Results 91 to 100 of about 56,717 (240)

Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy for Primary Breast Cancer Comparing Interim Shear Wave Elastography Versus Magnetic Resonance Imaging

Journal of Ultrasound in Medicine, EarlyView.
Objectives The prediction of pathological complete response (pCR) of primary breast cancer to neoadjuvant chemotherapy (NAC) is crucial for guiding surgical decisions. This study examined the effectiveness of shear wave elastography (SWE) compared with magnetic resonance imaging (MRI) in predicting the response to NAC in patients with breast lesions ...
Alessandro Garlaschi, Nicole Brunetti, Simona Tosto, Licia Gristina, Piero Fregatti, Massimo Calabrese, Alberto Stefano Tagliafico   +6 more
wiley   +1 more source

Caveolin-1 protects B6129 mice against Helicobacter pylori gastritis. [PDF]

, 2013
Caveolin-1 (Cav1) is a scaffold protein and pathogen receptor in the mucosa of the gastrointestinal tract. Chronic infection of gastric epithelial cells by Helicobacter pylori (H. pylori) is a major risk factor for human gastric cancer (GC) where Cav1 is
A Bist, A Lee, A Muller, AB Rogers, AS Day, B Razani, C Pelz, C Wunder, CG Hansen, CH Kuo, CH Lai, CH Lai, Christoph Röcken, Claus Schäfer, CM Rosenberger, D Engel, D Forman, D Makola, DW Zaas, E Burgermeister, E Burgermeister, E Burgermeister, E Prade, E Touati, E Touati, Elke Burgermeister, F Lian, F Sommer, FA Medina, FA Medina, FA Medina, Florian Anderl, FS Machado, G Li, G Soong, Gang Yuan, I Mercier, I Regel, IC Arnold, IC Arnold, IC Arnold, IM Toller, Ivana Hitkova, J Li, J Millan, JC Atherton, JE Crabtree, JG Fox, JH Chidlow Jr, JP Boettcher, JS Low, JW Yam, K Ohnuma, K Simons, K Yuan, KM Bourzac, LJ Thompson, M Beigier-Bompadre, M Gadjeva, M Hatakeyama, M Kurayoshi, M Mohammadi, M Yamaga, Markus Gerhard, Matthias P. A. Ebert, MF Dixon, MJ Zhang, ML Hutton, MM D'Elios, MP Ebert, MP Ebert, MR Amieva, NE van Doorn, OA Senkovich, P Gargalovic, P Kundu, P Lajoie, PU Le, R Palovuori, R Rad, R Tsutsumi, Roger Vogelmann, Roland M. Schmid, S Li, S Moese, S Thomas, Simone Reu, Steven R. Blanke, T Kawazoe, T Tomassian, TH Tsai, Thomas Kirchner, TI Jeon, TM Williams, TM Williams, TY Kim, VM Pietiainen, W Schraw, X Cao, X Xing, Y Churin, Y Mitsuno, Y Yamaoka, YC Liao   +103 more
core   +4 more sources

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources

Nitroglycerin Tolerance in Caveolin-1 Deficient Mice

PLoS ONE, 2014
Nitrate tolerance developed after persistent nitroglycerin (GTN) exposure limits its clinical utility. Previously, we have shown that the vasodilatory action of GTN is dependent on endothelial nitric oxide synthase (eNOS/NOS3) activity. Caveolin-1 (Cav-1) is known to interact with NOS3 on the cytoplasmic side of cholesterol-enriched plasma membrane ...
Farnaz R. Bakhshi, Marcelo G. Bonini, Olga Chernaya, Sudhahar Varadarajan, Mao Mao, Tohru Fukai, Samuel C. Dudley, Richard D. Minshall   +7 more
openaire   +5 more sources

The effects and mechanisms of stem cells and exosomes on neurological function protection and recovery after ischemic stroke

Neuroprotection, EarlyView.
Effect and mechanism of stem cells and exosomes therapy in ischemic stroke. The effect and mechanism include protection of neuron and glial cells, repairment of nerve vascular unit, reduction of inflammation response, restoration of white matter integrity, reconstruction of neural circuit, replacement of neurons and glial cells, and anti‐ferroptosis ...
Weihong Du, Yuxian He, Liangchen Li, Xinchun Jin, Panpan Geng   +4 more
wiley   +1 more source

Insights Into Effects of Natural Bioactive Components on Inflammatory Diseases in Respiratory Tract

Phytotherapy Research, EarlyView.
ABSTRACT The increasing prevalence of inflammatory diseases in the respiratory tract worldwide has raised concerns, and due to its high prevalence and poor prognosis, it remains a clinical focus and research hotspot. These inflammatory diseases include airway inflammation, asthma, bacterial antigens‐induced tonsil epithelial inflammation, chronic ...
Jincan Luo, Jinhai Luo, Zhonghao Fang, Yu Fu, Baojun (Bruce) Xu   +4 more
wiley   +1 more source

Harmonizing NAD+ metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment

VIEW, EarlyView.
Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang, Ming Chen, Yi Tian, Bo Qin, Xiaoxiao Chen, Yiwen Zhou, Jinhai Huang, Mei Yang, Xinghuai Sun, Yuan Lei, Yuhong Chen   +10 more
wiley   +1 more source

Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema. [PDF]

, 2007
Emphysema is a progressive lung disease characterised by loss of lung parenchyma with associated functional changes including decreased tissue elastance. Here we report beta1 integrin is a novel target for tissue repair and regeneration in emphysema.
Chris J. Armit, David J. Harrison, Linda Wilson, Mark Marsden, Rehab J. Al-Jamal, Steven D. Shapiro, Susan McIntyre   +6 more
core   +1 more source

Retinal Caveolin-1 Modulates Neuroprotective Signaling

, 2015
Caveolin-1 (Cav-1), the scaffolding protein of caveolae, is expressed in several retinal cell types and is associated with ocular pathologies. Cav-1 modulates neuroinflammatory/neuroprotective responses to central nervous system injury. We have shown that loss of Cav-1 results in a blunted cytokine response in retinas challenged with inflammatory ...
Reagan, A., Gu, X., Hauck, S.M., Ash, J.D., Cao, G., Thompson, T.C., Elliott, M.H.   +6 more
openaire   +4 more sources

Quantifying Cytotoxicity and Cellular Uptake of Naked Gold Nanoparticles Using Total Reflection X‐Ray Fluorescence

X-Ray Spectrometry, EarlyView.
ABSTRACT The study of the cytotoxic effects of gold nanoparticles (AuNP) is an active area of research. However, there is a lack of consistency in results with measures of cellular uptake relying on inductively coupled plasma (ICP)‐based methods, which introduce inconsistencies with sample preparation.
Natasha Hedden, Gabriela Traplin, Gabriella Mankovskii, Raffi Karshafian, Michael Kolios, Ana Pejovic‐Milic   +5 more
wiley   +1 more source