Results 71 to 80 of about 5,375 (171)

LL‐37: Biological Mechanisms and Emerging Therapeutic Applications in Intestinal Disease

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Human cathelicidin peptide LL‐37 is encoded by the CAMP gene and plays a key role in innate immunity. It maintains intestinal homeostasis through antibacterial, immunomodulation, and tissue repair functions. This paper reviews the multiple functions of LL‐37 in the intestinal‐immune axis and its contribution to intestinal immune homeostasis. A
Qichao Liu, Peng Xu, Cheng Zhang
wiley   +1 more source

Role of Cathelicidins in Atherosclerosis and Associated Cardiovascular Diseases

Journal of Molecular Pathology
Cathelicidins (human LL-37 and rat CRAMP) are multifunctional peptides involved in various cardiovascular conditions. This review integrates the recent findings about the functional involvement of LL-37/CRAMP across atherosclerosis, acute coronary ...
Siarhei A. Dabravolski, Nikolay A. Orekhov, Alexey V. Churov, Irina A. Starodubtseva, Dmitry F. Beloyartsev, Tatiana I. Kovyanova, Vasily N. Sukhorukov, Alexander N. Orekhov   +7 more
doaj   +1 more source

Association of Milk C‐Reactive Protein With Subclinical Mastitis in Dairy Buffaloes

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Milk C‐reactive protein (CRP) concentrations were significantly increased in subclinical mastitis‐positive mammary lobe samples from dairy buffaloes and were consistent with somatic cell count and bacteriological findings, indicating that milk CRP reflects mammary inflammatory activity.
Ahmet Sabuncu, Sinem Özlem Enginler, Gamze Evkuran Dal, Atila Ateş, Baran Çelik, Serkan Ikiz, Ömür Koçak, Aslıhan Baykal Uğur   +7 more
wiley   +1 more source

A Botanical Mixture of Boswellia serrata, Commiphora myrrha, Propolis and Scutellaria baicalensis Reduces Expression of Inflammatory Chemokines in Canine Keratinocytes In Vitro

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
YSK‐AB, a botanical mixture, reduced nitric oxide production in RAW 264.7 cells and chemokine expression in canine keratinocytes, suggesting its potential as a natural therapeutic agent for inflammatory skin diseases in dogs. ABSTRACT Background Botanical ingredients can function as adjunctive therapies for managing inflammatory skin diseases ...
Danbee Ha, Kyungsook Jung, Hyungyeong Choi, Ji‐Seon Yoon   +3 more
wiley   +1 more source

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source

Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik, Shreya Joshi, Aisha Nazli, Charu Kaushic   +3 more
wiley   +1 more source

The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs

Molecules, 2018
Host-defense peptides, also called antimicrobial peptides (AMPs), whose protective action has been used by animals for millions of years, fulfill many requirements of the pharmaceutical industry, such as: (1) broad spectrum of activity; (2) unlike ...
Alicia Boto, Jose Manuel Pérez de la Lastra, Concepción C. González   +2 more
doaj   +1 more source

Phage Therapy: Targeting the Gut Microbiota for the Treatment of Acute Pancreatitis

Journal of Gastroenterology and Hepatology, Volume 41, Issue 5, Page 1446-1458, May 2026.
ABSTRACT Acute pancreatitis (AP) is a common clinical inflammatory condition whose severity is closely associated with both local pancreatic injury and systemic complications. Research indicates that gut microbiota dysbiosis and subsequent bacterial translocation can exacerbate disease progression via the gut–pancreas axis, representing a critical ...
Jiawei Chen, Caihan Duan, Keyi Zhang, Jun Liu, Chaoqun Han   +4 more
wiley   +1 more source

Influence of maternal nutrition and one-carbon metabolites supplementation on bovine antimicrobial peptides in fetal and maternal tissues

Frontiers in Veterinary Science
IntroductionMaternal nutrition during pregnancy critically influences offspring development and immune function. One-carbon metabolites (OCM) are epigenetic modifiers that may modulate antimicrobial peptide (AMP) expression, which is vital for innate ...
Mojtaba Daneshi, Pawel P. Borowicz, Mara R. Hirchert, Yssi L. Entzie, Jessica G. Syring, Layla E. King, Kazi Sarjana Safain, Muhammad Anas, Lawrence P. Reynolds, Alison K. Ward, Carl R. Dahlen, Matthew S. Crouse, Joel S. Caton   +12 more
doaj   +1 more source

[Cathelicidins - endogenous antimicrobial peptides].

Postepy biochemii, 2015
Within the last decade, several antimicrobial peptides (AMPs) have been discovered. Cathelicidins are one family of AMPs characterized by a conserved cathelin domain and a variable C-terminal cationic antimicrobial domain. These peptides are produced by different cells, including leukocytes, epithelial cells and keratinocytes.
Karolina, Wódz, Ewa, Brzezińiska-Błaszczyk   +1 more
openaire   +1 more source