Results 161 to 170 of about 16,299,323 (310)

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

Fluorescence Polarization-Based High-Throughput Screening Assay for Inhibitors Targeting Cathepsin L. [PDF]

Bio Protoc
Guo K, You B, Zhou W, Li Y, Wang Z, Zhang J, Si S.   +6 more
europepmc   +1 more source

Physicochemical characterization of etch‐and‐rinse adhesive system doped with catechin‐loaded polymeric microparticles

European Journal of Oral Sciences, EarlyView.
Abstract This study evaluated the incorporation of epigallocatechin‐3‐gallate (EGCG)‐loaded poly(lactide‐co‐glycolide) (PLGA) microparticles into a two‐step etch‐and‐rinse adhesive and their effects on physicochemical properties and EGCG release. EGCG was added to Single Bond 2 either directly (0.01% and 0.1% w/w) or encapsulated in PLGA 50:50 or 75:25
Jiovanne Rabelo Neri, Nadine Luisa Guimarães Albuquerque, Marcelo Victor Sidou Lemos, Monica Yamauti, Francisco Fábio Oliveira de Sousa, Vanara Florêncio Passos, Sérgio Lima Santiago   +6 more
wiley   +1 more source

Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1. [PDF]

Nat Commun
Park SY, Son K, Kim J, Kim K, Joo S, Kim B, Lee M, Kim W, Jung WJ, Choi BK, Jeon N, Chung WY, Hu Y, Lee H, Song NY.   +14 more
europepmc   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Correction: Dynamic expression of cathepsin L in the black soldier fly (Hermetia illucens) gut during Escherichia coli challenge. [PDF]

PLoS One
Chiang YR, Lin HT, Chang CW, Lin SM, Lin JH.   +4 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation. [PDF]

J Virol
Chen Y, Shi Y, Zuo X, Dong X, Xiao X, Chen L, Xiang Z, Ren L, Zhou Z, Wei W, Lei X, Wang J.   +11 more
europepmc   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

The lysosomal cysteine protease cathepsin L promotes stemness and multidrug resistance of non-small cell lung cancer by targeting HGF activator. [PDF]

Mol Cell Biochem
Shi H, Xu J, Wu J, Hu S, Chen X, Hu Q, Liu Q, Yu Y, Ding X, Wang W.   +9 more
europepmc   +1 more source