Results 1 to 10 of about 16,157 (149)

Colonic epithelial cathelicidin (LL‐37) expression intensity is associated with progression of colorectal cancer and presence of CD8+ T cell infiltrate [PDF]

The Journal of Pathology: Clinical Research, 2021
Colorectal cancer (CRC) remains a leading cause of cancer mortality. Here, we define the colonic epithelial expression of cathelicidin (LL‐37) in CRC. Cathelicidin exerts pleotropic effects including anti‐microbial and immunoregulatory functions. Genetic
Ross J Porter, Graeme I Murray, Abdo Alnabulsi, Matthew P Humphries, Jacqueline A James, Manuel Salto‐Tellez, Stephanie G Craig, Ji M Wang, Teizo Yoshimura, Mairi H McLean   +9 more
doaj   +10 more sources

Antifungal Activity of Human Cathelicidin LL-37, a Membrane Disrupting Peptide, by Triggering Oxidative Stress and Cell Cycle Arrest in Candida auris [PDF]

Journal of Fungi, 2022
Candida auris, an evolving multidrug-resistant pathogenic yeast, is known for causing severe invasive infections associated with high mortality rates in hospitalized individuals. Distinct from other Candida species, C.
Irfan A. Rather, Jamal S. M. Sabir, Amer H. Asseri, Sajad Ali   +3 more
doaj   +2 more sources

Epithelial-Immune Cell Crosstalk Determines the Activation of Immune Cells In Vitro by the Human Cathelicidin LL-37 at Low Physiological Concentrations [PDF]

Biomolecules, 2023
The only human cathelicidin, LL-37, is a host defense antimicrobial peptide with antimicrobial activities against protozoans, fungi, Gram(+) and Gram(−) bacteria, and enveloped viruses.
Ivan V. Bogdanov, Maria A. Streltsova, Elena I. Kovalenko, Alexander M. Sapozhnikov, Pavel V. Panteleev, Tatiana V. Ovchinnikova   +5 more
doaj   +2 more sources

Cathelicidin LL-37 promotes EMT, migration and metastasis of hepatocellular carcinoma cells in vitro and mouse model [PDF]

Cell Adhesion & Migration, 2023
The effect of cathelicidin hCAP18/LL-37 in hepatocellular carcinoma (HCC) metastasis remains unclear. Here, we confirmed that LL-37 expression enhanced endothelial-mesenchymal transition (EMT), migration and invasion in HCC cells.
Huidan Zhang, Xueli Yuan, Yaxin Yang, Yangke Wanyan, Liping Tao, Yuqing Chen   +5 more
doaj   +2 more sources

Cathelicidin LL-37: A new important molecule in the pathophysiology of systemic lupus erythematosus [PDF]

Journal of Translational Autoimmunity, 2020
Cathelicidin LL-37 is an antimicrobial peptide that is synthesized by epithelial cells, neutrophils, or lymphocytes and act as an essential defense mechanism against bacterial, viral, or fungi infection of eukaryotic organisms.
Alejandro Moreno-Angarita, Cristian C. Aragón, Gabriel J. Tobón   +2 more
doaj   +2 more sources

Efficacy of Cathelicidin LL-37 in an MRSA Wound Infection Mouse Model [PDF]

Antibiotics, 2021
Background: LL-37 is the only human antimicrobial peptide that belongs to the cathelicidins. The aim of the study was to evaluate the efficacy of LL-37 in the management of MRSA-infected surgical wounds in mice. Methods: A wound on the back of adult male
Oriana Simonetti, Oscar Cirioni, Gaia Goteri, Guendalina Lucarini, Elżbieta Kamysz, Wojciech Kamysz, Fiorenza Orlando, Giulio Rizzetto, Elisa Molinelli, Gianluca Morroni, Roberto Ghiselli, Mauro Provinciali, Andrea Giacometti, Annamaria Offidani   +13 more
doaj   +2 more sources

Susceptibility of Pseudomonas aeruginosa biofilm to alpha-helical peptides: D-enantiomer of LL-37 [PDF]

Frontiers in Cellular and Infection Microbiology, 2011
Pseudomonas aeruginosa is a highly versatile opportunistic pathogen and its ability to produce biofilms is a direct impediment to the healing of wounds and recovery from infection.
Scott N. Dean, Barney M. Bishop, Monique L Van Hoek   +2 more
doaj   +4 more sources

Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection [PDF]

Frontiers in Immunology, 2020
Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associated with bronchiolitis in infants, pneumonia in immunocompromised patients, and ...
Víctor Casanova, Filipa Henderson Sousa, Priyanka Shakamuri, Pavel Svoboda, Chloé Buch, Mathilde D'Acremont, Maria A. Christophorou, Jan Pohl, Craig Stevens, Peter G. Barlow   +9 more
doaj   +2 more sources

Salivary Cathelicidin (LL-37) in Children and Adolescents Living with HIV [PDF]

Biomedicine Hub
Introduction: Human cathelicidin LL-37 is a salivary antimicrobial peptide (AMP) with broad-spectrum activity against oral diseases, but few studies have assessed its role in children and adolescents living with HIV (CALHIV).
Ana Lucia Seminario, Ashley E. Karczewski, Whasun Chung, Yan Wang, Dalton Wamalwa, Sarah Benki-Nugent, Grace John-Stewart, Jennifer A. Slyker, Arthur Kemoli   +8 more
doaj   +2 more sources

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

PLoS ONE, 2011
The extensive world-wide morbidity and mortality caused by influenza A viruses highlights the need for new insights into the host immune response and novel treatment approaches. Cationic Host Defense Peptides (CHDP, also known as antimicrobial peptides),
Peter G Barlow, Ian A York, Jan Pohl
exaly   +3 more sources