Results 101 to 110 of about 60,250 (276)

Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes [PDF]

, 2013
Caveolae are a specialized type of lipid rafts that are stabilized by oligomers of caveolin protein. Caveolae are particularly enriched in adipocytes. Here we analyzed the effects of caveolin-1 knockdown and caveolae ablation on adipocyte function.
Calvo, María, Camps, Marta, González-Muñoz, Elena, López-Iglesias, Carmen, Palacín, Manuel, Zorzano, Antonio   +5 more
core   +2 more sources

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Caveolin-1 interacts with the chaperone complex TCP-1 and modulates its protein folding activity [PDF]

, 2018
.: We report that caveolin-1, one of the major structural protein of caveolae, interacts with TCP-1, a hetero-oligomeric chaperone complex present in all eukaryotic cells that contributes mainly to the folding of actin and tubulin.
Bender, F., Bron, C., Doucey, M., Hess, D., Hofsteenge, J.   +4 more
core  

The Caveolin-1 Connection to Cell Death and Survival [PDF]

, 2013
Nunez, S (Nunez, S.)[ 1,4 ] 1. Fac Med, CEMC, Lab Comunicac Celulares, Santiago, Chile. 4. Univ Talca, Fac Hlth Sci, Talca, ChileCaveolins are a family of membrane proteins required for the formation of small plasma membrane invaginations called caveolae
Aguirre, A., Fernandez, J.G., Leyton, L., Lobos-Gonzalez, L., Nunez, S., Quest, A.F.G.G., Rodriguez, D., Sanhueza, C., Torres, V.   +8 more
core   +1 more source

Nitroglycerin Tolerance in Caveolin-1 Deficient Mice

PLoS ONE, 2014
Nitrate tolerance developed after persistent nitroglycerin (GTN) exposure limits its clinical utility. Previously, we have shown that the vasodilatory action of GTN is dependent on endothelial nitric oxide synthase (eNOS/NOS3) activity. Caveolin-1 (Cav-1) is known to interact with NOS3 on the cytoplasmic side of cholesterol-enriched plasma membrane ...
Mao Mao, Sudhahar Varadarajan, Tohru Fukai, Farnaz R Bakhshi, Olga Chernaya, Samuel C Dudley, Richard D Minshall, Marcelo G Bonini   +7 more
openaire   +4 more sources

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion [PDF]

, 2003
EGF receptor (EGFR) overexpression correlates with metastasis in a variety of carcinomas, but the underlying mechanisms are poorly understood. We demonstrated that EGF disrupted cell-cell adhesion and caused epithelial-to-mesenchymal transition (EMT) in ...
Lu, Zhimin, Ghosh, Sourav, Wang, Zhiyong, Hunter, Tony   +3 more
core   +1 more source

Small and large intestine express a truncated Dab1 isoform that assembles in cell-cell junctions and co-localizes with proteins involved in endocytosis [PDF]

, 2018
Disabled-1 (Dab1) is an essential intracellular adaptor protein in the reelin pathway. Our previous studies in mice intestine showed that Dab1 transmits the reelin signal to cytosolic signalling pathways.
Balda, María S., García Miranda, Pablo, Ilundáin Larrañeta, María Anunciación Ana, Matter, Karl, Peral Rubio, María José, Vázquez Carretero, María Dolores   +5 more
core   +1 more source

Projected Warming of the Southern Ocean Disrupts Embryonic Development and Hatch Timing in Antarctic Fish

Global Change Biology Communications, EarlyView.
Embryos are particularly sensitive to thermal challenge. Antarctic fish embryos raised at projected Southern Ocean temperatures hatch during the winter, have a high incidence of morphological abnormalities, have shorter body lengths, and express genes indicative of cellular stress.
Margaret Streeter, Nathalie R. Le François, Thomas Desvignes, Jacob Grondin, John H. Postlethwait, H. William Detrich III, Jacob M. Daane   +6 more
wiley   +1 more source

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality? [PDF]

, 2016
Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and multiple internal organs and severe functional and structural microvascular alterations.
Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +1 more
core   +2 more sources

Screening anticancer peptides performance in organotypic prostate tumor‐stroma 3D models

International Journal of Cancer, EarlyView.
What's New? Peptide‐based drugs have emerged as promising anticancer therapies for their potential to disrupt protein–protein interactions. In this study, the authors developed a physiomimetic human 3D prostate cancer spheroid model to assess the efficacy of the CAVPENET peptide in inhibiting tumor growth. Upon incubation with CAVPENET, prostate cancer
Bárbara Matos, Maria V. Monteiro, Matilde R. Lagarto, John Howl, Carmen Jerónimo, Vítor M. Gaspar, João F. Mano, Margarida Fardilha   +7 more
wiley   +1 more source