Results 251 to 260 of about 106,246 (275)
Some of the next articles are maybe not open access.
Stimulation of human lymphocytes by cathepsin G
Cellular Immunology, 1995We investigated the effect of cathepsin G, a serine protease in polymorphonuclear granulocytes, on the function of human lymphocytes. Cathepsin G increased the [3H]thymidine incorporation into human lymphocytes. This mitogenic activity was due to the proteolytic activity of cathepsin G.
T, Hase-Yamazaki, Y, Aoki
openaire +2 more sources
Antibodies to Cathepsin G in Crohn's disease
European Journal of Clinical Investigation, 1992Abstract. Antibodies directed against antigens in human neutrophils have proved to be of great diagnostic value in certain systemic vasculitides. Recent reports have focused the attention on these antigens as targets of antibodies in sera of patients with inflammatory bowel disease. We investigated the sera drawn from 60 patients suffering from biopsy
W. J. MAYET +6 more
openaire +2 more sources
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1992
The neutrophil-activating peptide-2 (NAP-2) is a cytokine that is generated by the proteolytic cleavage of a precursor protein and that causes neutrophil degranulation and chemotaxis. NAP-2 precursors are produced in platelets and are normally found in the circulation. We showed that NAP-2 is generated by the action of neutrophil cathepsin G on two of
A B, Cohen +4 more
openaire +2 more sources
The neutrophil-activating peptide-2 (NAP-2) is a cytokine that is generated by the proteolytic cleavage of a precursor protein and that causes neutrophil degranulation and chemotaxis. NAP-2 precursors are produced in platelets and are normally found in the circulation. We showed that NAP-2 is generated by the action of neutrophil cathepsin G on two of
A B, Cohen +4 more
openaire +2 more sources
Low-Molecular-Weight Aldehyde Inhibitors of Cathepsin G
Protein & Peptide Letters, 2009A series of aldehyde inhibitors with the general formula Ac-Phe-Val-Thr-X-CHO, where X = Lys, Arg, Phe, Tyr, p-nitro-L-phenylalanine (Nif), p-amino-L-phenylalanine (Amf), p-guanidine-L-phenylalanine (Gnf), pyridyl-L-alanine (Pal), was synthesized. The starting structure of this series based on our previous work on cathepsin G chromogenic substrates ...
Adam, Lesner +4 more
openaire +2 more sources
The Hematology Journal, 2001
Preliminary studies have shown that high molecular mass kininogen (HK) inhibits cathepsin G-induced platelet activation. However, the potential mechanism underlying this inhibitory effect remains to be elucidated.Suspensions of washed and gel-filtered platelets were used in radioligand binding and aggregation studies.
T E, Selim +4 more
openaire +2 more sources
Preliminary studies have shown that high molecular mass kininogen (HK) inhibits cathepsin G-induced platelet activation. However, the potential mechanism underlying this inhibitory effect remains to be elucidated.Suspensions of washed and gel-filtered platelets were used in radioligand binding and aggregation studies.
T E, Selim +4 more
openaire +2 more sources
Normal Neutrophil Function in Cathepsin G-Deficient Mice
Blood, 1999Cathepsin G is a neutral serine protease that is highly expressed at the promyelocyte stage of myeloid development. We have developed a homologous recombination strategy to create a loss-of-function mutation for murine cathepsin G. Bone marrow derived from mice homozygous for this mutation had no detectable cathepsin G protein or activity, indicating ...
D M, MacIvor +5 more
openaire +2 more sources
Immunohistochemical localization of cathepsin G in human tissues
The American Journal of Surgical Pathology, 1985An antiserum to human cathepsin G has been raised in sheep and its reactivity with human tissues has been tested. The indirect immunoperoxidase staining sequence was employed and was applied to routinely processed paraffin sections. Mature granulocytes, especially those of the neutrophil variety, were intensely and consistently stained.
J, Crocker, R, Jenkins, D, Burnett
openaire +2 more sources
1981
Publisher Summary This chapter presents the procedure for purification and assaying of cathepsin G. Cathepsin G is purified from human neutrophil leukocytes. Cathepsin G is eluted from the carboxymethyl-cellulose column at a higher salt concentration than the elastase.
openaire +1 more source
Publisher Summary This chapter presents the procedure for purification and assaying of cathepsin G. Cathepsin G is purified from human neutrophil leukocytes. Cathepsin G is eluted from the carboxymethyl-cellulose column at a higher salt concentration than the elastase.
openaire +1 more source
Cathepsin G from human polymorphonuclear leukocytes cleaves human IgM
Molecular Immunology, 1982Cathepsin G, the chymotrypsin-like enzyme from human polymorphonuclear leukocytes, cleaves human IgM and produces two major fragments that closely resemble those released by leukocyte elastase digestion of IgM. An F(ab)2 mu-like fragment, mol. wt 140,000, retains some reactivity with an anti-Fc mu antiserum and is antigenically deficient with respect ...
A, Baici, M, Knöpfel, K, Fehr
openaire +2 more sources
Turnover and distribution of cathepsin G in the rat
Scandinavian Journal of Clinical & Laboratory Investigation, 1993The turnover of 125I labelled rat polymorphonuclear leukocyte (PMN) cathepsin G with retained enzymatic activity was followed 180 min after an intravenous injection. The plasma half-life of injected radioactivity was approximately 4.5 min. In the plasma sample 15 min after injection the main part of the radioactivity in a gel filtration eluted at the ...
P, Björk +3 more
openaire +2 more sources