Results 11 to 20 of about 81,610 (330)
Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond [PDF]
Frontiers in Immunology, 2017 Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1 ...
Cecília Jacques Gonçalves de Almeida
doaj +5 more sources
Caveolin-1 Dependent Endocytosis Enhances the Chemosensitivity of HER-2 Positive Breast Cancer Cells to Trastuzumab Emtansine (T-DM1). [PDF]
PLoS ONE, 2015 The humanized monoclonal antibody-drug conjugate trastuzumab emtansine (T-DM1, Kadcyla) has been approved by the U.S. FDA to treat human epidermal growth factor receptor 2 (HER-2)-positive metastatic breast cancer.
Yuan-Chiang Chung +4 more
doaj +2 more sources
Caveolins in rhabdomyosarcoma [PDF]
Journal of Cellular and Molecular Medicine, 2011 Caveolins are scaffolding proteins that play a pivotal role in numerous processes, including caveolae biogenesis, vesicular transport, cholesterol homeostasis and regulation of signal transduction. There are three different isoforms (Cav-1, -2 and -3) that form homo- and hetero-aggregates at the plasma membrane and modulate the activity of a number of ...
Alessandro Fanzani +4 more
openaire +6 more sources
Molecular architecture of the human caveolin-1 complex
bioRxiv, 2022 Membrane sculpting proteins shape the morphology of cell membranes and facilitate remodeling in response to physiological and environmental cues. Complexes of the monotopic membrane protein caveolin function as essential curvature-generating components ...
J. Porta +10 more
semanticscholar +1 more source
Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae
Journal of Cell Biology, 2021 We integrated quantitative nanoscale lipid mapping with molecular dynamic simulations to define the lipid profile within caveolae. Caveolin-1 and cavin1 individually sort distinct plasma membrane lipids.
Yong Zhou +11 more
semanticscholar +1 more source
Caveolin Revealed: A Mutagenesis Study of Caveolin-1 [PDF]
Biophysical Journal, 2015 Caveolae are 50-100 nm invaginations in the plasma membrane that are rich in cholesterol, sphingomyelin and the integral membrane protein called caveolin-1. Caveolin-1 has three main functions: forming caveolae, cell signaling, and endocytosis. To examine the importance of conserved residues within the scaffolding and intra-membrane domains of caveolin-
Sarah M. Plucinsky +1 more
openaire +2 more sources
Identification of Caveolin and Caveolin-Related Proteins in the Brain [PDF]
The Journal of Neuroscience, 1997 Caveolae are 50–100 nm, nonclathrin-coated, flask-shaped plasma membrane microdomains that have been identified in most mammalian cell types, except lymphocytes and neurons. To date, multiple functions have been ascribed to caveolae, including the compartmentalization of lipid and protein components that function in transmembrane signaling events ...
Johnna W. Ruffin +4 more
openaire +2 more sources
Expression of Caveolin-1, Caveolin-2 and Caveolin-3 in Thyroid Cancer and Stroma [PDF]
Pathobiology, 2012 <i>Objective:</i> To study the expression status of caveolin-1, caveolin-2 and caveolin-3 in the epithelial and stromal compartments of conventional papillary thyroid carcinoma (PTC), diffuse sclerosing variant of papillary carcinoma (DSVPC) and anaplastic carcinoma (AC).
Dokyung Kim, Haeryoung Kim, Ja Seung Koo
openaire +3 more sources
M‐caveolin, a muscle‐specific caveolin‐related protein [PDF]
FEBS Letters, 1995 Caveolae, small invaginations of the plasma membrane, are a characteristic feature of many mammalian cells. The best‐characterised caveolar protein is the integral membrane protein, VIP21‐caveolin. We now describe a novel homologue of VIP21‐caveolin, M‐caveolin, which is expressed exclusively in muscle.
Way, Michael, Parton, Robert G.
openaire +5 more sources
Cell Death and Disease, 2020 Aflatoxin B1 (AFB1) is a potent hepatocarcinogen in humans and exposure to AFB1 is known to cause both acute and chronic hepatocellular injury. As the liver is known to be the main target organ of aflatoxin, it is important to identify the key molecules ...
Qingqiang Xu +12 more
semanticscholar +1 more source