Results 71 to 80 of about 3,232 (162)

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Cathelicidins in the Tasmanian devil (Sarcophilus harrisii)

, 2016
Tasmanian devil joeys, like other marsupials, are born at a very early stage of development, prior to the development of their adaptive immune system, yet survive in a pathogen-laden pouch and burrow.
Djordjevic, J. T., Sorrell, T. C., Fox, S., Peel, E., Belov, K., Cheng, Y.   +5 more
core   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, Volume 104, Issue 10, Page 975-986, November‐December 2026.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

Exploring the Antimicrobial and Immunomodulatory Potential of Gecko-Derived Cathelicidin Gj-CATH5

Biomolecules
Regulating the innate immune response against infections, particularly drug-resistant bacteria, is a key focus in anti-infection therapy. Cathelicidins, found in vertebrates, are crucial for pathogen resistance.
Shasha Cai, Ningyang Gao, Junhan Wang, Jing Li   +3 more
doaj   +1 more source

Imaging the Antistaphylococcal Activity of CATH-2: Mechanism of Attack and Regulation of Inflammatory Response

mSphere, 2017
Chicken cathelicidin-2 (CATH-2) is a broad-spectrum antimicrobial host defense peptide (HDP) that may serve as a paradigm for the development of new antimicrobial agents.
Viktoria A. F. Schneider, Maarten Coorens, Johanna L. M. Tjeerdsma-van Bokhoven, George Posthuma, Albert van Dijk, Edwin J. A. Veldhuizen, Henk P. Haagsman   +6 more
doaj   +1 more source

From Dysbiosis to Disease: How Vaginal Microbiota Shape Group B Streptococcus Pathogenesis

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
Lactobacillus crispatus plays a critical role in the vaginal microbiome. Limiting glucose shifts metabolism toward HMO consumption and amino acid metabolism. These actions enable alkali production and competition. Homeostasis, characterized by dense Lactobacilli colonization and suppression of pathogens, provides resistance to dysbiosis.
Julie A. Talbert, Steven D. Townsend
wiley   +1 more source

Cathelicidins inhibit Escherichia coli-induced TLR2 and TLR4 activation in a viability-dependent manner [PDF]

, 2017
Activation of the immune system needs to be tightly regulated to provide protection against infections and, at the same time, to prevent excessive inflammation to limit collateral damage to the host.
Albert van Dijk, Dep Infectieziekten Immunologie, dI&I I&I-3, dI&I RA-I&I I&I, de Groot, A Marit, Haagsman, Henk P., Coorens, Maarten, Henk P. Haagsman, Groot, A.M., De, Scheenstra, Maaike R., Viktoria A. F. Schneider, van Dijk, Albert, Wells, Jerry M, Schneider, Viktoria A.F., Veldhuizen, Edwin J A, Veldhuizen, Edwin J.A., Maaike R. Scheenstra, Scheenstra, Maaike R, Schneider, Viktoria A F, Marjolein Meijerink, Haagsman, Henk P, Dijk, Albert I.J.M., Van, Infection & Immunity, A. Marit de Groot, Edwin J. A. Veldhuizen, Wells, Jerry M., Jerry M. Wells, Maarten Coorens, Meijerink, Marjolein   +28 more
core   +1 more source

The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs

Molecules, 2018
Host-defense peptides, also called antimicrobial peptides (AMPs), whose protective action has been used by animals for millions of years, fulfill many requirements of the pharmaceutical industry, such as: (1) broad spectrum of activity; (2) unlike ...
Alicia Boto, Jose Manuel Pérez de la Lastra, Concepción C. González   +2 more
doaj   +1 more source

Cathelicidin host defence peptide augments clearance of pulmonary Pseudomonas aeruginosa infection by its influence on neutrophil function in vivo.

PLoS ONE, 2014
Cathelicidins are multifunctional cationic host-defence peptides (CHDP; also known as antimicrobial peptides) and an important component of innate host defence against infection.
Paula E Beaumont, Brian McHugh, Emily Gwyer Findlay, Annie Mackellar, Karen J Mackenzie, Richard L Gallo, John R W Govan, A John Simpson, Donald J Davidson   +8 more
doaj   +1 more source

Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides

, 1996
Cathelicidins are a novel family of antimicrobial peptide precursors from mammalian myeloid cells. They are characterized by a conserved N-terminal region while the C-terminal antimicrobial domain can vary considerably in both primary sequence and length.
Brigita Lenarcic, TOSSI, ALESSANDRO, Alessandro Tossi, Domenico Romeo, P. STORICI, B. LENARCIC, ROMEO, DOMENICO, Paola Storici   +7 more
core   +1 more source