Caveolin-1 in renal disease [PDF]
Scientific Journal of Genetics and Gene Therapy, 2018 Caveolin-1 is the essential structural formation for lipid raft formation. It has been ascribed to several disease processes in humans due to its ubiquitous distribution.
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Caveolin-1 is an aggresome-inducing protein [PDF]
Scientific Reports, 2016 AbstractCaveolin-1 (Cav1) drives the formation of flask-shaped membrane invaginations known as caveolae that participate in signaling, clathrin-independent endocytosis and mechanotransduction. Overexpression or mutations of Cav1 can lead to its mistrafficking, including its accumulation in a perinuclear compartment previously identified as the Golgi ...
Krishnan Raghunathan +5 more
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A New N-terminal Recognition Domain in Caveolin-1 Interacts with Sterol Carrier Protein-2 (SCP-2) [PDF]
, 2007 Although plasma membrane domains, such as caveolae, provide an organizing principle for signaling pathways and cholesterol homeostasis in the cell, relatively little is known regarding specific mechanisms, whereby intracellular lipid-binding proteins are
Ball, Judith M. +7 more
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Caveolin-2 associates with intracellular chlamydial inclusions independently of caveolin-1 [PDF]
, 2004 Background Lipid raft domains form in plasma membranes of eukaryotic cells by the tight packing of glycosphingolipids and cholesterol. Caveolae are invaginated structures that form in lipid raft domains when the protein caveolin-1 is expressed.
Elizabeth S Stuart +2 more
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Role of caveolin-1 in fibrotic diseases
Matrix Biology, 2013 Fibrosis underlies the pathogenesis of numerous diseases and leads to severe damage of vital body organs and, frequently, to death. Better understanding of the mechanisms resulting in fibrosis is essential for developing appropriate treatment solutions and is therefore of upmost importance.
Gvariama, D. +3 more
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Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. [PDF]
, 2019 Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in this
Dobrow, Sebastian +7 more
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The Rotavirus Enterotoxin NSP4 Directly Interacts with the Caveolar Structural Protein Caveolin-1 [PDF]
, 2006 Rotavirus nonstructural protein 4 (NSP4) is known to function as an intracellular receptor at the endoplasmic reticulum (ER) critical to viral morphogenesis and is the first characterized viral enterotoxin.
Ball, Judith M. +6 more
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Caveolin-1 in Melanoma Progression [PDF]
, 2011 Cancer is a leading cause of death world wide and mortality due to this group of diseases has doubled in the last 20 years. With an estimated 3 million cases, skin cancer is currently the third most common human malignancy and global incidence is rising at an alarming rate due to environmental changes.
Gonzalo Fernández +4 more
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Plasma from Volunteers Breathing Helium Reduces Hypoxia-Induced Cell Damage in Human Endothelial Cells-Mechanisms of Remote Protection Against Hypoxia by Helium. [PDF]
, 2019 PurposeRemote ischemic preconditioning protects peripheral organs against prolonged ischemia/reperfusion injury via circulating protective factors. Preconditioning with helium protected healthy volunteers against postischemic endothelial dysfunction.
Augustijn, Quinten JJ +7 more
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Glycosphingolipid Mediated Caveolin-1 Oligomerization [PDF]
Journal of Glycomics & Lipidomics, 2012 We have previously demonstrated an association between the accumulation of the glycosphingolipid globotriaosylceramide (Gb3) and the loss of high molecular weight oligomers in the aortas of α-galactosidase A-knockout mice, a model of Fabry disease. In the present study the molecular basis for the association between glycosphingolipids and caveolin-1 ...
Liming Shu, James A. Shayman
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