Glycosphingolipid Mediated Caveolin-1 Oligomerization [PDF]
Journal of Glycomics & Lipidomics, 2012 We have previously demonstrated an association between the accumulation of the glycosphingolipid globotriaosylceramide (Gb3) and the loss of high molecular weight oligomers in the aortas of α-galactosidase A-knockout mice, a model of Fabry disease. In the present study the molecular basis for the association between glycosphingolipids and caveolin-1 ...
Liming, Shu, James A, Shayman
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Author Correction: A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population. [PDF]
Sci RepYaikwawong M +8 more
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Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice [PDF]
International Neurourology Journal, 2015 Purpose: It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify
Seheon Jung +6 more
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Caveolin‐1, cancer and therapy resistance [PDF]
International Journal of Cancer, 2018 Resistance of solid tumors to chemo‐ and radiotherapy remains a major obstacle in anti‐cancer treatment. Herein, the membrane protein caveolin‐1 (CAV1) came into focus as it is highly expressed in many tumors and high CAV1 levels were correlated with tumor progression, invasion and metastasis, and thus a worse clinical outcome.
Julia Ketteler, Diana Klein
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Caveolin-1 Signaling in Lung Fibrosis [PDF]
The Open Rheumatology Journal, 2012 Caveolin-1 is a master regulator of several signaling cascades because it is able to bind to and thereby inhibit members of a variety of kinase families. While associated with caveolae and involved in their generation, caveolin-1 is also present at other sites.
Tourkina, Elena, Hoffman, Stanley
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Caveolin-1 Dependent Endocytosis Enhances the Chemosensitivity of HER-2 Positive Breast Cancer Cells to Trastuzumab Emtansine (T-DM1). [PDF]
PLoS ONE, 2015 The humanized monoclonal antibody-drug conjugate trastuzumab emtansine (T-DM1, Kadcyla) has been approved by the U.S. FDA to treat human epidermal growth factor receptor 2 (HER-2)-positive metastatic breast cancer.
Yuan-Chiang Chung +4 more
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Acta Pharmaceutica Sinica B, 2021 As one of the most important components of caveolae, caveolin-1 is involved in caveolae-mediated endocytosis and transcytosis pathways, and also plays a role in regulating the cell membrane cholesterol homeostasis and mediating signal transduction.
Canyu Yang +6 more
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Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. [PDF]
, 2008 OBJECTIVE: Recent studies have implicated caveolin 1 in the regulation of transforming growth factor beta (TGFbeta) downstream signaling. Given the crucial role of TGFbeta in the pathogenesis of systemic sclerosis (SSc), we sought to determine whether ...
de Almeida, Cecilia J. +6 more
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Lifestyle intervention in individuals with impaired glucose regulation affects Caveolin-1 expression and DNA methylation [PDF]
, 2020 © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Aims: We investigated whether a lifestyle intervention could influence expression and DNA methylation of diabetes-related genes in patients with impaired ...
Adam, S. +9 more
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Caveolin-1 expression is elevated in claudin-low mammary tumor cells
Cancer Cell International, 2012 Background Caveolin-1 is a scaffolding protein found in plasma membrane invaginations known as caveolae. Caveolin-1 can regulate a number of intracellular processes such as signal transduction, cholesterol metabolism and vesicular transport. With respect
Thompson Devan E +2 more
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