Results 41 to 50 of about 81,610 (330)

Caveolin-1 expression is elevated in claudin-low mammary tumor cells

Cancer Cell International, 2012
Background Caveolin-1 is a scaffolding protein found in plasma membrane invaginations known as caveolae. Caveolin-1 can regulate a number of intracellular processes such as signal transduction, cholesterol metabolism and vesicular transport. With respect
Thompson Devan E, Siwicky Megan D, Moorehead Roger A   +2 more
doaj   +1 more source

Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis. [PDF]

, 2010
The most severe clinical and pathologic manifestations of systemic sclerosis (SSc) are the result of a fibrotic process characterized by the excessive and often progressive deposition of collagen and other connective tissue macromolecules in skin and ...
Castro, Susan V., Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +2 more
core   +2 more sources

Caveolin-1 in the regulation of cell metabolism: a cancer perspective

Molecular Cancer, 2016
Caveolin-1 (CAV1) is an oncogenic membrane protein associated with endocytosis, extracellular matrix organisation, cholesterol distribution, cell migration and signaling.
Z. Nwosu, M. Ebert, S. Dooley, C. Meyer
semanticscholar   +1 more source

Caveolin in breast cancer [PDF]

Cancer Biology & Therapy, 2004
Caveolin-1 is the principal structural protein of caveolae, sphingolipid and cholesterol-rich invaginations of the plasma membrane involved in vesicular trafficking and signal transduction. During caveolae-dependent signaling, caveolin-1 acts as a scaffold protein to sequester and organize multi-molecular signaling complexes involved in diverse ...
Toula Bouras, Michael P. Lisanti, Richard G. Pestell   +2 more
openaire   +3 more sources

C-Terminal Region of Caveolin-3 Contains a Stretch of Amino Acid Residues Capable of Diminishing Symptoms of Experimental Autoimmune Encephalomyelitis but Not Rheumatoid Arthritis Modeled in Rats

Biomedicines, 2023
A short synthetic peptide from the C-terminal part of the caveolin-3 structure was tested for experimental autoimmune encephalomyelitis (EAE) treatment in rats.
Alexey V. Danilkovich, Valery I. Turobov, Victor A. Palikov, Yulia A. Palikova, Anna O. Shepelyakovskaya, Evgeniy S. Mikhaylov, Gulsara A. Slashcheva, Tatiana E. Shadrina, Elvira R. Shaykhutdinova, Ekaterina A. Rasskazova, Elena A. Tukhovskaya, Oksana N. Khokhlova, Igor A. Dyachenko, Alina M. Ismailova, Dmitry V. Zinchenko, Elena V. Navolotskaya, Valery M. Lipkin, Arkady N. Murashev, Igor. P. Udovichenko   +18 more
doaj   +1 more source

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells [PDF]

, 2018
Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus.
A Milewska, A Pratelli, A Quan, Aleksandra Milewska, AM Zaki, Artur Szczepanski, B Hernaez, B Jancekova, BA Mainou, BJ Dille, C Burkard, C Kooi, C Liu, C Liu, D Dutta, DM Blau, E Dietzel, E Girard, E Hamme Van, EJ Bowman, F Samson, G Preta, GA Wudiri, GM Li, GR Ares, H Imhoff, H Lin, H Wang, IC Huang, IM Mackay, J Li, J Schindelin, J Somsel Rodman, JA Mitchell, JK Millet, JL Wang, JP Lim, JR Henley, Judy A. Mitchell, K Erles, K Erles, K Owczarek, K Shirato, K Shirato, Katarzyna Owczarek, Krzysztof Pyrc, KS Choi, L Kleist von, L Pelkmans, LH Wang, LJ Reed, M Marsh, MG Hemida, MJ Geisow, MJ Vincent, O Achour, O Heikkila, P Duckert, P Eifart, P Oh, Q Xu, R Nomura, S Bertram, S Bolte, S Gierer, S Matsuyama, SL Priestnall, TA Hill, VC Chu, X Ren, Y Inoue, Y Phonphok, Z Qian, Z Qinfen, Zbigniew Baster, Zenon Rajfur   +75 more
core   +6 more sources

Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells

Nature Communications, 2016
Hypoxia promotes tumour aggressiveness and resistance of cancers to oncological treatment. The identification of cancer cell internalizing antigens for drug targeting to the hypoxic tumour niche remains a challenge of high clinical relevance.
E. Bourseau-Guilmain, J. Menard, Eva Lindqvist, V. I. Chandran, H. Christianson, M. C. Magaña, Jon Lidfeldt, Gyorgy Marko-Varga, Gyorgy Marko-Varga, C. Welinder, Mattias Belting   +10 more
semanticscholar   +1 more source

Expression of Caveolin-1 Is Required for the Transport of Caveolin-2 to the Plasma Membrane [PDF]

Journal of Biological Chemistry, 1999
Caveolins-1 and -2 are normally co-expressed, and they form a hetero-oligomeric complex in many cell types. These caveolin hetero-oligomers are thought to represent the assembly units that drive caveolae formation in vivo. However, the functional significance of the interaction between caveolins-1 and -2 remains unknown.
Cesare Peschle, Cesare Peschle, Ferruccio Galbiati, Tsuneya Ikezu, Jeffrey A. Engelman, Isabella Parolini, Isabella Parolini, Philipp E. Scherer, Francesco Grignani, Michael P. Lisanti, Massimo Sargiacomo, Rosalia Mora, Giovanni Rizzo, Enrique Rodriguez-Boulan, Takashi Okamoto   +14 more
openaire   +4 more sources

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Caveolae/Caveolin-1 Are Important Modulators of Store-Operated Calcium Entry in Hs578/T Breast Cancer Cells

Journal of Pharmacological Sciences, 2008
Caveolin-1 is a principal component of caveolae, invaginations of the plasma membrane that are enriched in cholesterol and sphingolipids. The expression of caveolin-1 has been shown to be tightly correlated to the progression of breast cancer tumors ...
Hua Zhu, Noah Weisleder, Ping Wu, Chuanxi Cai, Jian-wen Chen   +4 more
doaj   +1 more source