Results 91 to 100 of about 6,173 (199)

The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs

Molecules, 2018
Host-defense peptides, also called antimicrobial peptides (AMPs), whose protective action has been used by animals for millions of years, fulfill many requirements of the pharmaceutical industry, such as: (1) broad spectrum of activity; (2) unlike ...
Alicia Boto, Jose Manuel Pérez de la Lastra, Concepción C. González   +2 more
doaj   +1 more source

In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus

, 2015
Livestock-associated methicillin-resistant S. aureus (LA-MRSA) is an important zoonotic pathogen. An emerging problem in treating S. aureus infections is the increasing resistance against antibiotics. A possible way to overcome this issue is to boost the
Schwarz, Stefan, von Köckritz-Blickwede, M., Kadlec, Kristina, Blodkamp, Stefanie, Gutsmann, T., Naim, H.Y.   +5 more
core   +1 more source

Influences of porcine circo-, arteriviruses and cathelicidins in plasmacytoid dendritic cell-derived interferon-alpha responses [PDF]

, 2014
Type I interferons (IFNs), mainly IFN-α/β play a crucial role in innate defense against viruses. In addition to their direct antiviral activity, type I IFNs have antitumoral and immunomodulatory effects.
Baumann, Arnaud
core   +1 more source

Antimicrobial Peptides as Mediators of Innate Immunity in Teleosts

Biology, 2015
Antimicrobial peptides (AMPs) have been identified throughout the metazoa suggesting their evolutionarily conserved nature and their presence in teleosts is no exception. AMPs are short (18–46 amino acids), usually cationic, amphipathic peptides.
Barbara A. Katzenback
doaj   +1 more source

Novel cathelicidins in horse leukocytes

, 1999
Cathelicidins are precursors of defense peptides of the innate immunity and are widespread in mammals. Their structure comprises a conserved prepropiece and an antimicrobial domain that is structurally varied both intra- and inter-species.
BOSCOLO S., ZANETTI, Margherita, SCOCCHI M., GIULOTTO, ELENA, GIULOTTO E., Tomasinsig L., BONTEMPO D., Zanetti M.   +7 more
core   +2 more sources

Influence of maternal nutrition and one-carbon metabolites supplementation on bovine antimicrobial peptides in fetal and maternal tissues

Frontiers in Veterinary Science
IntroductionMaternal nutrition during pregnancy critically influences offspring development and immune function. One-carbon metabolites (OCM) are epigenetic modifiers that may modulate antimicrobial peptide (AMP) expression, which is vital for innate ...
Mojtaba Daneshi, Pawel P. Borowicz, Mara R. Hirchert, Yssi L. Entzie, Jessica G. Syring, Layla E. King, Kazi Sarjana Safain, Muhammad Anas, Lawrence P. Reynolds, Alison K. Ward, Carl R. Dahlen, Matthew S. Crouse, Joel S. Caton   +12 more
doaj   +1 more source

Cathelicidins positively regulate pancreatic beta-cell functions

, 2016
Cathelicidins are pleiotropic antimicrobial peptides largely described for innate antimicrobial defenses and, more recently, immunomodulation. They are shown to modulate a variety of immune or nonimmune host cell responses. However, how cathelicidins are
Gudmundsson, Gudmundur H.,, Xu, Meng,, Ortsäter, Henrik,, Lundeberg, Erik,, Agerberth, Birgitta,, Haeggström, Jesper Z.,, Diana, Julien,, Sun, Jia,, Chen, Yong Q.,, Juntti-Berggren, Lisa,   +9 more
core   +1 more source

Cathelicidins display conserved direct antiviral activity towards rhinovirus

, 2017
Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised individuals and patients with pre-existing pulmonary conditions.
Casanova, Victor, Barlow, Peter G., Victor Casanova, Stevens, Craig, Lorna Proudfoot, Sousa, Filipa Henderson, Svoboda, Pavel, Fern Findlay, Filipa Henderson Sousa, Craig Stevens, Proudfoot, Lorna, Pohl, Jan, Pavel Svoboda, Peter G. Barlow, Findlay, Fern, Jan Pohl   +15 more
core   +2 more sources

Human Antimicrobial Peptides as Therapeutics for Viral Infections

Viruses, 2019
Successful in vivo infection following pathogen entry requires the evasion and subversion of multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune pathways upregulated during infection by multiple pathogens, in ...
Aslaa Ahmed, Gavriella Siman-Tov, Grant Hall, Nishank Bhalla, Aarthi Narayanan   +4 more
doaj   +1 more source

Role of antimicrobial peptides in periodontal innate defense mechanism

Journal of Oral Research and Review, 2015
The periodontal epithelium neighboring the tooth is precise to form a seal and attachment around the tooth. This exclusive function imparts unique challenges to the tissue and leads to certain vulnerabilities allied with periodontal disease, particularly
Ashank Mishra, Bagalkotkr Apeksha, Pradeep Koppolu, Swapna Amara Lingam   +3 more
doaj   +1 more source