Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. [PDF]
, 2018 Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4+ T cells.
Borlido, Joana +6 more
core +1 more source
Caveolin-1 gene expression in rats model of chronic renal failure
Medicine Science, 2017 In this study, gene expression profile of caveoline and the kidney MDA levels and serum BUN and creatinine levels were investigated in experimentally induced renal failure case of rats.
Berna Ozyazgan +2 more
doaj +1 more source
Oral Protein Therapy for the Future - Transport of Glycolipid-Modified Proteins: Vision or Fiction? [PDF]
, 2010 The reliable and early diagnosis of common complex multifactorial diseases depends on the individual determination of all (or as many as possible) polymorphisms of each susceptibility gene together with amount and type of the corresponding gene products ...
Mueller, Guenter
core +1 more source
Review: Dystroglycan in the Nervous System [PDF]
, 2007 Dystroglycan is part of a large complex of proteins, the dystrophin-glycoprotein complex, which has been implicated in the pathogenesis of muscular dystrophies for a long time.
Matthias Samwald
core +2 more sources
Caveolin-3 in muscular dystrophy [PDF]
Human Molecular Genetics, 1998 The dystrophin-glycoprotein complex (DGC) serves as a link between cytoplasmic actin, the membrane and the extracellular matrix of striated muscle. Genetic defects in genes encoding a subset of DGC proteins result in muscular dystrophy and a secondary decrease in other DGC proteins.
E M, McNally +10 more
openaire +2 more sources
Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface
Microorganisms, 2019 Human adenovirus infection of the ocular surface is associated with severe keratoconjunctivitis and the formation of subepithelial corneal infiltrates, which may persist and impair vision for months to years following infection.
Matthew R. Pennington +7 more
doaj +1 more source
Caveolae and Lipid Rafts in Endothelium: Valuable Organelles for Multiple Functions
Biomolecules, 2020 Caveolae are flask-shaped invaginations of the plasma membrane found in numerous cell types and are particularly abundant in endothelial cells and adipocytes.
Antonio Filippini, Alessio D’Alessio
doaj +1 more source
ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth [PDF]
, 2017 Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death; identifying PDAC enablers may reveal potential therapeutic targets. Expression of the actomyosin regulatory ROCK1 and ROCK2 kinases increased with tumor progression in human and ...
Anderson, Kurt I. +12 more
core +1 more source
The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model. [PDF]
, 2019 The increase in atmospheric oxygen levels imposed significant environmental pressure on primitive organisms concerning intracellular oxygen concentration management.
Patel, Hemal H, Zuniga-Hertz, Juan Pablo
core +1 more source
Transient receptor potential melastatin 7 cation channel kinase new player in angiotensin II–induced hypertension [PDF]
, 2016 Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein comprising a magnesium (Mg2+)/cation channel and a kinase domain. We previously demonstrated that vasoactive agents regulate vascular TRPM7.
Antunes, Tayze T. +9 more
core +1 more source