Results 141 to 150 of about 106,246 (275)

Deciphering the role of cathepsins in digestive system cancers: a Mendelian randomization study

Discover Oncology
Digestive system cancers (DSCs) present a global health challenge. This study aimed to investigate the causal relationships between cathepsins and DSCs using Mendelian Randomization (MR) analysis.
Beian Guo, Zhiyi Zhou, Wanzhe Liao, Yurong Zheng, Yinjie Liao, Ruiqi Zeng   +5 more
doaj   +1 more source

Role of Cathepsin G in Rheumatoid Arthritis Diagnosis and Disease Activity Evaluation

مجلة الكوفة الطبية
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects 1% of the world's population. It causes chronic inflammation of synovial tissue, leading to joint destruction, poor quality of life, and disability.
Mays Saleh Khamees, Raad Abdulameer Alasady   +1 more
doaj   +1 more source

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Trivalent chromium supplementation ameliorates adjuvant induced rheumatoid arthritis through up-regulation of FOXP3 and decrease in synovial Cathepsin G expression. [PDF]

Inflammopharmacology, 2022
Hassouna SS, Sheta E, Zaki I, Harby SA, Allam EA.   +4 more
europepmc   +1 more source

Proteolytic enzyme systems [PDF]

, 1993
Fritz, Hans, Jochum, Marianne, Machleidt, W., Redl, H., Schlag, Günther   +4 more
core   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Activity-Based Probes to Utilize the Proteolytic Activity of Cathepsin G in Biological Samples. [PDF]

Front Chem, 2021
Burster T, Gärtner F, Knippschild U, Zhanapiya A.   +3 more
europepmc   +1 more source

Role of leukocytes in hemostasis during orthotopic liver transplantation [PDF]

, 1993
Bechstein, W. O., Himmelreich, G., Huhn, D., Jochum, Marianne, Machleidt, W., Muser, M., Neuhaus, P., Riess, H., Roissaint, R.   +8 more
core   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Low Concentration of the Neutrophil Proteases Cathepsin G, Cathepsin B, Proteinase-3 and Metalloproteinase-9 Induce Biofilm Formation in Non-Biofilm-Forming Staphylococcus epidermidis Isolates. [PDF]

Int J Mol Sci, 2022
Gómez-Alonso IS, Martínez-García S, Betanzos-Cabrera G, Juárez E, Sarabia-León MC, Herrera MT, Gómez-Chávez F, Sanchez-Torres L, Rodríguez-Martínez S, Cancino-Diaz ME, Cancino J, Cancino-Diaz JC.   +11 more
europepmc   +1 more source