Results 11 to 20 of about 16,226 (208)
Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer [PDF]
Cellular Physiology and Biochemistry, 2018 LL-37, the C-terminal peptide of human cathelicidin antimicrobial peptide (CAMP, hCAP18), reportedly increases resistance to microbial invasion and exerts important physiological functions in chemotaxis, promotion of wound closure, and angiogenesis ...
Xi Chen +6 more
doaj +3 more sources
Engineered Exosomes Containing Cathelicidin/LL-37 Exhibit Multiple Biological Functions. [PDF]
Adv Healthc Mater, 2022 AbstractExosomes show great potential in diagnostic and therapeutic applications. Inspired by the human innate immune defense, herein, we report engineered exosomes derived from monocytic cells treated with immunomodulating compounds 1α,25‐dihydroxyvitamin D3, and CYP24A1 inhibitor VID400 which are slowly released from electrospun nanofiber matrices ...
Su Y +6 more
europepmc +3 more sources
Cathelicidin LL-37 in Health and Diseases of the Oral Cavity. [PDF]
Biomedicines, 2022 The mechanisms for maintaining oral cavity homeostasis are subject to the constant influence of many environmental factors, including various chemicals and microorganisms. Most of them act directly on the oral mucosa, which is the mechanical and immune barrier of the oral cavity, and such interaction might lead to the development of various oral ...
Tokajuk J +8 more
europepmc +5 more sources
Cathelicidin LL-37 Ignites Primed NLRP3 Inflammasomes in Rosacea [PDF]
Journal of Investigative Dermatology, 2021 Microbes and commensal mites contribute to the development of inflammation and neurovascular dysregulation in rosacea. Cathelicidin family proteins are epithelial antimicrobial peptides expressed in higher-order mammals. In humans, mature LL-37 is cleaved from its precursor in response to microbial infection, UV light, and injury.
David O. Croitoru, Vincent Piguet
openaire +2 more sources
Human cathelicidin LL-37 enhance the antibiofilm effect of EGCG on Streptococcus mutans. [PDF]
BMC Oral Health, 2016 Guo YJ, Zhang B, Feng XS, Ren HX, Xu JR.
europepmc +2 more sources
Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. [PDF]
, 2015 BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S.
Gallo, Richard L +6 more
core +10 more sources
Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
Frontiers in Immunology, 2023 Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk.
Qing Zhang +6 more
doaj +1 more source
The Role of Cathelicidin LL-37 in Cancer Development. [PDF]
Arch Immunol Ther Exp (Warsz), 2016 LL-37 is a C-terminal peptide proteolytically released from 18 kDa human cathelicidin protein (hCAP18). Chronic infections, inflammation, tissue injury and tissue regeneration are all linked with neoplastic growth, and involve LL-37 antibacterial and immunomodulatory functions.
Piktel E +8 more
europepmc +5 more sources
Frontiers in Bioscience-Landmark, 2021 Human cathelicidin antimicrobial peptide LL-37 (LL-37) is an antimicrobial peptide derived from its precursor protein hCAP18, which is an only cathelicidin in human.
Keqiang Chen +4 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source