Unraveling the Cave: A Seventy-Year Journey into the Caveolar Network, Cellular Signaling, and Human Disease [PDF]
Cells, 2023 In the mid-1950s, a groundbreaking discovery revealed the fascinating presence of caveolae, referred to as flask-shaped invaginations of the plasma membrane, sparking renewed excitement in the field of cell biology.
Alessio D’Alessio
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Potential of caveolae in the therapy of cardiovascular and neurological diseases [PDF]
Frontiers in Physiology, 2014 Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated ...
Gemma eNavarro +3 more
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Caveolin and oxidative stress in cardiac pathology [PDF]
Frontiers in PhysiologyCaveolins interact with signaling molecules within caveolae and subcellular membranes. Dysregulation of caveolin function and protein abundance contributes to cardiac pathophysiological processes, driving the development and progression of heart disease.
Lauren Zadorozny +9 more
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The importance of caveolin as a target in the prevention and treatment of diabetic cardiomyopathy [PDF]
Frontiers in Immunology, 2022 The diabetic population has been increasing in the past decades and diabetic cardiomyopathy (DCM), a pathology that is defined by the presence of cardiac remodeling and dysfunction without conventional cardiac risk factors such as hypertension and ...
Weiyi Xia +7 more
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Pathophysiological Role of Caveolae in Hypertension [PDF]
Frontiers in Medicine, 2019 Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1–4, EHD2, pacsin2, and dynamin 2.
Xiaoming Lian +5 more
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Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity [PDF]
Journal of Lipid Research, 2011 Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-null ...
Tova Meshulam +4 more
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Caveolins and macrophage lipid metabolism
Journal of Lipid Research, 2003 The identification of caveolin-1 more than a decade ago initiated active research into its role in the formation of caveolae, membrane trafficking, signal transduction pathways, and lipid homeostasis.
Ladislav Dory
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A model for membrane curvature generation by caveolin discs driven by differential contact interaction [PDF]
Nature CommunicationsThe recent discovery of the flat, disc-like structure of caveolin oligomers, predicted to be embedded in one membrane leaflet, has challenged earlier models of membrane curvature generation by caveolins during caveola biogenesis.
Avishai Barnoy +3 more
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Silver Nanoparticles (AgNPs) Uptake by Caveolae-Dependent Endocytosis is Responsible for Their Selective Effect Towards Castration Resistant Prostate Cancer [PDF]
International Journal of NanomedicineMariana Morais,1,2 Francisca Dias,1 Patrícia Figueiredo,3 Inês Tavares,1,2 Carla Escudeiro,4,5 Manuel R Teixeira,2,4,5 Alexandra Teixeira,6 Johnny Lisboa,6 Kirsi S Mikkonen,3,7 Ana L Teixeira,1 Rui Medeiros1,2,8– 10 1Molecular Oncology and Viral ...
Morais M +10 more
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Therapeutic role of caveolin family in stem cell fate and development for management of chronic degenerative diseases: A scientometric study to an in-depth review [PDF]
Journal of Advanced ResearchBackground: Caveolins (CAV), a family of integral membrane proteins, are involved in regulating stem cell fate, which are critical for tissue repair and regeneration. Drawing from scientometric studies and comprehensive research, this review investigates
Ruishuang Ma +6 more
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