Results 21 to 30 of about 11,881,546 (284)

Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma

Frontiers in Oncology, 2021
AimWe have previously demonstrated the presence of two cancer stem cell (CSC) subpopulations within metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC) expressing components of the renin-angiotensin system (RAS), which promotes ...
Felix Humphries, Bridget Chang-McDonald, Josie Patel, Nicholas Bockett, Erin Paterson, Paul F. Davis, Swee T. Tan, Swee T. Tan, Swee T. Tan   +8 more
doaj   +1 more source

IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells [PDF]

, 2012
The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the
Kraus, Steffen, Bunsen, Thea, Fruth, Maximilian, Nägler, Dorit K.   +3 more
core   +1 more source

Giardia duodenalis Surface Cysteine Proteases Induce Cleavage of the Intestinal Epithelial Cytoskeletal Protein Villin via Myosin Light Chain Kinase. [PDF]

PLoS ONE, 2015
Giardia duodenalis infections are among the most common causes of waterborne diarrhoeal disease worldwide. At the height of infection, G. duodenalis trophozoites induce multiple pathophysiological processes within intestinal epithelial cells that ...
Amol Bhargava, James A Cotton, Brent R Dixon, Lashitew Gedamu, Robin M Yates, Andre G Buret   +5 more
doaj   +1 more source

A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci [PDF]

, 2011
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Francis, S. E., Calogero Tulone, Read, R. C., Sheila E. Francis, Mitchell, T.J., Read Robert C., Benny Chain, Marriott, Helen M, Deretic, V., Dockrell, David H, Marriott, H.M., Francis, Sheila E, Dockrell, David H., Whyte, M.K.B., Martin A. Bewley, Mitchell Timothy J., Timothy J Mitchell, Whyte, Moira K B, Kroemer, G., Chain, B., Moira K. B. Whyte, Helen M Marriott, Sheila E Francis, Tulone Calogero, Robert C Read, Bewley, M.A., Dockrell, D.H., Whyte Moira K. B., Whyte, Moira K. B., Marriott Helen M., Read, Robert C., Marriott, H. M., Chain, Benny, Tulone, C., Read, R.C., Mitchell, Timothy J., Whyte, Moira K.B., David H. Dockrell, Mitchell, Timothy J, Francis Sheila E., David H Dockrell, Kroemer, Guido, Moira K B Whyte, Marriott, Helen M., Chain Benny, Mitchell, T. J., Timothy J. Mitchell, Bewley, Martin A, Dockrell, D. H., Read, Robert C, Tulone, Calogero, Francis, S.E., Robert C. Read, Dockrell David H., Bewley, Martin A., Martin A Bewley, Helen M. Marriott, Bewley, M. A., Dockrell, David, Bewley Martin A., Whyte, M. K. B., Guido Kroemer, Francis, Sheila E., Kroemer Guido   +63 more
core   +1 more source

In vitro interaction of hormone-conditioned neutrophils with commensal and uropathogenic Escherichia coli biofilms

Инфекция и иммунитет, 2020
The aim of the work was to examine an interaction between neutrophils conditioned with chorionic gonadotropin, estriol, kisspeptin, leptin, ghrelin and commensal and uropathogenic Escherichia coli biofilms.
I. L. Maslennikova, I. V. Nekrasova, E. G. Orlova, O. L. Gorbunova, S. V. Shirshev   +4 more
doaj   +1 more source

Involvement of cathepsin B in the plant disease resistance hypersensitive response [PDF]

, 2007
A diverse range of plant proteases are implicated in pathogen perception and in subsequent signalling and execution of disease resistance. We demonstrate, using protease inhibitors and virus-induced gene silencing (VIGS), that the plant papain cysteine ...
Shaw, Jane, Hein, I., Christophe Lacomme, Kaffarnik, Florian, Hein, Ingo, Lopez, Eduardo C., Eduard Venter, Van Der Hoorn, Renier, Paul R. J. Birch, Pritchard, L., Borras-Hidalgo, Orlando, Hazel McLellan, Gilroy, Eleanor M., McLellan, H., Eleanor M. Gilroy, Hrubikova, Katarina, Birch, P., Orlando Borras-Hidalgo, Boevink, P., Eduardo C. López, Shaw, J., Maria Holeva, Jane Shaw, Loake, Gary J., Hrubikova, K., Katarina Hrubikova, Boevink, Petra C., Holeva, Maria, Venter, Eduard, Kaffarnik, F., McLellan, Hazel, Van der Hoorn, R., Venter, E., Lopez, E., Gary J. Loake, Hein, Ingo; id_orcid, Florian Kaffarnik, Renier Van Der Hoorn, Birch, Paul R. J.; id_orcid, Lacomme, Christophe, Loake, G., Borras-Hidalgo, O., Pritchard, Leighton, Lacomme, C., Ingo Hein, Birch, Paul R. J., Leighton Pritchard, Holeva, M., Gilroy, E., Petra C. Boevink   +49 more
core   +1 more source

Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis

iScience, 2023
Summary: The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not well ...
Won Ho Yang, Peter V. Aziz, Douglas M. Heithoff, Yeolhoe Kim, Jeong Yeon Ko, Jin Won Cho, Michael J. Mahan, Markus Sperandio, Jamey D. Marth   +8 more
doaj   +1 more source

Cathepsin G: Roles in antigen presentation and beyond [PDF]

Molecular Immunology, 2010
Contributions from multiple cathepsins within endosomal antigen processing compartments are necessary to process antigenic proteins into antigenic peptides. Cysteine and aspartyl cathepsins have been known to digest antigenic proteins. A role for the serine protease, cathepsin G (CatG), in this process has been described only recently, although CatG ...
Timo, Burster, Henriette, Macmillan, Tieying, Hou, Bernhard O, Boehm, Elizabeth D, Mellins   +4 more
openaire   +2 more sources

Expression and Localization of Cathepsins B, D and G in Cancer Stem Cells in Liver Metastasis From Colon Adenocarcinoma

Frontiers in Surgery, 2018
AimWe have previously identified and characterized cancer stem cell (CSC) subpopulations in liver metastasis from colon adenocarcinoma (LMCA). In this study we investigated the expression and localization of cathepsins B, D and G, in relation to these ...
Shreeja Mehrotra, Susrutha K. Wickremesekera, Susrutha K. Wickremesekera, Helen D. Brasch, Bede Van Schaijik, Reginald W. Marsh, Reginald W. Marsh, Swee T. Tan, Swee T. Tan, Tinte Itinteang   +9 more
doaj   +1 more source

Human cathepsin G. Catalytic and immunological properties [PDF]

Biochemical Journal, 1976
1. The specificity of cathepsin G, a neutral proteinase from human spleen, was examined by use of low-molecular-weight substrates. The enzyme was found to hydrolyse several synthetic substrates also hydrolysed by chymotrypsin, but with different kinetic constants. 2.
P M, Starkey, A J, Barrett
openaire   +2 more sources