Results 51 to 60 of about 81,610 (330)
Microorganisms, 2022 Mutualistic bacteria have different forms of interaction with the host. In contrast to the invasion of pathogenic bacteria, naturally occurring internalization of commensal bacteria has not been studied in depth.
Diana Aurora Ramirez-Sánchez +5 more
doaj +1 more source
OncoTarget, 2017 Hyperphosphorylation of Tau forming neurofibrillary tangles has been considered as a crucial event in the pathogenesis of Alzheimer's disease (AD). MiR-124-3p belongs to microRNA (miRNA) family and was markedly decreased in AD, however, the functions of ...
Qingmei Kang +11 more
semanticscholar +1 more source
Getting rid of caveolins: Phenotypes of caveolin-deficient animals
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005 The elucidation of the role of caveolae has been the topic of many investigations which were greatly enhanced after the discovery of caveolin, the protein marker of these flask-shaped plasma membrane invaginations. The generation of mice deficient in the various caveolin genes (cav-1, cav-2 and cav-3) has provided physiological models to unravel the ...
Soazig Le Lay, Teymuras V. Kurzchalia
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Sphingolipids and membrane environments for caveolin [PDF]
FEBS Letters, 2009 Caveolin‐1, and probably also ‐2 and ‐3, can organize multimolecular membrane complexes involved in transmembrane traffic, cell adhesion and signal transduction. In this review, we discuss on the importance of caveolin membrane environment in regulating the architecture and function of such complexes, with a special emphasis on the role of ...
A.E.G. Prinetti, S. Sonnino
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Metformin-induced caveolin-1 expression promotes T-DM1 drug efficacy in breast cancer cells
Scientific Reports, 2018 Trastuzumab emtansine (T-DM1) is an antibody drug conjugate (ADC) that was recently approved for the treatment of HER-2-positive metastatic breast cancer. The drug sensitivity of ADCs depends mainly on the internalization efficiency of the drug. Caveolin-
Yuan‐Chiang Chung +5 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2023 Introduction: Extensive studies indicated that caveolin is a key regulator in multiple cellular processes. Recently, growing evidence demonstrated that caveolin is critically involved in tumor progression.
Yaqian Tan, Qi Song
doaj +1 more source
Oncogene, 2017 N-myc downstream-regulated gene 1 (NDRG1) has been reported to act as a key regulatory molecule in tumor progression-related signaling pathways, especially in tumor metastasis. However, the related mechanism has not been fully discovered yet.
L. Mi +11 more
semanticscholar +1 more source
Caveolins in cardioprotection – translatability and mechanisms [PDF]
British Journal of Pharmacology, 2015 Translation of preclinical treatments for ischaemia‐reperfusion injury into clinical therapies has been limited by a number of factors. This review will focus on a single mode of cardiac protection related to a membrane scaffolding protein, caveolin, which regulates protective signalling as well as myocyte ultrastructure in the setting of ischaemic ...
Hemal H. Patel +5 more
openaire +5 more sources
Caveolin-1 expression in benign and malignant lesions of the breast
World Journal of Surgical Oncology, 2007 Background Caveolin-1 is thought to have an important impact on both signal transduction and mediation of intracellular processes. Furthermore, it has been suggested that Caveolin-1 may contribute to certain steps of carcinogenesis in various types of ...
Kiesel Ludwig +4 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2017 Edwardsiella tarda is a Gram-negative bacterium that can infect a broad range of hosts including humans and fish. Accumulating evidences have indicated that E. tarda is able to survive and replicate in host phagocytes.
Zhi-Hai Sui +5 more
semanticscholar +1 more source