin is a component of the cadherin complex, and has long been thought to provide a link between cell surface cadherins and the actin skeleton.
Sumeda Nandadasa +4 more
doaj +1 more source
Tyrosine phosphatase activity is restricted by basic charge substituting mutation of substrates
Scientific Reports, 2022 Phosphorylation controls important cellular signals and its dysregulation leads to disease. While most phospho-regulation studies are focused on kinases, phosphatases are comparatively overlooked. Combining peptide arrays with SAMDI mass spectrometry, we
Che-Fan Huang +2 more
doaj +1 more source
Acta Cirúrgica Brasileira, 2021 Purpose: To evaluate the effects of sucralfate enemas in tissue contents of E-cadherin and ?-catenin in an experimental diversion colitis. Methods: Thirty-six male Wistar rats were submitted to a proximal colostomy and a distal mucous fistula. They were
Daniela Tiemi Sato +6 more
doaj +1 more source
Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
core +2 more sources
N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons [PDF]
, 2009 Vertebrate cranial sensory ganglia have a dual origin from the neural crest and ectodermal placodes. In the largest of these, the trigeminal ganglion, Slit1-Robo2 signaling is essential for proper ganglion assembly.
Bronner-Fraser, Marianne +1 more
core +2 more sources