Results 71 to 80 of about 47,172 (255)
Advanced Science, EarlyView.Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley +1 more source
Mast cell subsets and their functional modulation by the Acanthocheilonema viteae product ES-62 [PDF]
, 2013 ES-62, an immunomodulator secreted by filarial nematodes, exhibits therapeutic potential in mouse models of allergic inflammation, at least in part by inducing the desensitisation of Fc휀RI-mediated mast cell responses.
Al-Riyami, Lamyaa +7 more
core +2 more sources
Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination
eLife, 2017 Several human diseases are associated with a lack of caveolae. Yet, the functions of caveolae and the molecular mechanisms critical for shaping them still are debated.
Eric Seemann +11 more
doaj +1 more source
Hyperosmolarity Impairs Human Extravillous Trophoblast Differentiation by Caveolae Internalization
Frontiers in Physiology, 2021 We recently reported that an intact caveolar structure is necessary for adequate cell migration and tubulogenesis of the human extravillous trophoblast (EVT) cells.
Julieta Reppetti +5 more
doaj +1 more source
Endothelial Cell‐Based Vascular Bandages for Blood–Brain Barrier Repair and Targeted siRNA Delivery
Advanced Science, EarlyView.mECs restore blood–brain barrier function after cerebral ischemia–reperfusion by simultaneously targeting, supporting, and regulating the damaged vasculature. mECs home to injured cerebral vessels through interactions with highly expressed VLA‐4, reinforce endothelial integrity by forming new junctions, and, upon OGD‐SN treatment, acquire enhanced ...
Yaosheng Li +23 more
wiley +1 more source
Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]
, 2013 Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska +54 more
core +2 more sources
Advanced Science, EarlyView.A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang +14 more
wiley +1 more source
Caveolae and Lipid Rafts in Endothelium: Valuable Organelles for Multiple Functions
Biomolecules, 2020 Caveolae are flask-shaped invaginations of the plasma membrane found in numerous cell types and are particularly abundant in endothelial cells and adipocytes.
Antonio Filippini, Alessio D’Alessio
doaj +1 more source
Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders
Advanced Science, EarlyView.Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li +7 more
wiley +1 more source
Caveolin-1 expression and cavin stability regulate caveolae dynamics in adipocyte lipid store fluctuation [PDF]
, 2014 Adipocytes specialized in the storage of energy as fat are among the most caveolae-enriched cell types. Loss of caveolae produces lipodystrophic diabetes in humans, which cannot be reversed by endothelial rescue of caveolin expression in mice, indicating
C. Prado +8 more
core +4 more sources