Results 161 to 170 of about 108,576 (328)

Clinical trial of safety and antitumor activity of farletuzumab ecteribulin in patients with platinum‐resistant ovarian cancer: Phase I expansion results

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective In the dose‐escalation part of Study 101, which included multiple tumor types, objective responses were observed in 10 of 22 patients across multiple dose levels of farletuzumab ecteribulin (FZEC). We explored the safety/antitumor activity of FZEC in patients with platinum‐resistant ovarian cancer (PROC) from the Study 101 expansion ...
Kan Yonemori, Mayu Yunokawa, Koji Matsumoto, Kazuhiro Takehara, Kosei Hasegawa, Yasuyuki Hirashima, Hidenori Kato, Hiroki Ikezawa, Yohei Otake, Wataru Yusa, Takuma Miura, Shin Nishio   +11 more
wiley   +1 more source

Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation

, 2019
Tommy Weiss‐Sadan, Gal Itzhak, Farnusch Kaschani, Zhanru Yu, Mohamed Mahameed, Adi Anaki, Yael Ben‐Nun, Emmanuelle Merquiol, Boaz Tirosh, Benedikt M. Kessler, Markus Kaiser, Galia Blum   +11 more
openalex   +1 more source

Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts [PDF]

, 2011
Dongwei Zhang, Chuangfang Huang, Changfu Yang, Renzuo J Liu, Jifeng Wang, Jianzhao Niu, Dieter Brömme   +6 more
openalex   +1 more source

Effect of calcium chloride injection and freezing prior to wet aging on the meat quality of cull cows

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND In Brazil, the slaughter of female cattle, particularly older animals, has increased substantially. However, meat from this category presents limitations in terms of quality, mainly because of its toughness resulting from a high concentration of cross‐links between collagen fibers.
Juliano CC Belmonte, Taynara S Santana, Micheline F Castro, Rosileide V Rohod, Marcelo Vedovatto, Aylpy RD Santos, Henrique J Fernandes, Dalton M Oliveira   +7 more
wiley   +1 more source

Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase

JCI Insight
The glucocerebrosidase (GCase) encoded by the GBA1 gene hydrolyzes glucosylceramide (GluCer) to ceramide and glucose in lysosomes. Homozygous or compound heterozygous GBA1 mutations cause the lysosomal storage disease Gaucher disease (GD) due to severe ...
Myung Jong Kim, Soojin Kim, Thomas Reinheckel, Dimitri Krainc   +3 more
doaj   +1 more source

Anaplasma phagocytophilumIncreases Cathepsin L Activity, Thereby Globally Influencing Neutrophil Function

, 2008
Venetta Thomas, Swapna Samanta, Erol Fikrig   +2 more
openalex   +2 more sources

Hairpin loop mutations of chicken cystatin have different effects on the inhibition of cathepsin B, cathepsin L and papain [PDF]

, 1995
Ennes A. Auerswald, Dorit K. Nägler, Irmgard Assfalg‐Machleidt, Milton T. Stubbs, Werner Machleidt, Hans Fritz   +5 more
openalex   +1 more source

Antimicrobial Cyclic Peptidomimetics

Macromolecular Rapid Communications, EarlyView.
Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley   +1 more source

Proteolytic enzyme systems [PDF]

, 1993
Fritz, Hans, Jochum, Marianne, Machleidt, W., Redl, H., Schlag, Günther   +4 more
core   +1 more source

Tumor Cell Migration May Be an Inherent “Foraging” Behavior

Medicine Advances, EarlyView.
Tumor cells gradually form pseudopodia, migrate to necrotic cells, make contact with them, and absorb necrotic cell debris. During this migration, small vesicles formed by dying tumor cells also gradually migrate toward living tumor cells. Once the nutrients from the necrotic cells have been completely absorbed, the living tumor cells will leave ...
Fuqian Zhao, Hongmei Niu, Lusi Zhang, Daofu Shen, Lei Wang   +4 more
wiley   +1 more source