Results 11 to 20 of about 60,250 (276)
Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. [PDF]
PLoS ONE, 2014 Caveolin-1 is a scaffolding/regulatory protein that interacts with diverse signaling molecules. Caveolin-1(null) mice have marked metabolic abnormalities, yet the underlying molecular mechanisms are incompletely understood.
Takashi Shiroto +7 more
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Caveolin-2 associates with intracellular chlamydial inclusions independently of caveolin-1 [PDF]
BMC Infectious Diseases, 2004 Background Lipid raft domains form in plasma membranes of eukaryotic cells by the tight packing of glycosphingolipids and cholesterol. Caveolae are invaginated structures that form in lipid raft domains when the protein caveolin-1 is expressed.
Norkin Leonard C +2 more
doaj +5 more sources
Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis. [PDF]
PLoS ONE, 2012 Caveolin-1, the structural protein component of caveolae, acts as a scaffolding protein that functionally regulates signaling molecules. We show that knockdown of caveolin-1 protein expression enhances chemotherapeutic drug-induced apoptosis and inhibits
Huafei Zou +2 more
doaj +8 more sources
Revolutionizing Autoimmune Research: The Role of Caveolin‐1 [PDF]
Immunity, Inflammation and DiseaseIntroduction Caveolins (Cav) include Cav‐1, Cav‐2, and Cav‐3, with Cav‐1 being the most studied due to its prominent role as a major component of plasma membrane caveolae.
Yanan Gao +8 more
doaj +2 more sources
SNX19 Interacts with Caveolin-1 and Flotillin-1 to Regulate D1R Endocytosis and Signaling [PDF]
BiomedicinesBackground: Sorting nexin 19 (SNX19) is important in the localization and trafficking of the dopamine D1 receptor (D1R) to lipid raft microdomains. However, the interaction between SNX19 and the lipid raft components caveolin-1 or flotillin-1 and, in ...
Bibhas Amatya +13 more
doaj +2 more sources
Fertility & Reproduction, 2023 Background and Aims: Endometrial decidualization is a step in establishing and maintaining pregnancy. Senescence was considered to accompany with decidualization.
Song Zhuo
doaj +1 more source
Impaired Phagocytosis in Caveolin-1 Deficient Macrophages [PDF]
Cell Cycle, 2005 Caveolae are plasma membrane invaginations that function as important regulators of numerous cellular processes, including signal transduction, cholesterol trafficking, and endocytosis. Caveolin-1 (Cav-1) constitutes the main structural protein of caveolae membranes. Here, we report an in vivo increase in the number of apoptotic cells in the thymus and
Jiangwei Li +7 more
openalex +3 more sources
Caveolin-1-enhanced motility and focal adhesion turnover require tyrosine-14 but not accumulation to the rear in metastatic cancer cells. [PDF]
PLoS ONE, 2012 Caveolin-1 is known to promote cell migration, and increased caveolin-1 expression is associated with tumor progression and metastasis. In fibroblasts, caveolin-1 polarization and phosphorylation of tyrosine-14 are essential to promote migration. However,
Hery Urra +8 more
doaj +1 more source
Lipid organization by the Caveolin-1 complex. [PDF]
Biophys JAbstractCaveolins are lipid-binding proteins that can organize membrane remodeling and oligomerize into the 8S-complex. The CAV1 8S-complex comprises a disk-like structure, about 15nm in diameter, with a central beta barrel. Further oligomerization of 8S-complexes remodels the membrane into caveolae vessels, with a dependence on cholesterol ...
Liebl K, Voth GA.
europepmc +4 more sources
Caveolin-1, caveolae, and glioblastoma [PDF]
Neuro-Oncology, 2012 Glioblastoma multiforme (GBM) is the most common malignant brain tumor and is characterized by high invasiveness, poor prognosis, and limited therapeutic options. Biochemical and morphological experiments have shown the presence of caveolae in glioblastoma cells. Caveolae are flask-shaped plasma membrane subdomains that play trafficking, mechanosensing,
Parat, Marie-Odile, Riggins, Gregory J.
openaire +3 more sources